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The main problem with penile implants is that the normal functionality is damaged permanently, meanwhile a devise like PotencyFlow® adds to your exiting functionality. 3 Belsley et al., 1998; Brooks & Jordan, 2001 4 Garber, 2005. Implantica is developing products for the treatment of Erectile Dysfunction (ED). The company is focused on high technology products which are designed to help patients attain a higher quality of life and provide benefits over current existing products by being easier to use and generally more acceptable to the patient population. Formerly known as ‘impotence’, the term Erectile Dysfunction (ED) is now more often used to distinguish it from other problems related with sexual intercourse, e.g. lack of sexual desire or ejaculation and orgasm problems (Brooks & Jordan, 2001). ED is treatable and not a life-threatening disease. However, the condition may result in numerous social and personal problems: depression, withdrawal from sexual intimacy, marital problems, reduced quality of life, decreased working productivity, and increased healthcare utilization (Dhanani et al., 1998, cited by Joyce et al., 2007). With the introduction of Viagra in 1994, the market for erectile dysfunction treatments boomed. Still, many men hesitate to seek help due to the social stigma and embarrassment associated with ED. Erectile Dysfunction was defined at the National Institutes of Health Consensus Conference in Washington DC, US, December 1992 as ‘the inability to achieve an erection satisfactory for sexual intercourse’ (National Institutes of Health, 1993). Satisfaction is determined by both patient and partner, making ED a ‘couple’s disease’. The degree of ED can ... More

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Problems with erections are relatively common in the general population and the cause of your symptoms may be unrelated to MS. Factors that can affect sexual response include: Lifestyle factors, such as drinking too much alcohol, taking drugs, being overweight or smoking. Other medical conditions, such as heart disease, diabetes, high blood pressure or kidney problems. Worries, anxiety or stress about other aspects of your life. Side effects of medication, such as from some anti-depressants or anti-spasticity drugs. Ageing - difficulties with erections are more frequent in older men. Venous leak - a physical condition in which the extra sildenafil 100mg 30 tablets blood in the penis is not retained during an erection. The cause of your symptom may involve several factors, some related to MS and others not. Effective management requires a thorough assessment of all the possible contributing issues. It is estimated that nearly one in five men in the general population has a problem with achieving an erection at some point, either every now and again or sildenafil 100mg 30 tablets more consistently over a prolonged period of time. Erectile dysfunction is thought to be more common amongst men with MS and research suggests anything from one quarter to two thirds of men with MS may be affected at some point. The most important and most powerful starting point for managing sexual issues is a willingness to talk about them. Although there are treatments available that can restore the ability to achieve an erection, the effective management of the symptom requires an assessment of the whole person. For example, if fatigue is affecting your sexual performance, a pill that makes ... More

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From the GEQ, the percentage of MS patients reporting improved erections was 90% for sildenafil users compared with 24% for placebo users; the percentage of SCI patients reporting improved erections was 75% for sildenafil users compared with 7% of placebo users. These data demonstrate that patients with ED due to spinal disease respond well to treatment with sildenafil. The results are comparable to or better than a population of patients with ED of mixed etiology (72–79%) 23 and markedly higher than in patients with diabetes mellitus (48–72%), 24 whose poorly preserved vasculature might be the main reason for low efficacy. Interestingly, there appears to be a greater efficacy of sildenafil in patients with MS than in patients with diabetes, since 64% of men with MS preferred the 100 mg dose, compared with 75% of men with diabetes choosing that dose. Moreover, greater efficacy in patients with MS may be due to the fact that sildenafil acts peripherally, and although pyschogenically driven erections are likely to have been impaired by spinal cord disease, reflexogenic responses, subserved by sacral segmental pathways, are still intact. The average age of patients in this study is relatively young and with healthy peripheral neurovasculature a good erectile response is obtained by reflex mechanisms and what psychogenic responsiveness remains available. Sildenafil was well tolerated in this study, as the majority of AEs reported during both phases were mild to moderate in severity and non-serious. AEs were those known to be associated with the mechanism of action of sildenafil, such as headache, vasodilation, and dyspepsia. The following clinical investigators contributed ... More

