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Simultaneous use of bosentan and sildenafil may result in increased bosentan blood levels and decreased sildenafil blood levels. It is not known if these changes are clinically significant. Although a drug interaction has been demonstrated with sildenafil and bosentan, dose adjustments are presently not recommended for either drug. Patients with human immunodeficiency virus (HIV or AIDS) who are taking medicines called antiretroviral agents should not use a phosphodiesterase inhibitor such as sildenafil since it can dramatically impair the efficacy of the antiretroviral.

Use of sildenafil with epoprostenol may reduce the blood level of sildenafil.

Use of sildenafil with beta blockers (another type of heart or blood pressure medicine) may increase the levels of sildenafil. Miscellaneous considerations: Is there cheap viagra without prescription any risk of blindness when using sildenafil?

There have been rare reports of blindness with use of all the currently available PDE5 inhibitors, including sildenafil. This type of blindness, which may be permanent, is called non-arteritic anterior ischemic optic neuropathy (NAION). It is not yet clear whether this is related to the use of sildenafil or to the underlying cardiovascular diseases that place the persons at risk for this particular type of blindness, even in the absence of sildenafil use. There is no research to determine whether use of sildenafil is beneficial or safe in patients with retinitis pigmentosa, and use in these patients is not recommended. As noted above, patients taking sildenafil should seek immediate medical attention in the event of sudden vision loss. Yes, studies have evaluated sildenafil in both men and women with PAH, and no differences in side effects have been reported between genders.

Studies have not shown any effect on sexual function in women who have taken sildenafil.

Viagra is now being used to treat not only erectile dysfunction (ED) but also pulmonary hypertension. And the drug may have potential for treating several other conditions, according to a recent report.

The three ED medications currently on the market—Viagra, Levitra, and Cialis—all work by the same means, and they have similar side effects. The most common are headaches and facial flushing, which occur in 15% of men. Other reactions include nasal congestion, indigestion, and back pain. The most important worry about ED pills is their ability to widen arteries enough to lower blood pressure.

And men who are taking nitrates should never use any of the ED pills. Although some of the drugs’ side effects may be troublesome, others may be helpful, and scientists are studying whether ED pills might help treat a variety of nonsexual problems.

Viagra (sildenafil) has been on the market longest and is most studied.

It’s yet not clear if the other ED pills offer similar benefits, but Viagra, at least, may prove useful for some other conditions, including these: Pulmonary hypertension.

Viagra is now marketed under the name Revatio for this uncommon but serious disorder of high pressure in the blood vessels leading to the lungs.

Viagra can reduce pulmonary artery pressure at high altitude and improve the ability to exercise in low oxygen conditions. In affected individuals, exposure to the cold triggers spasm of the small arteries that supply blood to the fingers, toes, or both, which become pale, cold, and painful. Both Viagra and Levitra have been helpful in clinical trials. Studies suggest Viagra might help patients with congestive heart failure or diastolic dysfunction. Further details are published in the August 2007 issue of Harvard Men’s Health Watch.

April 28, 2003 -- A new study has found that the impotence drug Viagra could ramp up the sex lives of women who take it, just as it has done for men. The 12-week study focused on 202 post-menopausal or post-hysterectomy women who complained of female sexual arousal disorder.

The women in the group who took Sildenafil — the little blue pill commonly known as Viagra — took notes after each sexual experience, and reported better overall sexual satisfaction compared with those who took a placebo. Their enhanced sex lives included better arousal, lubrication and orgasm.

The study was conducted by Laura Berman, director of the Berman Center and a professor of OB-GYN and psychiatry at Northwestern University in Chicago, and Dr. Jennifer Berman, director of the Female Sexual Medicine Center at UCLA Medical Center in Los Angeles.

The researchers say that the results are preliminary.

"In terms of ability to achieve orgasm, there was a statistically significant movement," Laura Berman said on ABCNEWS' Good Morning America.

"It increases blood flow to the genital area, increases the sensation of warmth, tingling and fullness," she said.

More than 50 million women experience some type of sexual dysfunction.

Jennifer Berman said it's important for women to remember that this pill can't overcome mental and emotional barriers to a satisfying sex life. "At this point, we can say that women with significant emotional or relationship problems cheap viagra without prescription and women that have desire problems related to their interest in being sexual might not be the best candidates," Jennifer Berman said.

"It's for women who were satisfied with their sexual response at one point and now, for whatever medical reason, are no longer able to respond," she said.

