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Tadalafil is very specific for PDE5 and is also very specific for the enzyme PDE11. Unfortunately, we don’t know much about PDE11, which is found in the heart, in the pituitary gland in the brain and in the testicles. Pharmacokinetics, half-life, is how long the medication stay s in the blood. Sildenafil (Viagra) has a half-life of 4 hours and vardenafil (Levitra) has a half-life of 4-6 hours while tadalafil (Cialis) has a half-life of 17.5 hours. This means that vardenafil (Levitra) should act longer than sildenafil (Viagra) but the clinical significance is not known. Tadalafil (Cialis) has the longest half-life and allows you to take the medication and not relate the sexual activity to the immediate use of the medication. The drawback is if you need nitrates after using tadalafil (Cialis), this medication lasts a long time in your blood stream and may place you at a higher risk. Younger people might do well treated with tadalafil, (Cialis) while older people with other health issues might be better off using sildenafil (Viagra) or vardenafil (Levitra) but more data are needed. The side effects of vardenafil (Levitra) are potentially less than sildenafil (Viagra), but more data are needed. In a recent study on men with erectile dysfunction and diabetes, vardenafil (Levitra) improved their erectile dysfunction. Tadalafil (Cialis) is as effective as sildenafil (Viagra), and vardenafil (Levitra) with similar side effects except for back pain that occurs occasionally with tadalafil, probably because of the long half-life. Many people stop taking drugs because they are experiencing side effects, they no longer have a partner, or they are worried about safety. Sexual activity is not a major contributor to the risk of a heart attack. Sexual activity, with or without sildenafil (Viagra) increases the chance of an MI during sexual activity by only 0.1%. If pills fail, there are vacuum devices, Muse, injections, bypass surgery and implants. The patient making a presentation has had penile bypass surgery. In addition he takes testosterone and sildenafil as needed.. This is a classic example of why people with ED need complete care: a psychological exam, history and physical exam, and diagnostic studies with long term follow-up care. Patients with ED should not just be prescribed sildenafil (Viagra) and then be lost to follow-up. These medications have the same active ingredient and the same effect, medically. The difference between them is in the branding and availability. Generic medications like Sildenafil are cheaper, but just as effective as branded ones like Viagra. It can be easier and cheaper to get Sildenafil, either online or through the NHS. Please check your spelling or try another treatment name. Viagra and sildenafil have different names, so you’d be forgiven for thinking that they were two completely different drugs. In fact, Viagra and sildenafil are identical in all of the following ways : Their active ingredients (sildenafil citrate) Dosages (drug strength) Efficacy (how well they work) How long they take to start working How long they work for Safety and side effects The size of the packs they come in Restrictions based on your current health status or other medications you're taking. – it’s really common for medicines to have more than one name. These are – their generic name (usually the name of the active ingredient of the drug), and one or more different brand names (chosen for marketing purposes). In this case, sildenafil is the generic name, and Viagra is one of the brand names, for a medication with the active ingredient sildenafil. In other words, Viagra is the brand name given to the generic medicine sildenafil. – when a new drug is discovered, the pharmaceutical company that discovers it takes out a legal patent so that other companies can’t market that same drug for a certain length of time. This means that they are the only people selling it on the market, and therefore have control over the pricing. In this case it was Pfizer owning the patent for Viagra until 2003. There are still some differences – despite containing the same active ingredients, and working in exactly the same ways, there are some differences between the two drugs. Viagra and sildenafil are different in terms of : Price (Viagra is more expensive) Manufacturer (they are made by different companies) Availability on the NHS (only certain people will be able to get an NHS prescription for Viagra, whereas sildenafil is more commonly prescribed and widely available) Medical studies under the brand name – there is also a wider range of evidence from drug trials about Viagra available. This is simply due to the fact that it has been on the market for much longer, and doesn’t mean that it is any more or less safe than sildenafil. Changes to non-medical ingredients – some branded and unbranded drugs also contain small differences in their inactive ingredients, the other ingredients in the drug used to make the medicine. This is why some medicines that work in the same way can look different, but the differences are rarely ever significant. Branded and unbranded medicines are usually interchangeable. Online availability – at Zava, both sildenafil and Viagra are available to order, as well as a wide range of other drugs used in the treatment of erectile dysfunction (ED). However, only Viagra is currently available in our erectile dysfunction trial pack of three different medications – Viagra, Levitra and Cialis. Whether brands are important to you – often, the choice between Viagra and sildenafil comes to personal preference and an instinctual feeling of safety with