Generic viagra soft tabs 100mg

This means that a lot is known about its effects and side effects.

It works within an hour of taking a tablet, and is best taken on an empty stomach. The effects of Viagra will last for four to six hours.

Viagra was developed and originally marketed by the pharmaceutical company Pfizer, and until 2013 Pfizer was the only company allowed to sell it. When Pfizer’s patent on Viagra expired, the market was open for other companies to produce the medicine, albeit under its generic name Sildenafil, rather than the brand name Viagra. Sildenafil contains exactly the same active ingredient as Viagra (sildenafil citrate), and works in the same way.

However, because it is the generic version of the medicine, rather than the brand, Sildenafil is considerably cheaper. Levitra will last for a similar amount of time as Viagra (four to six hours). The main difference to Viagra is that Levitra tends to be less affected by food or alcohol so can be taken with meals.

There is also some evidence that Levitra is more effective in diabetics than other erectile dysfunction medicines.

The effects of Cialis (tadalafil) last much longer than those for Viagra or Levitra (up to 36 hours) so many men prefer it as involves less planning.

The downside is that if you do experience side effects these can last for longer too. Like Levitra, Cialis is not affected much by food, so can be taken after a meal.

Different erectile dysfunction medicines suit different people, but it is difficult to tell which one will be best for you until you have tried them all. While a particular erectile dysfunction medicine may not work for you first time round, we recommend taking it at least eight times before giving up and trying another.

This is because it can often generic viagra soft tabs 100mg take this long to determine whether or not a medicine is right for you.

We also often suggest that men initially try all three erectile dysfunction medicines to see which is best for them, and we offer a

starter

All three have similar side effects – headaches, stuffy nose, facial flushing, stomach ache or back pain being the most common. Some men who have had bad side effects with, say, Viagra will have fewer generic viagra soft tabs 100mg with Levitra or Cialis, but similarly some find the prolonged side effects of Cialis troubling. Viagra, Cialis and Levitra should not be taken by men who take medicines or recreational drugs containing nitrates. Cialis should not be taken by men who are on medicines called alpha blockers which are sometimes used to treat prostate problems or high blood pressure. Men who take alpha blockers can use Viagra or Levitra but must allow at least a six hour gap between taking the alpha blocker and Viagra or Levitra.

Viagra, Levitra and Cialis all work in a similar way. They all relax the blood vessels which supply blood to the penis, meaning that more blood can get there when aroused.

These medicines are not aphrodisiacs, so you will still need to be sexually stimulated in order to get an erection. Sildenafil and Spedra are two other major erectile dysfunction medicines which work in a similar way to Viagra, Cialis and Levitra. As outlined above, Sildenafil is the generic version of Viagra, and contains the same active ingredient. Out of the five, Spedra is the newest medicine on the market, and takes the shortest amount of time to work – just 15 minutes in some men.

If your ED has a psychological cause, such as stress, anxiety or depression, counselling can be an effective treatment. This usually takes the form of either couples’ psychosexual counselling, or one-on-one sessions with a psychosexual counsellor.

Sometimes even just talking over the issues with a trained professional can help treat the problem.

It can be a while before any effects from counselling are seen, so it is often combined with prescription medicines such as Viagra, Cialis or Levitra which treat ED in the buy female viagra pills short term. For more information on these and other treatments for erectile dysfunction, see our medical article Erectile Dysfunction Treatments. Is it safe to buy Viagra, Cialis and Levitra online? When buying Viagra, Cialis or Levitra online it’s important to ensure that you are getting them from a trustworthy source like LloydsPharmacy Online Doctor.

There are lots of websites offering erectile dysfunction medicines but many supply fake or counterfeit medicines. Apart from the fact that these medicines may not work, there is also the risk of potentially serious adverse effects from taking non-genuine medicines.

LloydsPharmacy Online Doctor only provides medicines that have been licensed by the government’s Medicines & Healthcare Products Regulatory Agency (MHRA), which means that they have passed rigorous testing before being clinically approved for patients. All our doctors are registered with the General Medical Council, and as a company we are regulated by the Care Quality Commission. LEVITRA ® (vardenafil hydrochloride) Tablets, for Oral Use. LEVITRA (vardenafil hydrochloride) is administered orally for the treatment of erectile dysfunction.

This monohydrochloride salt of vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1- f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water. LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on

one

LEVITRA ® is indicated for the treatment of erectile dysfunction. For most patients, the recommended starting dose of LEVITRA is 10 mg, taken orally, as needed, approximately 60 minutes before sexual activity.

The dose may be increased to a maximum recommended dose of generic viagra soft tabs 100mg 20 mg or decreased to 5 mg based on efficacy and side effects.

The maximum recommended dosing frequency is once per day.

Sexual stimulation is required for a response to treatment. A starting dose of 5 mg LEVITRA should be considered in patients ? 65 years of age [see Use In Specific Populations ].

For patients with moderate hepatic impairment (Child-Pugh B), a starting dose of 5 mg LEVITRA is recommended. The maximum dose in patients with moderate hepatic impairment should not exceed 10 mg. Do not use LEVITRA in patients with severe hepatic impairment (Child-Pugh C) [see WARNINGS AND PRECAUTIONS , Use In Specific Populations and CLINICAL PHARMACOLOGY ].

Concomitant use with nitrates and nitric oxide donors in any form is contraindicated [see CONTRAINDICATIONS ]. Guanylate Cyclase (GC) Stimulators, such as riociguat: Concomitant use is contraindicated [see CONTRAINDICATIONS ]. The dosage of LEVITRA may require adjustment in patients receiving potent CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, atazanavir, and clarithromycin as well as in other patients receiving moderate CYP3A4 inhibitors such as erythromycin [see DRUG INTERACTIONS ].

For ritonavir, a single dose of 2.5 mg LEVITRA should not be exceeded in a 72-hour period. For indinavir, saquinavir, atazanavir, ketoconazole 400 mg daily, itraconazole 400 mg daily, and clarithromycin, a single dose of 2.5 mg LEVITRA should not be exceeded in a 24-hour period.

For ketoconazole 200 mg daily, itraconazole 200 mg daily, and erythromycin, a single dose of 5 mg LEVITRA should not be exceeded in a 24-hour period.

In those patients who are stable on alpha-blocker therapy, phosphodiesterase type 5 (PDE5) inhibitors should be initiated at the lowest recommended starting dose. Concomitant treatment should be initiated only if the patient is stable on his alpha-blocker therapy. Stepwise increase in alpha-blocker dose may be associated with further lowering of blood pressure in patients taking a phosphodiesterase (PDE5) inhibitor including vardenafil. In

those

Distributed by: GlaxoSmithKline Research Triangle Park NC 27709.

The following serious adverse reactions with the use of LEVITRA (vardenafil) are discussed elsewhere in the labeling: Cardiovascular Effects [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ] Priapism [see WARNINGS AND PRECAUTIONS ] Effects on Eye [see WARNINGS AND PRECAUTIONS ] Sudden Hearing Loss [see WARNINGS AND PRECAUTIONS ] QT Prolongation [see WARNINGS AND PRECAUTIONS ]

Clinical

LEVITRA was administered to over 4430 men (mean age 56, range 18-89 years; 81% White, 6% Black, 2% Asian, 2% Hispanic and 9% Other) during controlled and uncontrolled clinical trials worldwide.

Over 2200 patients were treated for 6 months or longer and 880 patients were treated for at least 1 year.

In placebo-controlled clinical trials, the discontinuation rate due to adverse events was 3.4% for LEVITRA compared to 1.1% for placebo.

When LEVITRA was taken as recommended in placebo-controlled clinical trials, the following adverse reactions were reported (see Table 1). Table 1: Adverse Reactions Reported By ?2% of Patients Treated with LEVITRA and More Frequent on Drug than Placebo in Fixed and Flexible a Dose Randomized, Controlled Trials of 5 mg, 10 mg, or 20 mg Vardenafil Adverse Reaction Percentage of Patients Reporting Reactions Placebo N = 1199 LEVITRA N = 2203 Headache 4% 15% Flushing 1% 11% Rhinitis 3% 9% Dyspepsia 1% 4% Accidental Injury b 2% 3% Sinusitis 1% 3% Flu Syndrome 2% 3% Dizziness 1% 2% Increased Creatine Kinase 1% 2% Nausea 1% 2% a) Flexible dose studies started all patients at LEVITRA 10 mg and allowed decrease in dose to 5 mg or increase in dose to 20 mg based on side effects and efficacy.

b) All the events listed in the above table were deemed to be adverse drug reactions with the exception of accidental injury.

Back pain was reported in 2.0% of patients treated with LEVITRA and 1.7% of patients on placebo. Placebo-controlled trials suggested a dose effect in the incidence of some adverse reactions (headache, flushing, dyspepsia, nausea, and rhinitis) over the 5 mg, 10 mg, and 20 mg doses of LEVITRA.

LEVITRA film-coated tablets and vardenafil orally disintegrating tablets have been administered to over 17,000 men (mean age 54.5, range 18.89 years; 70% White, 5% Black, 13% Asian, 4% Hispanic and 8% Other) during

controlled

Potential For Pharmacodynamic Interactions With LEVITRA. Concomitant use of LEVITRA and nitrates and nitric oxide donors is contraindicated.

The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours after vardenafil were potentiated by a 20 mg dose of LEVITRA in healthy middle-aged subjects.

These effects were not observed when LEVITRA 20 mg was taken 24 hours before the nitroglycerin (NTG).

Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of LEVITRA and nitrates is contraindicated [ CONTRAINDICATIONS and CLINICAL PHARMACOLOGY ]. Caution is advised when PDE5 inhibitors are co-administered with alpha-blockers. PDE5 inhibitors, including LEVITRA and alpha-adrenergic blocking agents are both vasodilators with blood-pressure-lowering effects. When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. Clinical pharmacology studies have been conducted with co-administration of vardenafil with alfuzosin, terazosin or tamsulosin. [See DOSAGE AND ADMINISTRATION , WARNINGS AND PRECAUTIONS and CLINICAL PHARMACOLOGY .] Antihypertensives. LEVITRA may add to the blood pressure lowering effects of antihypertensive agents.

In a clinical pharmacology study of patients with erectile dysfunction, single doses of vardenafil 20 mg caused a mean maximum decrease in supine blood pressure of 7 mmHg systolic and 8 mmHg diastolic (compared to placebo), accompanied by a mean maximum increase of heart rate of 4 beats per minute. The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing.

Following multiple dosing for 31 days, similar blood pressure responses were observed on Day 31 as on Day 1.

LEVITRA (20 mg) did not potentiate the hypotensive effects of alcohol during the 4-hour observation period in healthy volunteers when administered with alcohol (0.5 g/kg body weight, approximately 40 mL of absolute alcohol in a 70 kg person). Alcohol and vardenafil plasma levels were not altered when dosed simultaneously. Studies in human liver microsomes showed that vardenafil is metabolized primarily by cytochrome P450 (CYP) isoforms 3A4/5, and to a lesser degree by CYP2C9. Therefore, inhibitors of these enzymes are expected to reduce vardenafil clearance [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS ]. Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in maximum concentration (Cmax) when co-administered with LEVITRA (5 mg) in healthy volunteers. A 5-mg LEVITRA dose should not be exceeded in a 24-hour period when used in combination with 200 mg once daily ketoconazole.

Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of LEVITRA should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily.

[See DOSAGE

AND

It is recommended not to exceed a single 2.5 mg LEVITRA dose in a 24-hour period when used in combination with indinavir. [See DOSAGE AND ADMINISTRATION and WARNINGS generic viagra soft tabs 100mg AND PRECAUTIONS .] Ritonavir (600 mg b.i.d.) co-administered with LEVITRA 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13fold increase in vardenafil Cmax.

The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a HIV protease inhibitor and a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9.

Ritonavir significantly prolonged the half-life of vardenafil to 26 hours. Consequently, it is recommended not to exceed a single 2.5 mg LEVITRA dose in a 72-hour period when used in combination with ritonavir. [See DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS .].

Erythromycin (500 mg t.i.d.) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax when co-administered with LEVITRA 5 mg in healthy volunteers. It is recommended not to exceed a single 5 mg dose of LEVITRA in a 24-hour period when used in combination with erythromycin. [See DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS ] Although specific interactions have not been studied, other CYP3A4 inhibitors, including grapefruit juice would likely increase vardenafil exposure.

No pharmacokinetic interactions were observed between vardenafil and the following drugs: glyburide, warfarin, digoxin, an antacid based on magnesium-aluminum hydroxide, and ranitidine.

In the warfarin study, vardenafil had no effect on the prothrombin time or other pharmacodynamic parameters.

Cimetidine (400 mg b.i.d.) had no effect on vardenafil bioavailability (AUC) and maximum concentration (Cmax) of vardenafil when co-administered with 20 mg LEVITRA in healthy volunteers. Vardenafil and its metabolites had no effect on CYP1A2, 2A6, and 2E1 (Ki >100 micromolar). Weak inhibitory effects toward other isoforms (CYP2C8, 2C9, 2C19, 2D6, 3A4) were found, but Ki values were in excess of plasma concentrations achieved following dosing. The most potent inhibitory activity was observed for vardenafil metabolite M1, which had a Ki of 1.4 micromolar toward CYP3A4, which is about 20 times higher than the M1 Cmax values after an 80 mg vardenafil dose. Vardenafil 20 mg, when co-administered with slow-release nifedipine 30 mg or 60 mg once daily, did not affect the AUC or Cmax of nifedipine, a drug that is metabolized via CYP3A4.

Nifedipine did not alter the plasma levels of LEVITRA when taken in combination.