Women who suffer from female sexual arousal disorder can experience a variety of symptoms, including lack of "excitement," vaginal dryness, loss of sensation and sensitivity in the genitals and nipples and low blood flow to the genitals. Women in the study were screened to make sure that psychological or relationship issues were not the cause of the problem. Since Viagra enhances sexual arousal in men by increasing the blood flow to the penis, the Bermans theorized that the drug could have a similar effect on women, increasing the blood flow to the female genitals and thereby producing better arousal, sensation and lubrication in the genital area. Women in the study were given doses of 50 milligrams, which was increased to 100 milligrams only once during the study based on how well the lower dose was working, and the women's tolerance to it. The pill was to be taken prior to sexual activity but no more than once daily. Each patient had to engage in sexual activity at least once a week and keep a personal log about it. During the course of the study, neither the patients nor the doctors knew which patients were receiving the Viagra. Women taking Viagra reported mild to moderate side effects, including headache, flushing, nausea, and vision symptoms — the same side effects reported by men who take the drug. Effect of Regular Sildenafil on Blood Pressure and Arterial Function in Hypertension. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U.S.

Study Details Tabular View No Results Posted Disclaimer How to Read a Study Record.

Condition or disease Intervention/treatment Phase Hypertension Drug: Sildenafil citrate Phase 2.

Inhibitors of phosphodiesterase type 5 (PDE5), such as sildenafil, relax blood vessels. In the penis this facilitates erection and sildenafil has proved a very effective treatment for male erectile dysfunction. To date, most work on the effects of sildenafil on blood pressure have mainly been investigated in single dose studies.

These have shown that sildenafil causes a modest reduction in blood pressure, even when taken with other blood pressure-lowering drugs, providing reassurance on safety when taken as a single dose for erectile dysfunction.

However, these studies do not offer any insight into the potential of PDE5 inhibition in the long-term treatment of hypertension. We will address this question by investigating the effects of regular administration of sildenafil on blood pressure. It may also be postulated that, because of its mechanism of action, sildenafil will also improve the function of the endothelium, the single layer of cells that lines all blood vessels. Therefore, the effect of regular sildenafil on endothelial function in hypertension will also be investigated in the study.

The study will be performed in a randomised, placebo-controlled, double blind, 2-way crossover manner.

Sildenafil and matched placebo will each will taken three times daily for 2 weeks, with a washout of at least 6 days between treatments. Measurements will be made acutely (before and 1 hour after oral sildenafil) of heart cheap viagra without prescription rate, blood pressure, pulse wave analysis (a measure of wave reflection in arteries), pulse wave velocity (a measure of arterial stiffness) and flow-mediated dilatation (a measure of endothelial function). These measurements will be repeated 2 weeks later (again just before and 1 hour after oral sildenafil). In addition, ambulatory blood pressure will be recorded after 2 weeks of treatment (baseline ambulatory BP will be taken as the recording made at diagnosis). Older men like Playboy’s Hugh Hefner and actor Michael Douglas have sung the praises of Viagra, but now scientists say the erectile dysfunction pill is not only good for your sex life — it’s good for your heart. In the bedroom, Viagra allows greater blood flow to the penis.

But in the heart, the “little blue pill” can prevent heart muscle thickening and early-stage heart failure, according to research published today in the open access journal BMC Medicine. "Large clinical trials are now urgently needed to build on these encouraging findings,” said lead author Dr. Isidori, associate professor of endocrinology at Sapienza University of Rome.

Dosages used for heart ailments are lower than those used for erectile dysfunction, and patients in the study showed few side effects. “Surprisingly, in over 1600 treated subjects, no increased risk of visual disturbance, photosensitivity and ‘blue haze,’ was observed,” he told NBC News. The active ingredient in Viagra is sildenafil citrate, which is a phosphodiesterase type 5 inhibitor (PDE5i). The inhibitor cheap viagra without prescription blocks the enzyme PDE5, which prevents relaxation of smooth muscle tissue. Researchers analyzed randomized trials that had been published between January 2004 and May 2014, choosing 24 involving mixed populations of patients who were treated with PDE5i or a placebo. PDE5i was given to men who had cardiovascular disorders, but who did not necessarily suffer from sexual impotence, according to Isidori. The study found that the inhibitor prevented the heart from changing shape in patients suffering from left ventricular hypertrophy, a condition that causes thickening and enlargement of the heart muscle.

The drug also improved functioning of the heart in patients with a variety of cardiac conditions, with no effect on blood pressure.

In fact, researchers found that the drug improved efficiency when the heart pumped blood into vessels, along with relaxation between beats. “Very few drugs used in cardiology can actually affect these parameters.

For this reason their implications in the treatment and prevention of heart failure are huge.” However, Isidori notes that because these studies were conducted exclusively on men, the next step should be a larger trial on women.

