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I'm in very good condition but was experiencing less than perfect erections.

I typically cut a 100mg pill into 4 pieces and take a 25mg piece.

For example, eat a normal lunch, come home from work at 5pm, take Viagra just before eating dinner - works for the rest of the evening.

For the absolute fastest results, for a little Saturday morning fun, take it right after waking up, wait 15 minutes (time to drink some coffee), and have at it. Vardenafil and tadalafil options for erectile dysfunction.

Arnold, MD Associate professor of psychiatry Director, Women’s Health Research Program University of Cincinnati College of Medicine Cincinnati, OH. Two new PDE-5 inhibitors have demonstrated efficacy and tolerability in clinical trials.

Overview of phosphodiesterase 5 inhibition in erectile dysfunction.

Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil—review of the literature. Cialis (IC351) provides prompt response and extended period of responsiveness for the treatment of men with erectile dysfunction (ED). Earliest time of onset of erections with vardenafil determined in an at-home setting. Chicago, IL: American Urological Association annual meeting, 2003. Minimal time to successful intercourse after sildenafil citrate: results of a randomized, double-blind, placebo-controlled trial. The efficacy and tolerability of vardenafil, a new selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical

trial

.

Vardenafil for treatment of men with erectile dysfunction: efficacy and safety in a randomized, double-blind, placebo-controlled trial. Vardenafil, a highly selective PDE5 inhibitor, improves erectile function in patients with diabetes mellitus. Efficacy and tolerability of vardenafil in men with erectile dysfunction following radical prostatectomy. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. Effects of tadalafil on erectile dysfunction in men with diabetes.

Efficacy and tolerability of tadalafil, a novel phosphodiesterase 5 inhibitor, in treatment of erectile dysfunction.

Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton Consensus Panel. Sildenafil has revolutionized management of erectile dysfunction (ED) over the past 5 years.

The FDA recently approved two additional medications, vardenafil and tadalafil, for treating ED. Like sildenafil, vardenafil and tadalafil are selective inhibitors of the phosphodiesterase (PDE) isoenzyme PDE-5, which is predominantly responsible for degrading cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum.

During sexual stimulation, nitric oxide is released from cavernous nerves and endothelial cells and activates the enzyme generic prescription viagra without guanylate cyclase, resulting in increased cGMP synthesis.

The cGMP triggers relaxation of smooth muscles, allowing increased blood flow into the penis and expansion of sinusoidal spaces; this prevents venous blood outflow and results in erection.

The PDE-5 inhibitors can potentiate erections by enhancing and prolonging the smooth musclerelaxant effects of the nitric oxide-cGMP cascade in the corpus cavernosum. 1 PDE-5 inhibitors have no effect without sexual stimulation.

Sildenafil 100 mg Vardenafil 20 mg

Tadalafil

20 mg Maximum concentration 450 ng/mL 20.9 ng/mL 378 ng/mL Time to maximum concentration 1.0 hour 0.7 hours 2.0 hours Half-life 4 hours 3.9 hours 17.5 hours Source: References 2 and 3.

Although the three PDE-5 inhibitors have similar mechanisms of action, their

selectivity

differs for PDE-5 compared with the PDE-6 and PDE-11 isoenzymes.

Sildenafil and vardenafil have lower selectivity than tadalafil for PDE-5 over PDE-6, which plays a role in phototransduction, the process by which light impulses are converted into nerve impulses in the retina.

Thus, tadalafil is less likely than the other agents to cause visual disturbances such as abnormal color vision, increased brightness of light, or mild haziness.

Tadalafil shows lower

selectivity

than sildenafil or vardenafil for PDE-5 over PDE-11, meaning that tadalafil inhibits PDE-11 at clinical doses.

PDE-11 is found in various tissues, but its physiologic significance and consequences of its inhibition are unknown.

Vardenafil, tadalafil, and sildenafil have different pharmacokinetic characteristics ( Table 1 ). A lower starting dosage is required with vardenafil than with sildenafil because of the former agent’s greater in vitro and in vivo potency, but whether this results in greater clinical efficacy or tolerability is unknown.

