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As drug development costs continue to rise and the level of attrition for new drug candidates remains intimidating, the search for new therapeutic agents within oncology has become increasingly challenging.

Researchers both within and outside of the pharmaceutical industry will occasionally look at certain non-chemotherapeutic medications that have been in the market for a substantial amount of time for “off-label” indications within oncology. It is more typical for researchers to examine generic medications (as opposed to those still on-patent) based on the idea that there may be fewer potential legal blockades with generic therapies.

This type of strategy is sometimes called “repurposing” a medication.

These medications typically have years of safety and efficacy data that helps reduce some of the financial burden associated with developing a new drug. One such medication that may have a role within oncology is the popular erectile dysfunction drug sildenafil.

Sildenafil works as a phosphodiesterase (PDE)-5 inhibitor, which increases levels of nitric oxide using cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). 1 There is some preclinical evidence to support its antineoplastic properties, both in vitro and in vivo, with most of the data occurring within animal models. 2 There are several mechanisms by which PDE5 inhibitors could express antineoplastic effects. PDE-5 inhibition has been shown to upregulate apoptosis in several different cell lines.

2,3 The apoptotic effect has been demonstrated within multiple cancers including prostate cancer, colorectal cancer (CRC), chronic lymphocytic leukemia (CLL), breast cancer, multiple myeloma, and melanoma. In addition to apoptosis, PDE5 inhibition has also been associated with enhanced T-cell response against tumors and anti-inflammatory properties. Recently, a study evaluated the effect of sildenafil and linaclotide (a guanylyl-cyclase C agonist) on intestinal tumorigenesis in mice.

4 When compared with water controls, the study found a significant reduction in the number of polyps per mouse by 50% and 67%, respectively ( P 5 Sildenafil was shown to lower serum immunoglobulin M (IgM) levels and induce apoptosis of certain B cells in these patients.

A larger, follow-up study to this found that 63% (19/30) patients treated with sildenafil had lower serum IgM levels and lack of disease progression. Sildenafil Use and the Risk of Melanoma Do Clinical Trials Overstate New Cancer Drugs' Survival Benefits? ASTRO: Daily Sildenafil During RT Improves Sexual Function in Patients with Prostate Cancer. In addition to antineoplastic data, there have also been limited reports of a link between PDE5 inhibitors and an increased risk of certain types of cancer.

An increased risk of melanoma (HR = 1.92, 95% CI 1.14-3.22) was reported in a large prospective cohort study conducted by Li and colleagues.

7 This increased risk was not seen in basal or squamous cell carcinoma. It was postulated that reduced expression of PDE5A could lead to increased invasiveness of melanoma cells. 7,8 Subsequent studies have showed lower hazard ratios and lack of dose response. 2 Therefore, much of the current opinion is that there is lack of evidence to support causality. In addition, there was initially some concern regarding biochemical recurrence of prostate cancer after radical prostatectomy and long-term PDE5 inhibitor use, however, more recent studies have actually shown a potential protective effect.

Viagra is the brand name for a medicine known as Sildenafil which has been proven to be effective for the treatment of erectile dysfunction.

Sildenafil is the active ingredient and has also been available since 2013 as a generic drug. A generic drug contains the same active ingredient as a branded drug and is medically equivalent but can be produced by any generic manufacturer. History – Pfizer Loses Patent in 2013 on Viagra Allowing Generic Viagra (Sildenafil) Viagra was one of the first treatments to be approved for the treatment of erectile dysfunction and has been used by men across the world for over a decade with excellent results. Pfizer was the original manufacturer for Viagra and developed a patent on the product in 1996.

Originally Viagra was used for the treatment of heart disease, but during clinical trials it was noticed that it also helped treat erectile dysfunction. In 1998, Pfizer received FDA approval to license the product for the treatment of erectile dysfunction. In 2013, the Pfizer patent on Viagra ended in the EU, allowing generic manufacturers to start producing their own version.

The generic version of the drug is known as Sildenafil which is the active ingredient in Viagra.

The name Viagra is still a brand name which only Pfizer can use. So effectively in the market the drug can be bought as either the branded Pfizer product Viagra, or the generic drug Sildenafil.

Pfizer, as well as holding the rights to use the brand name Viagra, has a patent on the unique blue diamond appearance of Viagra. For many people, Viagra is known as “the little blue pill” and this is still associated with only the branded Pfizer product.

The appearance of the product is purely cosmetic and has no medical difference. Sildenafil is a generic drug which means that its price is not controlled by a single manufacturer. As several manufacturers produce Sildenafil, the market is very competitive which viagra no prescription cheap has helped drive down the price substantially. Viagra on the other hand is produced only by Pfizer who control the price without any competition. As Viagra is a well known brand name, Pfizer are able to charge a premium price.

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Viagra has been proven to be a very effective treatment for erectile dysfunction with over 80 percent of men finding it works for them. Sildenafil is produced by several manufacturers and contains the exact same medical ingredient and dosage as the branded Viagra counterpart. To receive market approval, a generic medicine must be ‘bioequivalent’ to the branded product which ensures that the generic product has the same effectiveness. As a result you can be confident that the Sildenafil sold in the UK is as effective as the branded Viagra tablets.

Transient ischemic attack and stroke associated with sildenafil (Viagra) use. Find this author on Google Scholar Find this author on PubMed Search for this author on this site. Find this author on Google Scholar Find this author on PubMed Search for this author on this site. BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero.

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Sildenafil citrate (Viagra; Pfizer US Pharmaceutical Group, New York, NY) is prescribed for millions of men with erectile dysfunction. There are well-known risks of cardiovascular events in patients taking sildenafil concomitantly with organic nitrates.

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