This site is protected by recaptcha Privacy Policy | Terms of Service. "A significant number of subjects suffering from erectile dysfunction are much happier to take pills for heart failure or high blood pressure than to improve their erections." “I am not surprised and it’s good news,” said Dr.

Kloner, professor of medicine in the cardiovascular division at the Keck School of Medicine at USC in California. “We can always use a new drug for heart failure." Kloner co-authored the book, “Viagra: How the Miracle Drug Happened & What It Can Do for You.” He said this is not the first time, scientists have looked to Viagra for potential heart benefits.

In 1989, British scientists tested sildenafil citrate as a medication to treat high blood pressure and angina. By the 1990s in early trials of the drug, researchers noticed an interesting side effect — an increase in erections.

In 1996, the pharmaceutical company Pfizer patented it as Viagra, and in just two years, doctors had ordered more

than

“When the drug first came out there was a big scare — is this going to kill people?” said Dr.

Kociol, director of the heart failure program at the CardioVascular Institute at Beth Israel Deaconess viagra for sale no prescription Medical Center in Boston.

“But in all studies, to the best of my knowledge, it’s not shown any increase in cardiac events in patients who take these drugs,” he said. Past studies have suggested Viagra and other PDE5 inhibitors may have benefits for heart failure by decreasing pulmonary artery resistance and providing cardio-protective effects in settings with low blood flow, according to Kociol. “They also improve exercise tolerance in patients with heart failure,” he said. The drug may even reduce the size of a heart attack. But Kociol said scientists have to “temper” their enthusiasm as more studies are necessary.

“As interesting as this paper is, there have been conflicting results,” he said. “If there is a silver bullet, it remains to be seen.” Kociol added that researchers also need to “pay more attention” differences between men and women and between racial groups.

Some earlier research suggests that drugs like Viagra might interact differently with estrogen, which is known to have naturally protective properties for the heart. Learn about our expanded patient care options for your health care needs. About Johns Hopkins Medicine Centers & Departments Patient Safety & Quality Maps & Directions News & Publications Commitment to Community For the Media Careers Contact Us Make a Gift Hopkins Medicine Home.

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Find a Faculty Director Apply for Admission Take CME Courses Apply to Graduate Medical Education Read Hopkins Medicine Magazine Make a Gift Submit a Kudos Announcement. VIAGRA BLUNTS EFFECTS OF STRESS ON THE HUMAN HEART.

Johns Hopkins Medicine Office of Corporate Communications Media contact: David March 410-955-1534; dmarch1@jhmi.edu October 24, 2005.

VIAGRA BLUNTS EFFECTS OF STRESS ON THE HUMAN HEART.

Sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, reduces the stimulatory effects of hormonal stress on the heart by half, according to results of a new study by researchers at Johns Hopkins. While sildenafil is more widely known for helping genital blood vessels expand to maintain an erection and, more recently, as a treatment for pulmonary hypertension, it has been thought to have little direct effect on the human heart.

In the heart, sildenafil blunts the strengthened heartbeat caused by chemically induced stress, thereby lessening the excess amount of blood and force used to pump it to the body, according to study senior author and cardiologist David Kass, M.D., a professor at The Johns Hopkins University School of Medicine and its Heart Institute.

“Sildenafil effectively puts a ‘brake’ on chemical stimulation of the heart,” says Kass. The researchers’ findings, which appear in the journal Circulation online Oct.

24, are believed to be the first confirmation in humans that sildenafil has a direct effect on the heart.

Previous research by Kass and his team showed that sildenafil had such effects in mice, blocking the short-term effects of hormonal stress in the heart. Related studies by the group also showed that sildenafil prevents and reverses the long-term effects in the heart from chronic high blood pressure. Moreover, Kass adds, the latest Hopkins results confirm that sildenafil helps control heart function only when the heart is under duress, but has little impact under normal conditions. Separate research from Kass and his team published earlier this year in the journal Nature Medicine showed that, in mice, sildenafil could reverse the negative effects on heart muscle weakened by heart failure and enlargement, a condition called hypertrophy.

“But we had no firm evidence as to whether or how this therapy might work in the human heart.

Our latest research provides firm evidence this drug does indeed have an important impact on the heart.” Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month study.

Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength.

Between injections, study participants were randomly assigned to a group that was treated with sildenafil (100

milligrams

All participants were then given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection.

This included blood pressure readings, electrocardiograms and echocardiograms, as well as blood samples to confirm relatively equal levels of sildenafil and other enzymes.

Results showed that each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body.

“This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure,” adds Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups.