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Share your location or enter your city or zip code to find studies near you. sildenafil (injection) Pronunciation: sil DEN a fil.

What is the most important information I should know about injectable sildenafil? Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas).

Do not use sildenafil if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers." Using sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Do not use sildenafil injection with Viagra similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra).

Tell your doctor about all medications you use for erectile dysfunction.

Get emergency medical help if you have ringing in your ears, sudden hearing loss, or sudden vision loss. Sildenafil relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

Sildenafil injection (Revatio) is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Another brand of sildenafil sildenafil citrate 20 mg price is Viagra , which is used to treat erectile dysfunction (impotence) in men. Revatio is used to treat PAH in both men and women. Do not use sildenafil injection while also taking Viagra or other erectile dysfunction medications, unless your doctor tells you to. Sildenafil injection may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using injectable sildenafil? You should not use sildenafil injection if you are allergic to it, or: if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas). Do

not

use sildenafil injection if you are also taking a nitrate drug for chest pain or heart problems.

This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.

Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers").

Using sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure this medicine is safe for you, tell your doctor if you have ever had: heart disease or heart rhythm problems, angina (chest pain), coronary artery disease, circulation problems; a condition called pulmonary veno-occlusive disease; a heart attack, stroke, or congestive heart failure; high or low blood pressure; liver or kidney disease; a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia; a sildenafil citrate 20 mg price bleeding disorder such as hemophilia; a stomach ulcer; retinitis pigmentosa (an inherited condition of the eye), or a history of vision loss; a physical deformity of the penis (such as Peyronie's disease). Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss.

This has occurred in a small number of people using sildenafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear

whether

sildenafil is the actual cause of vision loss.

This medicine is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby. Do not give this medication to anyone under 18 years old without medical advice. This medicine is injected into a vein through an IV.

Do not self-inject sildenafil if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Sildenafil injection is usually given three times each day.

Do not use this medicine in larger or smaller amounts or for longer than recommended. Prepare your dose only when you are ready to give an injection.

Do not use if the medicine has changed colors or has particles in it.

Use a disposable needle only once, then throw away in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Vomiting, diarrhea, or heavy sweating can cause you to become dehydrated. These conditions may cause very low blood pressure.

Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. Store at room temperature away from moisture and heat. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using injectable sildenafil? Avoid using other medicines to treat impotence without your doctor's advice.

What are the possible side effects of injectable sildenafil?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using sildenafil and get emergency medical help if you have: heart attack symptoms --chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; or erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis). Call your doctor at once if you have: ringing in your ears, or sudden hearing loss; irregular heartbeat; swelling in your hands, ankles, or feet; shortness of breath; or a light-headed feeling, like you might pass out. Common side effects may include: nosebleed; headache; upset stomach; flushing (warmth, redness, or tingly feeling); sleep problems (insomnia); or runny or stuffy nose. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088. What other drugs will affect injectable sildenafil? Do not use Revatio with Viagra or similar medications such as avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra).

Tell your doctor about all medications you use for erectile dysfunction. Tell your doctor about all your current medicines and any you start or stop using, especially: drugs to treat high blood pressure or a prostate disorder; an antibiotic --clarithromycin, erythromycin, or telithromycin; antifungal medicine --ketoconazole or itraconazole; or medicine to treat HIV/AIDS --atazanavir, indinavir, ritonavir, or saquinavir.

Other drugs may interact with sildenafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Your pharmacist can provide more information about sildenafil injection. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc.

('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect.

Drug information contained herein may be time sensitive.

Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

oral suspension (Revatio) 10mg/mL (when reconstituted) Erectile Dysfunction. 1 hr before sexual activity; however, may be taken anywhere from 30 min to 4 hr before sexual activity.

Based on effectiveness and toleration, may increase dose to maximum of 100 mg or decrease to 25 mg. IV: 2.5-mg or 10-mg bolus TID if patient is temporarily unable to take PO. Adding Revatio to bosentan does not have any beneficial effect on exercise capacity.

Severe (eg, cirrhosis): Consider initial dose of 25 mg. Mild or moderate (Child-Pugh A or B): Clearance reduced, resulting in increases in AUC (84%) and Cmax (47%) compared to age-matched volunteers with no hepatic impairment Severe (Child-Pugh C): Not studied. Mild or moderate (CrCl 30-80 mL/min): No dose adjustment required Severe (CrCl Enter a drug name and sildenafil.

