Sildenafil 200mg price

Two

independent

The methodological quality was assessed using the Jadad score, with a Jadad score ?3 indicating a high-quality article [16].

Data extractions were performed by one reviewer and checked by a second reviewer. Information was extracted from the studies that met the above-mentioned inclusion criteria using a structured form.

The first author, publication year, sample size, therapy that the patients received and assessment indices, including the IIEF, the men’s preference, the Self-Esteem and Relationship questionnaire (SEAR), total Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) scores and TEAEs, were collected for each study. A meta-analysis of comparable data was performed using RevMan 5.0. Statistical heterogeneity between studies was assessed using the I 2 statistic. Pronounced heterogeneity was indicated by a P value ?0.05 and an I 2 value ?50%; in these cases, a randomized effects model was executed. A P value ?0.05 and I 2 ? 50 indicated no obvious heterogeneity between the studies, and a fixed effects model was chosen for the meta-analysis.

Continuous data are presented as weighted mean differences (WMDs), and odds ratios (ORs) were calculated for sildenafil 200mg price dichotomy [both with 95% confidence intervals (CIs)].

Egger’s test was performed to evaluate the risk of publication bias. Additionally, a sensitivity analysis was performed to assess the stability of the outcome when low-quality and highly heterogeneous trials were included in the analysis. A total of 1657 articles were identified through the electronic databases and the manual review of the reference lists of the included studies.

Based on the search strategy, a total of 16 studies were included in the review [17–31].

A total of 5189 patients were recruited in the final meta-analysis, and the mean patient age ranged from 36.9 to 56.2 years. Seven articles were open-label, randomized, multicentre, controlled studies; nine of the studies had a crossover design; and the other studies were prospective and observational.

The common instruments used to assess these two PDEIs (sildenafil and tadalafil) were the IIEF-EF, preference, TEAEs, adherence and persistence.

The characteristics of the studies are listed in Table 1 . Author Year Number Intervention Control Assessment Jadad score Bai et al.

2016 383 Tadalafil: 20 mg Sildenafil: 100 mg preference, TEAEs 2 Buvat et al.

2013 770 Tadalafil: 5 mg OaD, 10 mg PRN Sildenafil: 50 mg PRN IIEF score, TEAEs 2 Helen et al. 2008 100 Tadalafil: 20 mg Sildenafil: 100 mg Preference, IIEF-EF, TEAEs 2 Eardley et al. 2005 291 Tadalafil: 10 mg, 20 mg Sildenafil: 25,50,100 mg Preference, IIEF, cvs price for sildenafil TEAEs 2 Govier et al. 2003 215 Tadalafil: 20 mg Sildenafil: 50 mg Preference, TEAEs 3 Hatzimouratids et al.

2014 770 Tadalafil: 2.5, 5 mg OaD; 10, 20 mg PRN Sildenafil: 25, 50, 100 mg PRN IIEF 3 Rubio-Aurioles et sildenafil citrate 100mg tab price al. 2012 418 Tadalafil: 5 mg OaD, 20 mg PRN Sildenafil: 100 mg sildenafil tablet buy online PRN IIEF, TEAEs 2 Rodriguez Tolra et al.

2006 90 Tadalafil: 20 mg Sildenafil: 50 mg, vardenafil: 20 mg IIEF, preference, TEAEs 2 Von Keitz et al.

2004 265 Tadalafil: 20 mg Sildenafil: 50 mg preference, TEAEs 3 Li et al. 2016 63 tadalafil: 20 mg sildenafil: 100 mg preference, IIEF 2 Cairol et al.

2014 104 Tadalafil Sildenafil, vardenafil, lodenafil IIEF, persistence and adherence 2 Stroberg et al.

2003 147 Tadalafil: 20 mg Sildenafil: 25, 50, 100 mg preference, TEAEs 2 Ahn et al.

2007 160 Tadalafil: 20 mg Sildenafil: 50, 100 mg preference, TEAEs 2 El-Meliegy et al. 2013 493 Tadalafil Sildenafil, vardenafil persistence, adherence, IIEF, 2 Taylor et al. 2009 409 Tadalafil Sildenafil, vardenafil TEAEs 2 Rubio-Aurioles et al. 2013 511 Tadalafil Sildenafil, vardenafil persistence, adherence IIEF 2. TEAE treatment–emergent adverse events, IIEF International Index price of sildenafil at walmart of Erectile Function, OaD once a day, PRN on demand. Egger’s test was conducted to assess the presence of possible publication bias.

No evidence of publication bias was found for the IIEF-EF, preference, overall adverse events, back pain, dyspepsia, nasopharyngitis, adherence and persistence (Egger’s test P ? 0.05). The Egger’s test results found publication bias for headache, flushing and nasal congestion ( P ? 0.05). The other parameters were not evaluated using Egger’s test because only two studies included relevant data (Tables 2 , ? ,3; 3 ; Figs. Study quality was evaluated with the Jadad scoring system, and the results are shown in Table 1 .

According to a recent network meta-analysis published in 2015 that indirectly compared the efficacy and safety of PDEIs, sildenafil had the greatest efficacy but the highest rate of overall adverse events, whereas tadalafil had intermediate efficacy and the lowest overall rate of all adverse events [15]. However, our study, which differs from previous systematic reviews, is the first meta-analysis to directly compare the efficacy and safety of sildenafil and tadalafil. PDE5-Is selectively block the PDE5 enzyme, which catalyses the hydrolysis of cGMP to GMP and thus prolongs erectile function [32]. PDEIs are the most commonly used drugs to treat ED, and the effects of the PDEIs used to treat ED have been investigated. The IIEF is a widely used, validated and sildenafil 200mg price self-administered questionnaire that has demonstrated a high degree of sensitivity and specificity for the assessment of ED [33].