Vardenafil and sildenafil reach maximum plasma concentration within 30 minutes to 2 hours (median 1 hour for sildenafil and 0.7 hour for vardenafil). By contrast, tadalafil reaches maximum concentration within 30 minutes to 6 hours (median 2 hours).

However, studies of time to onset of

erection

indicate that about one-third of patients using the maximum recommended doses of any of these agents will experience onset within 14 to 16 minutes.

Absorption rates for sildenafil and vardenafil are reduced when they are taken with a high-fat meal. High-fat foods do not affect tadalafil’s absorption rate.

Drug brand name: Levitra Class: Phosphodiesterase-5 inhibitor FDA-approved indication: Erectile dysfunction Approval date: August 19, 2003 Manufacturer: Bayer Corp. (distributed by GlaxoSmithKline) Dosing forms: 2.5 mg, 5 mg, 10 mg, 20 mg Dosing recommendations: Start at 10 mg about 1 hour before sexual activity. Maximum recommended

dose

is 20 mg; maximum dosing frequency is once per day.

Consider 5-mg starting dose for patients age 65 and older.

Because of its 17.5-hour half-life, tadalafil has a longer period of activity than the other PDE-5 inhibitors.

Most patients can complete sexual intercourse up to 36 hours after taking tadalafil, which potentially allows spontaneous sexual activity. Sildenafil and vardenafil each are effective for about 4 hours. All three PDE-5 inhibitors are eliminated by hepatic metabolism, mainly by the CYP 3A4 hepatic enzyme. Therefore, concomitant use with CYP 3A4 inhibitors—such as ketoconazole, ritonavir, grapefruit juice, or erythromycin —results in increased plasma levels of these agents, and the use of CYP 3A4 inducers such as rifampin reduces plasma levels of the concomitant agent. Drug brand name: Cialis Class: Phosphodiesterase-5 inhibitor FDA-approved indication: Erectile dysfunction Approval date: November 21, 2003 Manufacturer: Eli Lilly and Co. Dosing forms: 5 mg, 10 mg, 20 mg Dosing recommendations: Start at 10 mg before anticipated sexual activity. Maximum recommended dose is 20 mg; maximum dosing frequency is once per day.

In a placebo-controlled, 12-week trial, 7 601 men with mildly to severely impaired erectile function received placebo or 5, 10, or 20 mg of vardenafil. Subjects receiving vardenafil at any dose saw significantly greater improvement in erectile function than did the placebo group. Percentage of successful intercourse ranged between 71% and 74% for the three vardenafil doses.

For the 20-mg dose, 80% of patients experienced improved erections compared with 30% of those taking placebo.

In another trial of 805 men with mild to severe ED, 8 vardenafil in 5-mg, 10-mg, and 20-mg doses demonstrated efficacy versus placebo. Eighty-five percent of men using vardenafil, 20 mg, reported improved erections at 26 weeks compared with 28% in the placebo group.

Comparison of

clinical

trials with sildenafil, vardenafil and tadalafil in

erectile

dysfunction.

1 The University of Queensland, School of Biomedical Sciences, Australia. Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction. Search in PubMed Search in NLM Catalog Add to Search. 1 The University of Queensland, School of Biomedical Sciences, Australia.

Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age.

In the first major trial of sildenafil in ED, at 24 weeks, improved erections were reported by 77 and 84% of

men

taking sildenafil 50 and 100mg, respectively.

Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED.

Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication). The most commonly reported adverse effects with sildenafil are headache, flushing and dyspepsia. Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED. The only advantage that vardenafil has over sildenafil is that it does not

inhibit

phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil.

Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action.

Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.

Levitra (vardenafil hydrochloride) and Viagra (sildenafil)

are

erectile dysfunction drugs that work by blocking a certain enzyme (phosphodiesterase-PDE5) used to treat erectile dysfunction (impotence). headache, flushing (warmth or redness in your face, neck, or chest), runny or stuffy nose, stomach upset, heartburn, dizziness, back pain, or nausea. Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.

