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Vardenafil, also known by the brand name Levitra, is a prescription medication that treats male erectile dysfunction.

Erectile dysfunction is when a man is unable to get or sustain an erection. It usually happens because the arteries that carry the blood to the penis are too narrow. Its action is similar to that of sildenafil, or Viagra, but Viagra lasts between 2 and 4 hours, while Levitra lasts 4 hours.

Share on Pinterest Vardenafil can help a man get and maintain an erection. During a penile erection, the penis fills with blood.

The blood vessels that supply the penis with blood expand, or dilate, and the vessels that take blood away from the penis contract. The two large chambers in the penis, known as the corpus cavernosa, fill with blood. As the blood accumulates in the penis, an erection results.

Vardenafil belongs to a class of cialis cheap no prescription drugs called phosphodiesterase type-5 (PDE5) inhibitors.

A PDE5 inhibitor stops PDE5 from constricting the arteries. By relaxing the arteries, vardenafil enhances blood flow when a man is sexually aroused.

The active ingredient works on the chain of reactions within the penis during arousal. When a male is sexually aroused, nitric oxide is released into his penis, and this triggers a chain of reactions.

This causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). cGMP regulates the contraction and dilation, or expansion, of blood vessels that carry blood to and from the penis. The chemical reaction causes the vessels that supply the penis to dilate, while those removing blood from the penis contract.

Phosphodiesterase-5 (PDE5), another enzyme breaks down or destroys cGMP. When cGMP is destroyed, the blood vessels return to their normal size, effectively ending the erection.

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Students can find additional information in the Undergraduate Student Guide and Graduate & Professional Student Guide.

Goals Center for Sexual Medicine Faculty and Staff Make an Appointment For Health Care Professionals Training Opportunities. The most common sexual dysfunctions in men include lack of interest, premature ejaculation and erectile dysfunction. The latter affects 52% of men between the ages of 40 and 70, including mild, moderate and complete forms of ED. Organic or physical causes for sexual dysfunction in men include vascular, hormonal and neurologic factors.

Concerning vascular causes, the risk factors for atherosclerosis (including smoking, high blood pressure, diabetes (diabetics do not respond well to pills like sildenafil (Viagra)) and high cholesterol are ALSO risk factors for erectile dysfunction. Since a straddle injury or use of a narrow saddle can obstruct and impair arteries to the penis, bicycle riding is also considered a risk factor for erectile dysfunction. Little attention has been paid to endocrine factors.

Testosterone modulates desire, arousal and orgasmic function. Concerning the orgasmic response, testosterone modulates the integrity of genital sensory receptors.

Concerning the arousal response, decreased testosterone blood levels can influence the efficacy of sildenafil (Viagra).

If the sildenafil response is not reliably improving erection, the physician should first check if the patient is taking the pill correctly.

The physician should also check the patient’s testosterone level.

One investigator in Italy gave testosterone to patients with low testosterone who did not respond to sildenafil (Viagra).

When daily testosterone was given, subsequent sildenafil (Viagra) use resulted in IIEF (the International Index of Erectile Function questionnaire used to determine erectile function) scores improving significantly. Other risk factors for erectile dysfunction include neurologic problems (multiple sclerosis, stroke), depression and medications for treating diabetes, hypertension, heart disease and depression.

There are many oral therapies for erectile dysfunction, but the only approved medication in the US is the PDE 5 enzyme inhibitor sildenafil (Viagra).

Unapproved therapies, some of which are available in the US and some elsewhere, some of which have data to prove efficacy and some not, include tadalafil (Cialis), vardenafil (Levitra), yohimbine, phentolamine, trazodone, apomorphine and neutraceuticals. PDE5 inhibitors act to relax penile erectile tissues with sexual stimulation thus enhancing your ability to get an erection.