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Bedaquiline has been reported to prolong the QT interval.

Prior to initiating bedaquiline, obtain serum electrolyte concentrations and a baseline ECG. An ECG should also be performed at least 2, 12, and 24 weeks after starting bedaquiline therapy.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil also produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

Bepridil: (Severe) Concomitant administration of bepridil and vardenafil may cause additive QT prolongation and an increased risk of torsades de pointes (TdP). Bismuth Subcitrate Potassium; Metronidazole; Tetracycline: (Moderate) Consider the potential for additive QT effects if vardenafil is administered with metronidazole. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Potential QT prolongation has been reported in limited case reports with metronidazole.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval. Bismuth Subsalicylate; Metronidazole; Tetracycline: (Moderate) Consider the potential for additive QT effects if vardenafil is administered with metronidazole.

Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Potential QT prolongation has been reported in limited case reports with metronidazole. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.

Boceprevir: (Moderate) Close clinical monitoring is advised when administering vardenafil with boceprevir due to an increased potential for vardenafil-related adverse events, such as hypotension, syncope, visual disturbances, and priapism. During coadministration, do not exceed a maximum vardenafil dosage of 2.5 mg in 24 hours. If vardenafil dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment.

Predictions about the interaction can be made based on the metabolic pathways of vardenafil.

Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; boceprevir inhibits this isoenzyme. When used in combination, the plasma concentrations of vardenafil may be elevated.

Bosentan: (Minor) Vardenafil is metabolized by cytochrome P450 3A4.

It can be expected that concomitant administration of bosentan, a CYP3A4 enzyme-inducer, will decrease plasma levels of vardenafil, however, no interaction studies have been performed.

Brompheniramine; Carbetapentane; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor buy 10 viagra pills patients for decreased pressor effect if these agents are administered concomitantly. Buprenorphine: (Major) Buprenorphine should be used cautiously and with close monitoring with vardenafil.

Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes (TdP).

FDA-approved labeling for some buprenorphine products recommend avoiding use with Class 1A and Class III antiarrhythmic medications while other labels recommend avoiding use with any drug that has the potential to prolong the QT interval, such as vardenafil.

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive effect on the QT interval was observed.

If these drugs are used together, consider the potential for additive effects on the QT interval. Buprenorphine; Naloxone: (Major) Buprenorphine should be used cautiously and with close monitoring with vardenafil. Buprenorphine has been associated with QT prolongation and has a possible risk of torsade de pointes (TdP).

FDA-approved labeling for some buprenorphine products recommend avoiding use with Class 1A and Class III antiarrhythmic medications while other labels recommend avoiding use with any drug that has the potential to prolong the QT interval, such as vardenafil. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). When vardenafil (10 mg) was buy 10 viagra pills given with gatifloxacin (400 mg), an additive effect on the QT interval was observed.

If these drugs are used together, consider the potential for additive effects on the QT interval. Carbamazepine: (Minor) Vardenafil is metabolized by cytochrome P450 3A4. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, such as carbamazepine, will decrease plasma levels of vardenafil, however, no interaction studies have been performed. Carbetapentane; Chlorpheniramine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbetapentane; Diphenhydramine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbetapentane; Guaifenesin; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbetapentane; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbetapentane; Phenylephrine; Pyrilamine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Carbinoxamine; Hydrocodone; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Carbinoxamine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Ceritinib: (Major) Due to increased vardenafil exposure, do not use vardenafil orally disintegrating tablets with ceritinib. If possible, avoid concomitant use of vardenafil oral tablets with ceritinib due to the potential for prolongation of the QT interval and increased vardenafil exposure. If concomitant use of ceritinib and vardenafil oral tablets is unavoidable, decrease the vardenafil dosage and periodically monitor ECGs and electrolytes.

Vardenafil is a sensitive CYP3A4 substrate that can produce an increase in QTc interval at both therapeutic and supratherapeutic doses.

Ceritinib is a strong CYP3A4 inhibitor that has been reported to cause concentration-dependent QT prolongation.

