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Condition or disease Intervention/treatment Phase Fatigue Drug: Sildenafil Drug: tadalafil Drug: Placebo Not Applicable.

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For general information, Learn About Clinical Studies.

Layout table for eligibility information Ages Eligible for Study: 50 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes.

Age 50-60 years of age Ability to sign consent form (score>23 on the 30-item Mini Mental Status examination, MMSE) Stable body weight for at least three months.

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Dosing information Not applicable [13] Contraindications. Sildenafil tablets are contraindicated in patients with : Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of hypotension. Known hypersensitivity to sildenafil or any component of the tablet.

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Use of sildenafil citrate, particularly chronic use, is not recommended in children. Sildenafil citrate has vasodilatory properties, resulting in mild and transient decreases in blood pressure. Before prescribing sildenafil citrate, carefully consider whether patients with certain underlying conditions could be adversely affected by such vasodilatory effects (e.g., patients on antihypertensive therapy or with resting hypotension [BP less than 90/50], fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction).

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The incidence of epistaxis was 13% in patients taking sildenafil citrate with PAH secondary to CTD. This effect was not seen in idiopathic PAH (sildenafil citrate 3%, placebo 2%) patients.

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