Sildenafil price 50 mg

Also, patients on concomitant treatment with nitrates or calcium channel blockers or with severe hepatic impairment were excluded.

A total of 267 patients with distal ureteric stones were assessed for eligibility to enter the study. One hundred and sixty-five patients were excluded for different reasons (not meeting inclusion criteria 70 patients, refused to participate 54 patients and for other reasons 41 patients) as in Fig.

One hundred and two patients who fulfilled the inclusion criteria were enrolled in the study.

Informed written consent was obtained from all the patients after explanation of the study procedures and the possible side effects. The patients were randomly divided into 3 equal groups, and each one consists of 34 patients using closed envelope method. Group I received silodosin 8 mg once daily, group II vardenafil 5 sildenafil price 50 mg mg once daily and group III combination of silodosin 8 mg and vardenafil sildenafil price 50 mg 5 mg once daily.

The treatment was given for all the patients until stone expulsion or a maximum of 4 weeks. Patients were assessed by history taking, general examination, serum creatinine, urine analysis, urine culture, KUB (kidney, ureter and bladder X-ray) and non-enhanced spiral CT.

Patients were advised to take diclofenac 75 mg tablet orally during pain episodes along with the allocated drug.

Patients were instructed to filter their urine to detect any passed stones.

Our study was planned as a double-blind study, and both the investigators and the participants were unaware of the type of the treatment received.

Follow-up was performed weekly by history taking (stone passage, number of hospital visits for pain, total analgesia required and side effects associated with MET) and ultrasonography until spontaneous passage of the stone or stoppage of MET after 4 weeks. The sildenafil price 50 mg primary endpoint was the stone expulsion rate, and the secondary endpoints were time to stone expulsion, number of hospital visits for pain, amount of analgesic required and side effects associated with MET.

Data was collected, revised, coded and entered into the Statistical Package for Social Science (IBM SPSS) version 23.

Normality of data was checked using Kolmogorov–Smirnov test for normality.

The comparison between groups regarding qualitative data was done by Chi-square test . The comparison between more than two independent groups with quantitative data and parametric distribution was done by one-way ANOVA test. There was no statistically significant difference between the groups for patient’s age, stone site and stone size ( P > 0.05) as in Table 1. The stone expulsion rate was significantly higher in combination than silodosin and vardenafil groups ( P = 0.025), the time to stone expulsion was significantly shorter in combination than silodosin and vardenafil groups ( P Table 2 Comparison between 3 groups regarding stone expulsion rate, stone expulsion time, number of hospital visits for pain and amount of analgesic required. There was no significant difference among the studied groups regarding headache ( P = 0.749), dizziness ( P = 0.856), orthostatic

hypotension

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