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Men who take Cardura, Flomax, or Hytrin for urinary symptoms should not take vardenafil.

This medication can affect how other medications work.

Be sure your provider and pharmacist know

all

This medication should not be stored in a pillbox since it should only be taken prior to sexual activity. Ask your care team where to return any unused medication for disposal.

Do not flush down the toilet or throw in the trash.

Vardenafil is available through most retail pharmacies.

This medication may be covered under your prescription drug plan.

Patient assistance may be available to qualifying

individuals

Your care team can help you find these resources, if they are available.

There are a few side effects experienced with vardenafil. Talk to your care team if you have concerns about these side effects. Do not take a higher dose of vardenafil than your provider orders for you.

Headache, facial flushing, stuffy or runny nose, and upset stomach can occur.

Less frequent side effects include blurry vision, a bluish hue to the field of vision, difficulty telling the difference between the colors blue and green, a sensitivity to light, or a sudden loss of vision or hearing. If you experience any of the following while using vardenafil, seek immediate medical attention: An erection lasting more than 4 hours. Chest, arm or neck pain, or nausea during sexual activity.

Remember, vardenafil does not protect against sexually transmitted diseases, nor does it prevent pregnancy. Effective birth control is recommended during cancer treatment.

Even if you are not producing sperm, you

could

It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum.

The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection.

The

The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase

type

BAY 389456 BAY-389456 BAY38-9456 DE 19750085 1997 WO 99/24433 1999.

Associated Conditions Erectile Dysfunction Contraindications & Blackbox Warnings.

Learn about our commercial Contraindications & Blackbox Warnings data. Vardenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH).

Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection.

Vardenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum.

This means that, with vardenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, vardenafil should not cause an erection.

Vardenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells.

Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by vardenafil enhances erectile function by increasing the amount of cGMP. Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%.

Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. M1 shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose). Symptoms of overdose include vision changes and back and muscle pain.

Affected organisms Humans and other mammals Pathways Not Available Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" href="javascript:void(0);"> Levitra. Levitra® is a type of medication known as a PDE5 inhibitor that is used to treat erectile dysfunction. It comes in several different doses and is taken as-needed.

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

Levitra® functions similarly to Viagra®, however it comes in different doses, has an increased risk of a change seen on EKG known as QT prolongation (which can lead to irregular heartbeats, which can be dangerous), and has a decreased risk of causing the bluish visual tint that is sometimes experienced by Viagra® users.

For erectile dysfunction, Levitra® should be taken without food at least 30-60 minutes before sex and its effects last up to 8 hours. Serious side effects include an erection lasting more than 4 hours, sudden vision loss in one or both eyes, and sudden hearing decrease or loss. If these occur, seek medical attention immediately. Talk to your doctor about your viagra no prescription usa medical conditions and your medications before taking Levitra®.

Do not take Levitra® if you are allergic to its ingredients or if you are already taking nitrates (such as nitroglycerin), street drugs called “poppers” (such as amyl nitrate, amyl nitrite, butyl nitrate), or guanylate cyclase stimulators (such as riociguat).

Levitra® is a drug that is used to treat erectile dysfunction (ED). It comes in four doses, 2.5 mg, 5 mg, 10 mg and 20 mg. The 10 mg dose is the most common starting dose, although some people may benefit from higher or lower doses. Levitra® is part of a “family” of medicines used to treat ED called phosphodiesterase-5 inhibitors (PDE5i).

Other drugs in this family include Cialis (tadalafil), Viagra (sildenafil), and Stendra (avanafil).

All of these drugs have the same mechanism of action, but there are subtle differences that may cause your doctor to recommend one drug out of the others based on your preferences and treatment goals.

Levitra® is a short acting drug with an average half-life of 4–5 hours, which means that half the medicine is gone from the body after 4–5 hours in healthy people.

The time that it takes to eliminate Levitra® may be prolonged in older people and people with liver or kidney disease meaning the drug may work longer in these people. Levitra® functions very similarly to Viagra® with a few key differences.

Levitra® comes in doses of 2.5 mg, 5 mg, 10 mg and 20 mg, while Viagra® comes in 25 mg, 50 mg, and 100 mg doses. The most common starting dose for Viagra® is 50 mg, and the most common dose for Levitra® is 10 mg. The use erection pills without prescription of Levitra® increases the likelihood of QT prolongation (a change seen on an EKG), which can sometimes be followed by irregular heartbeats. In rare cases, QT prolongation can cause dangerous abnormal heart rhythms that can even be fatal.

Also, Levitra® does not cause the bluish visual tint sometimes caused by Viagra®.

This is because unlike Viagra®, Levitra® does not inhibit PDE6, which is found in the retina and can cause visual color changes when blocked or inhibited. It’s also important to note that side effects are very individual, and someone who has side effects with one drug may not have them with the other. Talk to your doctor about the risks and possible side effects before you begin taking Levitra or Viagra. Some people think that higher is always better when it comes to ED medication and erection pills without prescription may even take more than the highest FDA-approved dose of Levitra®, which is 20 mg.

Levitra® has been studied in doses higher than 20 mg, including 40 mg twice daily. The reason the maximum FDA-approved dose of Levitra® is 20 mg is because above that dosage there is very little increase in benefit with a much higher risk of side effects.