Vaso-occlusive crisis (PAH secondary to sickle-cell anemia) Nonarteritic anterior ischemic optic neuropathy (NAION) Warnings. Soluble guanylate cyclase (sGC) stimulators (eg, riociguat); concomitant use can cause hypotension.

Coadministration with nitrates (either regularly and/or intermittently) and nitric oxide donors Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined. Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. Use with caution in patients with anatomic deformation of penis (eg, angulation, cavernosal fibrosis, or Peyronie disease), conditions potentially predisposing to priapism (eg, sickle cell anemia, multiple myeloma, or leukemia), cardiovascular disease, bleeding disorders, active peptic ulcer disease, liver disease, renal impairment, multidrug antihypertensive regimens, retinitis pigmentosa, concomitant use of CYP3A4 inhibitors. Pulmonary vasodilators may significantly worsen cardiovascular status of patients with pulmonary veno-occlusive disease. Patient taking alpha blocker should be stabilized before starting phosphodiesterase (PDE)-5 inhibitor, which should be initiated at lowest dose; if patient is already taking optimized dose of PDE-5 inhibitor, alpha blocker should be initated at lowest dose to avoid hypotension. Sudden decrease or loss of hearing, which may be accompanied by tinnitus and dizziness. Viagra: Patients should stop sildenafil and seek medical care if a sudden loss of vision occurs in 1 or both eyes, which could be a sign of nonarteritic anterior ischemic optic neuropathy (NAION); use with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION; patients with a ”crowded” optic disc may also be at an increased risk of NAION; advise patients to seek immediate medical attention in the event of a sudden loss of vision.

Viagra: Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status. May cause dose-related impairment of color discrimination; use caution in patients with retinitis pigmentosa.

Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy.

Revatio: In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known. Revatio: Not for use in children with PAH; increased mortality with increasing doses (hazard ratio 3.5) was observed in randomized, double-blind, placebo-controlled clinical trial of 234 children (1-17 years) with PAH who had mild-to-moderate symptoms at baseline.

Revatio: Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (eg, scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%) Pregnancy & Lactation. Limited published data from randomized controlled trials, case-controlled trials, and case series do not report a clear association with sildenafil and major birth defects, miscarriage, or adverse maternal or fetal outcomes when sildenafil is used during pregnancy; there are risks to mother and fetus from untreated

pulmonary

arterial hypertension. Pregnant women with untreated pulmonary arterial hypertension are at risk for heart failure, stroke, preterm delivery, and maternal and fetal death. Limited published data from a case report describe presence of sildenafil and its active metabolite in human milk; there is insufficient information about effects of sildenafil on breastfed infant and no information on effects of sildenafil on milk production; limited clinical data during lactation preclude a clear determination of risk of drug to an infant during lactation.

Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available.

Uses Side Effects Precautions Interactions Overdose Images Uses Side Effects Precautions Interactions Overdose Images.

Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.

This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Consult your doctor or pharmacist for more details. Read the Patient Information Leaflet provided by your pharmacist before you start taking sildenafil and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Take sildenafil at least 30

minutes

, but no more than 4 hours, before sexual activity (1 hour before is the most effective).

A high-fat meal may delay how quickly the drug begins to work. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if your condition does not improve. Dizziness, headache, flushing, or stomach upset may occur.

Vision changes such as increased sensitivity to light, blurred vision, or trouble telling blue and green colors apart may also occur.

If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Many people using this medication do not have serious side effects. Sexual activity may put extra strain on your heart, especially if you have heart problems.

If you have heart problems and experience any of these serious side effects while having sex, stop and get medical help right away: severe dizziness, fainting, chest/jaw/left arm pain, nausea. Rarely, sudden decreased vision, including permanent blindness, in one or both eyes (NAION) may occur. If this serious problem occurs, stop taking sildenafil and get medical help right away.

You have a slightly greater chance of developing NAION if you have heart disease, diabetes, high cholesterol, certain other eye problems ("crowded disk"), high blood pressure, if you are over 50, or if you smoke.



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