branded medicines. However, this is simply an effect of the marketing, as both drugs are exactly the same. How much you want to pay – price-wise, Viagra is more expensive, and is only available to a certain few on NHS prescription. Most of the time, you will have to go privately to get Viagra, whereas sildenafil is much more readily available and cheaper too. Where you are getting your treatment from – the only real difference between buying Viagra or sildenafil would come about if you are getting your prescription in-person from your GP. If you buy your ED treatment using a registered online doctor’s service, your method of purchase will be exactly the same for both drugs. What’s the difference between branded and generic medication? No medical difference – medically-speaking, branded and generic medication is the same. They both contain the same active ingredient and work in the same way. Viagra) is medication given a brand name by its manufacturer for marketing purposes. Generic medication is usually named after the active ingredient of the drug itself (e.g. Cost to you – branded medication tends to cost more than generic medication, because of the popularity of the brand name. However, both are just as safe to use, and both are regulated in exactly the same way (by the MHRA). This is why lots of people choose the cheaper option of buying generic medication over more expensive branded medication, to save money. Are there other branded/generic medications for erectile dysfunction? Tadalafil and vardenafil are the two other generic medications that are available in the UK. Tadalafil is the generic version of Cialis, and vardenafil is the generic version of Levitra. Other branded medicines include: Tadalafil and Cialis has the same relationship – Tadalafil (the generic medicine) and Cialis (the branded medicine) both contain the same active ingredient, and work in exactly the same way, just as with sildenafil and Viagra. Different active ingredients are medically different – ED treatments with different active ingredients work differently on different people, depending on the root causes of your ED, and your different personal needs. Talk to your nurse or GP if you want more information on which ED treatments could work best for you, or order our trial pack to see which suits your needs. Dr Nicholas Antonakopoulos graduated from the University of London in 2006. He did his postgraduate training in hospitals in the London area, and he trained for four years in Trauma and Orthopaedic Surgery before completing his training in General practice in 2015. Is Viagra the World's Most Popular Male Sexual Performance Drug? by Michael Castleman, December 11, 2013 | Comments: 0. In four studies where couples used Viagra, then Cialis (or vice versa), the women strongly preferred the latter. En espanol | In the pantheon of globally recognized brand names, Viagra is right up there with Coca-Cola and Rolls-Royce. In terms of user satisfaction, however, Viagra (sildenafil) runs a distant second to Cialis (tadalafil). I found 12 studies — none of them funded by the drug companies themselves — in which men from various countries tried both drugs and then reported which one they chose to continue. And the 8,300 participants favored Cialis by a wide margin — 3 to 1, on average. In studies that also included the third major erection drug, Levitra (vardenafil), Cialis was still substantially more popular than either competitor. In four studies where couples used Viagra, then Cialis (or vice versa), the women strongly preferred the latter. Blindfolds: A classic sex accessory A better sex life? Take the slow route Date night ideas for couples in a rut. Join AARP Today — Receive access to exclusive information, benefits and discounts. Viagra and Levitra are effective for approximately four hours, Cialis for 36. If a man takes Cialis on Friday evening, he can count on erection assistance through part of Sunday. Both men and women say they like the fact that Cialis allows them to take their eyes off that ticking clock and make love whenever they wish. So for dating couples or new lovers who prize sexual spontaneity, Cialis has a clear advantage. Oddly, Cialis is favored by a less sexually impulsive group as well: long-term spouses, who are likelier to schedule sex dates. The drug's more wide-open window of opportunity apparently makes for friendlier spousal negotiations over time and place. Except for their duration of action, all erection medications function in similar fashion. They work equally well if taken on an empty stomach or after a meal. None produce spontaneous erections, so no mortifying bulges in the produce aisle; they enhance firmness only in the context of erotic stimulation. Their side effects are quite similar, too: headache (16 percent of users), upset stomach (7 percent) and nasal congestion (4 percent). (Important note: Never use erection medications if you're taking nitroglycerin for angina; the combination can be fatal . Remember how close we came to losing Jack Nicholson in Something's Gotta Give? ) And you might be surprised to learn how few older men use any erection drug at all: Sales of "vitamin V" have never reached more than about half of what experts predicted when such medications were first approved in 1998. When Cornell researchers surveyed 6,291 older men on the subject, 48 percent reported some degree of erectile dysfunction, but only 7 percent had ever tried an erection drug. One reason is that, compared with women, men are less willing to take medication. But the main reason is that the drugs enhance intercourse, whereas older couples generally evolve away from the old in-out toward hand massage, oral sex and vibrator play. A "fact of life" for many older lovers is that intercourse is a hassle. Even with drugs, erections may be iffy; even with lubrication aplenty, vaginal dryness or atrophy may cause pain during intercourse. That's why many older lovers move on from intercourse to other pleasures. And if you're no longer having intercourse, erections aren't necessary, so why take a drug? In addition, men don't need erections to have orgasms. You read that right: Given sufficient fondling, a man can have a marvelous orgasm with a semifirm or even flaccid penis. Among men who try erection medications, only half refill their prescriptions. The manufacturers claim the drugs are 70 to 85 percent effective, but research shows their effectiveness to be more in the 50 to 60 percent range; for men with diabetes, heart disease, or high cholesterol or blood pressure, it can be even lower. And wait until you hear how the studies define "effectiveness": We're not talking rock-hard porn-star erections here, but rather any increase in firmness that enables intercourse. That means even drug-fueled erections can be on the soft side, leaving many men feeling disappointed. Bottom line: If you've never tried an erection medication, you're in the majority. But if you use one, you — and your partner — will likely be happiest with one that lasts the longest. For now, according to the latest surveys, that's Cialis. Michael Castleman, publisher of the website GreatSexAfter40.com, writes about sex for AARP. Why long-married couples are splitting up One job where it pays to be in your 60s Affordable Care Act questions? See the AARP home page for deals, savings tips, trivia and more. Posted on 16 May 2016 24 October 2019 by Dr Tony Steele - Dr Fox is a CQC , GPhC , & MHRA regulated service. Both Viagra and sildenafil are widely used to treat erectile dysfunction. Viagra is a brand name for the sildenafil produced and sold by the company Pfizer. Sildenafil is also sold as a generic drug, which is medically identical to Viagra. Sildenafil citrate was created in 1989 by British scientists Albert Wood and Peter Dunn as a possible treatment for hypertension and angina; conditions associated with coronary heart disease. Nicholas Terrett, now often referred to as the father of Viagra, was named in the British patent for the drug as a heart medication. And though Pfizer’s early trials of the drug in the 1990s did not prove its efficacy as a heart medication, patients who took part in the clinical trials reported increased erections after taking sildenafil. Separate studies provided more information on the biochemical process that causes erections, which helped scientists understand how sildenafil could enhance the effects of sexual stimulation and open up blood vessels in the penis. Sildenafil was then studied in men with erectile dysfunction, and in 1998 it was approved by the FDA specifically for treatment of ED. When Pfizer lost its UK patent for the drug in June 2013 it made way for generic manufacturers to produce sildenafil, or ‘generic Viagra’. It costs a fraction of the price of Viagra, and has made the treatment more accessible to a wider range of patients. You can now choose to buy Viagra, Pfizer’s branded drug, or sildenafil, the generic version. Branded Viagra comes in small diamond-shaped blue pills – Pfizer has also patented this pill design and appearance. Sildenafil is sold as white or blue tablets, with different characteristics depending on the brand. Some have chalky finishes while others are smooth, and some are scored for easy division, while others are not. Both Viagra and the different brands of sildenafil can be purchased in 25mg, 50mg, and 100mg preparations, and there is no significant difference between them in terms of active ingredients. Sildenafil tablets can come in many shapes, colours, and sizes – see comparing brands of sildenafil. As a generic medicine, sildenafil is produced by a number of manufacturers, and competition among them helps to regulate its price and keep it affordable for consumers. Branded Viagra is only produced by Pfizer, whose name recognition and customer loyalty allow it to charge a higher price for its renowned ‘little blue pills’. It is a requirement for the generic version to contain the same levels of the active ingredient in the body as its branded alternative, which is known as bioequivalence. Before generic drugs are licensed for sale the manufacturer must demonstrate bioequivalence to the licensing authorities (the European Medicines Agency). If you have a private prescription for Viagra, the branded drug must be dispensed; but you may ask for sildenafil at the time that the prescription is made. They are considered equally effective, however patients must follow proper protocol for optimum results. Also note that if the condition does not respond to the initial dose of Viagra or generic sildenafil, a higher dose may be required (after several unsuccessful attempts). Packaging differences: Viagra 100mg tablets and Mylan sildenafil 100mg tablets. Cialis (tadalafil) and Viagra (sildenafil) are phosphodiesterase-5 (PDE5) inhibitors used for treating impotence (erectile dysfunction, or ED). Common side effects of Cialis include: flushing (redness or warmth of the face, neck, or chest), headaches, stomach upset, diarrhea, flu-like symptoms (such as stuffy nose, sneezing, or sore throat), memory problems, muscle or back pain, nausea, low blood pressure, dizziness, blurred vision and changes in color vision, abnormalejaculation, and prolonged erections (priapism). Common side effects of Viagra include: warmth or redness in the face, neck, or chest, stuffy