Common side effects of Viagra include: warmth or redness in the face, neck, or chest, stuffy nose, headaches, stomach pain, upset stomach, nausea, diarrhea, memory problems, back pain, an inability to differentiate between the colors green and blue, loss of hearing, ringing in the ears, and dizziness. Levitra is a prescription medicine taken by mouth for the treatment of erectile dysfunction (ED) in men.

ED is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. A man who has

trouble

getting or keeping an erection should see his doctor for help if the condition bothers him.

Levitra may help a

man

with ED get and keep an erection when he is sexually excited.

Viagra is a prescription medicine used to treat erectile dysfunction (ED).

You will not get an erection just by taking this medicine. Viagra helps a man with erectile dysfunction get and keep an erection only when he is sexually excited (stimulated).

It is not known if Viagra is safe and effective in women or children under 18 years of age. Levitra may interact with other medications for erectile dysfunction, conivaptan, imatinib, isoniazid, antidepressants, antibiotics, antifungals, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, or HIV/AIDS medicines. Viagra may interact with other medications for erectile dysfunction,

conivaptan

, imatinib, isoniazid, antidepressants, antibiotics, antifungals, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, or HIV/AIDS medicines.

Some men can only take a low dose of Levitra because of medical conditions or medicines they take. Your doctor will prescribe the

dose

that is right for you.

If you are older than 65 or have liver problems, your doctor may start you on a lower dose of Levitra.

If you have prostate problems or high blood pressure, for which you take medicines called alpha-blockers, your doctor may start you on a lower dose of Levitra.

If you are taking certain other medicines your doctor may prescribe a lower starting dose and limit you to one dose of Levitra in a 72-hour (3 days) period.

Take 1 Levitra tablet about 1 hour (60 minutes) before sexual activity. Some form of sexual stimulation is needed for an erection to happen with Levitra. Do not change your dose of Levitra without talking to your doctor. Your doctor may lower your dose or raise your dose, depending on how your body reacts to Levitra.

Call your doctor or emergency room immediately if you accidentally took more Levitra than prescribed. Take Viagra exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much Viagra to take and when to take it.

Your healthcare provider may change your dose if needed.

You may take Viagra

between

30 minutes to 4 hours before sexual activity if needed. If you take Viagra after a high fat meal (such as a cheeseburger and french fries), Viagra may take a little longer to start working Do not take Viagra more than 1 time a day. If you accidentally take too much Viagra, call your

doctor

or go to the nearest hospital emergency room right away.

View

side-by-side comparisons of medication uses, ratings, cost, side effects, interactions

and

more. Levitra Remove Levitra from your drug comparison Staxyn Remove Staxyn from your drug comparison. Levitra may also be used for purposes not listed in this medication guide.

Levitra may also be used for purposes not listed in this medication guide.

Staxyn may also be used for purposes not listed in this medication guide.

Staxyn may also be used for purposes not listed in this medication guide. Cialis Viagra Sildenafil Tadalafil Caverject Impulse Vardenafil Alprostadil Edex Stendra Caverject Muse Avanafil. For Erectile Dysfunction: It works for us guys over 60! For Erectile Dysfunction: I'm 68 and have been using Levitra 20 mg for several years. It works great for me and wife with little side effects.

I purchase this medication from Global Pharmacy in Canada. The cost is about $3.62 when paying by check and takes 2 weeks to receive your order in the mail.

For Erectile Dysfunction: 47 years old healthy, heavily involved in exercising, a sex maniac all my life but started having performance problems 2 years ago.

I enjoy long foreplays to get my woman ready for the big thing but as I aged I found

harder

to stay hard that long so by the time intercourse was due I was not stiff enough. With Staxyn I am ready in 30-40 minutes and I can stay hard for hours as long as I am engaged in sexual activity. Except a slight upset stomach no other side effects so far.