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This pathway is active in numerous organ systems, and as of this writing, a number of different PDEs are known. The various PDEs differ in their physiologic roles and tissue distribution. Type 5 PDE is concentrated in the penile smooth muscle of the corpus cavernosum, where its normal function is to inhibit erection by degradation of cGMP, the mediator of erection. Viagra and the new drugs Cialis and Levitra all inhibit PDE-5, which is an inhibitor for corporal smooth muscle relaxation, resulting in increased blood flow in the penis in response to sexual stimulation. Comparison of Viagra, Cialis, & Levitra No head-to-head trial comparing the 3 PDE inhibitors has been performed. However, some differences between the 3 are basic: a table has been created to illustrate the major differences. An obvious proviso is that extensive data are available on Viagra (more than 20 million men treated, more than 1100 peer-reviewed articles as of Feb. Tubingen in Germany have compared the three drugs via literature review (Eur. 7:435, 2002) In brief, efficacy is approximately 70% with all 3 drugs. The side effect profile is similar among the 3 drugs, except that blue discoloration of vision (overlap with PDE-6 in the retina) is seen only with Viagra ( generic viagra pills for sale Peer-reviewed References. Tadalafil and vardenafil are phosphodiesterase-5 (PDE5) inhibitor used to treat impotence (the inability to attain or maintain a penile erection) Tadalafil is also used to treat symptoms of benign prostatic hyperplasia (BPH). Brand names for tadalafil include Adcirca and Cialis. Brand names for vardenafil include Levitra and Staxyn ODT. Side effects of tadalafil and vardenafil that ... More

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Usually, they were boys between the age of 20-25 and cardiovascular diseases were not typical for them, so, a study was conducted, which found out that cocaine negatively affects the blood circulation and, in some cases, can cause spasms of the coronary vessels. To remove these side effects, many viagra cheap generic young people started taking Viagra, often mixing it with the popular Ecstasy. Such a mix was called “ Sextasy “, but the effect differed from the originally expected, as the simultaneous spasms of blood vessels and increased blood flow can hardly be called healthy. Many people still believe that ED pills such as Viagra are prescribed only to elderly men. However, earlier the PDE5 inhibitor was advertised as a tool for middle-aged men, the heroes of today’s commercials and articles are men under 40. And it doesn’t mean that potency problems start earlier nowadays. Drugs, such as Generic Viagra gave the opportunity to experience full and bright life, now they are taken not only as pills for erectile dysfunction treatment but as a means of pleasure prolonging. Generic Viagra really helps men suffering from erectile dysfunction – these are men with diabetics and different kinds of neurological disorders, those who had been taking antidepressants for a long time (erectile dysfunction is a side-effect of antidepressants). Viagra is usually taken by men, who have not yet faced a similar problem but would like to insure. Especially in those cases, when they are expecting an important event. Well, the drug really gives the opportunity to feel more confident. However, their administration can be combined with food and drinks, so the Viagra tablet can be discreetly ... More

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Chattipakorn N, Fotuhi PC, Sreenan CM, White JB & Ideker RE (2000). Pacing after shocks stronger than the upper limit of vulnerability: impact viagra super active coupon on fibrillation induction. Influence of postshock epicardial activation patterns on initiation of ventricular fibrillation by upper limit of vulnerability shocks. Chattipakorn N, Banville I, Gray RA & Ideker RE (2001). Mechanism of ventricular defibrillation for near-defibrillation threshold shocks: a whole-heart optical mapping study in swine. Chattipakorn N, Fotuhi PC, Chattipakorn SC & Ideker RE (2003). Three-dimensional mapping of earliest activation after near-threshold ventricular defibrillation shocks. Journal of Cardiovascular Electrophysiology , 14: 65-69. Pediatric Clinics of North America , 51: 1211-1221. Pacing following shocks stronger than the defibrillation threshold: impact on defibrillation outcome. Journal of Cardiovascular Electrophysiology , 11: 1022-1028. Prediction of defibrillation outcome by epicardial activation patterns following shocks near the defibrillation threshold. Journal of Cardiovascular Electrophysiology , 11: 1014-1021. Chattipakorn N, Banville I, Gray RA & Ideker RE (2004). Effects of shock strengths on ventricular defibrillation failure. Sildenafil in patients with cardiovascular disease. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Alloggiamento T, Zipp C, Raxwal VK, Ashley E, Dey S, Levine S & Froelicher VF (2001). Padma-Nathan H, Eardley I, Kloner RA, Laties AM & Montorsi F (2002). A 4-year update on the safety of sildenafil citrate (Viagra). McGovern PG, Jacobs Jr DR, Shahar E, Arnett DK, Folsom AR, ... More

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