Coadministration with another strong CYP3A4 inhibitor increased the AUC and Cmax of vardenafil in healthy volunteers by 10-fold and 4-fold, respectively. Chlophedianol; Guaifenesin; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Chloroquine: (Major) Chloroquine administration is associated with an increased risk of QT prolongation and torsades de pointes (TdP).

The need to coadminister chloroquine with drugs known to prolong the QT interval should be done with a careful assessment of risks versus benefits and should be avoided when possible. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with chloroquine include vardenafil. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly. Chlorpheniramine; Dihydrocodeine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors.

Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Chlorpheniramine; Hydrocodone; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly. Chlorpheniramine; Phenylephrine: (Moderate) The therapeutic effect of phenylephrine may be decreased in patients receiving phosphodiesterase inhibitors. Monitor patients for decreased pressor effect if these agents are administered concomitantly.

Chlorpromazine: (Major) Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). When vardenafil (10 mg) was given with gatifloxacin (400 mg), an additive effect on the QT interval was observed.

The effect of vardenafil on the QT interval should be considered when prescribing the drug. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include chlorpromazine. Phenothiazines have been associated with a risk of QT prolongation and/or torsade de pointes TdP. This risk is generally higher at elevated drugs concentrations of phenothiazines. Chlorpromazine is specifically associated with an established risk of QT prolongation and TdP; case reports have included patients receiving therapeutic doses of chlorpromazine. Agents that prolong the QT interval could lead to torsade de pointes when combined with a phenothiazine, and therefore are generally not recommended for combined use. Cimetidine: (Major) Phosphodiesterase inhibitors are metabolized principally by cytochrome P450 (CYP) 3A4 (major route) and 2C9 (minor route) isoenzymes.

Cimetidine is a known inhibitor of hepatic CYP enzymes.

Cimetidine (800 mg) caused a 56% increase in plasma sildenafil concentrations when coadministered with sildenafil 50 mg to healthy volunteers. Population data from patients in clinical trials also indicate a reduction in sildenafil clearance when it was coadministered with cimetidine. If possible, cimetidine use should be avoided in patients who take phosphodiesterase inhibitors Ciprofloxacin: (Moderate) Due to an increased risk for QT prolongation and torsade de pointes (TdP), caution is advised when administering ciprofloxacin with vardenafil.

Rare cases of QT prolongation and TdP have been reported with ciprofloxacin during postmarketing surveillance. Both therapeutic and supratherapeutic doses of vardenafil produce and increase in QTc interval.

Cisapride: (Severe) Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). The effect of vardenafil on the QT interval should be considered when prescribing the drug. Because of the potential for torsade de pointes (TdP), use of cisapride with vardenafil is contraindicated.

Citalopram: (Major) Citalopram causes dose-dependent QT interval prolongation.

According to the manufacturer, concurrent use of citalopram with other drugs that prolong the QT interval is not recommended.

If buy 10 viagra pills concurrent therapy is considered essential, ECG monitoring is recommended. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with citalopram include vardenafil. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction).

Clarithromycin: (Major) The manufacturer of clarithromycin (a CYP3A4 inhibitor) recommends against concomitant use with vardenafil (a CYP3A4 substrate); as use of these drugs together will result in increased vardenafil exposure. If these drugs must be administered concurrently, use the regular tablet formulation of vardenafil at a dose not to exceed 2.5 mg every 24 hours. The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, use of the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors is not advised. In addition, clarithromycin and vardenafil have been associated with prolongation of the QT interval; use of these drugs together may increase the risk for QT prolongation.

Class IA Antiarrhythmics: (Major) The manufacturer recommends that vardenafil be avoided in patients taking Class IA antiarrhythmics (disopyramide, procainamide, and quinidine). Class IA antiarrhythmics are associated with QT prolongation and torsades de pointes (TdP).

Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil produces an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction) The effect of vardenafil on the QT interval should be considered when prescribing the drug.

Clofazimine: (Major) Monitor ECGs for QT prolongation when clofazimine is administered with vardenafil.