For Erectile Dysfunction: I'm 57 years old and I've been a diabetic for over 20 years and it has gotten harder to maintain an erection. I tried Staxyn a few nights ago and was very happy with the

results

. For me it worked better than Viagra, Cialis and I've even tried injectables.

I am often asked which is the best of the three most common erectile dysfunction treatments: Viagra, Levitra or Cialis.

There is no simple answer to this question, as some men find one treatment works better for them than the others.

However

there

are some interesting differences… What is Viagra? Viagra is the most well-known of the three as it has been around for over 15 years. This means that a lot is known about its effects and side effects.

It works within an hour of taking a tablet, and is best taken on an empty stomach.

The effects of Viagra will last for four to six hours.

Viagra was developed and originally marketed by the pharmaceutical company Pfizer, and until 2013 Pfizer was the only company allowed to sell it.

When Pfizer’s patent on Viagra expired, the market was open for other companies to produce the medicine, albeit under its generic name Sildenafil, rather than the brand name Viagra.

Sildenafil contains exactly the same active ingredient as Viagra (

sildenafil

citrate), and works in the same way.

However, because it is the generic version of the medicine, rather than the brand, Sildenafil is considerably cheaper.

Levitra will last for a similar amount of time as Viagra (four to six hours).

The main difference to Viagra is that Levitra tends to be less affected by food or alcohol so can be taken with

meals

.

There is also some evidence that Levitra is more effective in diabetics than other erectile dysfunction medicines. The effects of Cialis (tadalafil) last much longer than those for Viagra or Levitra (up to 36 hours) so many men prefer it as involves less planning. The downside is that if you do experience side effects these can last for longer too.

Like Levitra, Cialis is not affected much by food, so can be taken after a meal.

Different erectile dysfunction medicines suit different people, but it is difficult to tell which one will be best for you until you have tried them all. While a particular erectile dysfunction medicine may not work for you first time round, we recommend taking it at least eight times before giving up and trying another.

This is because it can often take this long to determine whether or not a medicine is right for you.

We also often suggest that men initially try all three erectile dysfunction medicines to see which is best for them, and we offer a viagra online prescription free starter pack of Viagra, Levitra and Cialis for those suitable. You can Viagra, Cialis and Levitra safely online through LloydsPharmacy’s

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If appropriate, our London based GPs can prescribe you treatment for erectile dysfunction with Same-Day Collection, as well as Next-Day or FREE Standard Delivery.

If you’re unsure which ED treatment will be best for you then take our free ED assessment and our doctors will help you decide: How effective are Viagra, Cialis and Levitra?

Viagra, Cialis and Levitra have all been shown to be effective in 60-70% of men with erectile dysfunction . However, as above, it is possible that one medicine will be more or less effective than the others, and therefore it is best to initially try out all three to see which is best. What are the side effects of Viagra, Cialis and Levitra?

All three have similar side effects – headaches, stuffy nose, facial flushing, stomach ache or back pain being the most common.

Some men who have had bad side effects with, say, Viagra will have fewer with Levitra or Cialis, but similarly some find the prolonged side effects of Cialis troubling.

Viagra, Cialis and Levitra should not be taken by men who take medicines or recreational drugs containing nitrates.

Cialis should not be taken by men who are on medicines called alpha blockers which are sometimes used to treat prostate problems or high blood pressure. Men who take alpha blockers can use Viagra or Levitra but must allow at least a six hour gap between taking the alpha blocker and Viagra or Levitra. Viagra, Levitra and Cialis all work in a similar way. They all relax the blood vessels which supply blood to the penis, meaning that more blood can get there when aroused. These medicines are not aphrodisiacs, so you will still need to be sexually stimulated in order to

get

an erection. Sildenafil and Spedra are two other major erectile dysfunction medicines which work in a similar way to Viagra, Cialis and Levitra.

As outlined above, Sildenafil is the generic version of Viagra, and contains the same active ingredient. Out of the five, Spedra is the newest medicine on the market, and takes the shortest amount of time to work – just 15 minutes in some men. If your ED has a psychological cause, such as stress, anxiety or depression, counselling can be an effective treatment.



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