nose, headaches, stomach pain, upset stomach, nausea, diarrhea, memory problems, back pain, an inability to differentiate between the colors green and blue, loss of hearing, ringing in the ears, and dizziness. Cialis is a prescription medicine taken by mouth for the treatment of: men with erectile dysfunction (ED) men with symptoms of benign prostatic hyperplasia (BPH) men with both ED and BPH. Viagra is a prescription medicine used to treat erectile dysfunction (ED). You will not get an erection just by taking this medicine. Viagra helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated). It is not known if Viagra is safe and effective in women or children under 18 years of age. Do not take Cialis if you: take any medicines called "nitrates". use recreational drugs called "poppers" like amyl nitrite and butyl nitrite. take any medicines called guanylate cyclase stimulators, such as riociguat. are allergic to Cialis or Adcirca, or any of its ingredients. Call your healthcare provider or get help right away if you have any of the symptoms of an allergic reaction listed above. Do not take Viagra if you: take medicines called nitrates (such as nitroglycerin) use street drugs called "poppers" such as amyl nitrate or amyl nitrite, and butyl nitrate take any medicines called guanylate cyclase stimulators such as riociguat (Adempas) are allergic to sildenafil, as contained in Viagra and REVATIO, or any of the ingredients in Viagra. See the end of this leaflet for a complete list of ingredients in Viagra. Tell your healthcare provider about all the medicines you take1, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Viagra may affect the way other medicines work, and other medicines may affect the way Viagra works causing side effects. Especially tell your healthcare provider if you take any of the following: medicines called nitrates (see "What is the most important information I should know about Viagra?") medicines called guanylate cyclase stimulators, such as riociguat (Adempas) medicines called alpha blockers such as Hytrin (terazosin HCl), Flomax (tamsulosin HCl), Cardura (doxazosin mesylate), Minipress (prazosin HCl), Uroxatral (alfuzosin HCl), Jalyn (dutasteride and tamsulosin HCl), or Rapaflo (silodosin). Alpha-blockers are sometimes prescribed for prostate problems or high blood pressure. In some patients, the use of Viagra with alpha-blockers can lead to a drop in blood pressure or to fainting. medicines called HIVprotease inhibitors, such as ritonavir (Norvir), indinavir sulfate (Crixivan), saquinavir (Fortovase or Invirase) or atazanavir sulfate (Reyataz) some types of oralantifungal medicines, such as ketoconazole (Nizoral), and itraconazole (Sporanox) some types of antibiotics, such as clarithromycin (Biaxin), telithromycin (Ketek), or erythromycin other medicines that treat high blood pressure other medicines or treatments for ED. Viagra contains sildenafil, which is the same medicine found in another drug called REVATIO. REVATIO is used to treat a rare disease called pulmonary arterial hypertension (PAH). Viagra should not be used with REVATIO or with other PAH treatments containing sildenafil or any other PDE5 inhibitors (such as Adcirca [tadalafil]). Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine. Take Cialis exactly as your healthcare provider prescribes it. Your healthcare provider will prescribe the dose that is right for you. Some men can only take a low dose of Cialis or may have to take it less often, because of medical conditions or medicines they take. Do not change your dose or the way you take Cialis without talking to your healthcare provider. Your healthcare provider may lower or raise your dose, depending on how your body reacts to Cialis and your health condition. If you take too much cheap generic sildenafil Cialis, call your healthcare provider or emergency room right away. Take Viagra exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Viagra to take and when to take it. Your healthcare provider may change your dose if needed. You may take Viagra between 30 minutes to 4 hours before sexual activity if needed. If you take Viagra after a high fat meal (such as a cheeseburger and french fries), Viagra may take a little longer to start working. If you accidentally take too much Viagra, call your doctor or go to the nearest hospital emergency room right away. Viagra (sildenafil) Viagra is a brand-name prescription drug that’s approved to treat erectile dysfunction (ED). With ED, you’re unable to have or maintain an erection. Viagra is approved for this use in males ages 18 years and older. It belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors. (A class of drugs is a group of medications that act in a similar way.) Viagra works by increasing blood flow to your penis, which helps you have and keep an erection. But this drug only works if you’re sexually aroused. In most cases, it should be taken about an hour before sexual activity, but it can be taken 30 minutes to 4 hours beforehand. Viagra is available in three strengths: 25 mg, 50 mg, and 100 mg. In several clinical studies, Viagra was effective in treating ED. In these studies, men who used the drug had an improved ability to have and keep erections that allowed for successful sex. Across the studies, between 43% and 83% of men who took Viagra had improved erections. (These rates varied depending on the cause of their ED and the dosage of Viagra being used.) In comparison, improved erections occurred in 10% to 24% of men who took a placebo (no active drug). To learn more about Viagra’s effectiveness, see the “Viagra uses” section below.
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