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If you have a physical problem affecting your penis, getting priapism with Viagra could cause further damage to your penis.

Talk with your doctor about whether Viagra is right for you. If you have a blood cell problem, such as sickle cell anemia, multiple myeloma, or leukemia, Viagra may not be safe for you. This is because having these conditions could increase your risk of priapism (a long-lasting and sometimes painful erection) with Viagra. Talk with your doctor about whether Viagra is right for you. Non-arteritic anterior ischemic optic neuropathy (NAION).

NAION is an eye condition that causes damage to your optic nerve. This damage causes a sudden decrease or loss of vision in one or both eyes.

If you’ve already had this eye condition in the past, you could have a higher risk of developing it with Viagra.

Talk with your doctor about whether Viagra is right for you.

This condition, which affects your eye, is passed down in families. Viagra hasn’t been studied in people with hereditary retinitis pigmentosa. Talk with your doctor about any eye problems you may have.

If you have certain kidney problems and your kidneys don’t work well,Viagra can build up in your body. This can increase your risk of side effects from the drug. If you have severe kidney problems, your doctor will prescribe a dosage of Viagra for you that’s lower than the typical dosage.

If you have certain liver problems and your liver doesn’t work well, Viagra can build up in your body. This can increase your risk of side effects from the drug.

If you have liver problems, your doctor will prescribe a dosage of Viagra for you that’s lower than the typical dosage. There have been a few reports of bleeding in people who’ve

taken

However, there’s no evidence that Viagra caused these problems.

It’s not known if Viagra is safe for people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Viagra is right for you.

It’s not known whether Viagra is safe for people who have a peptic ulcer.

If you have or have had an ulcer in the past, talk with your doctor about whether Viagra is suitable for you.

For more information, please see the “Viagra and pregnancy” section below.

For more information, please see the “Viagra and breastfeeding” section below.

Note: For more information about the potential negative effects of Viagra, see the “Viagra side effects” section above. As with all medications, the cost of Viagra can vary. To find current prices for Viagra in your area, check out GoodRx.com.

The cost you find on GoodRx.com is what you may pay without insurance. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use. Your insurance plan may require you to get prior authorization before approving coverage for Viagra.

This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the request and let you and your doctor know if your plan will cover Viagra.

If you’re not

sure

Pfizer, the manufacturer of Viagra, offers a program that can help lower the cost of Viagra. For more information and to find out if you’re eligible for support, call 855-842-4722 or visit the program website.

Viagra is available in generic form called sildenafil.

A generic drug is an exact copy of the active drug in a brand-name medication.

The generic is considered to be as safe and effective as the original drug.

And generics tend to cost less than brand-name drugs. To find out how the cost of sildenafil compares to the cost of Viagra, visit GoodRx.com. Again, the cost you find on GoodRx.com is what you may pay without insurance.

The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.

If your doctor has prescribed Viagra and you’re interested in using sildenafil instead, talk with your doctor. They may have a preference for one version or the other.

You’ll also need to check your insurance plan, as it may only cover one or the other. It’s not known whether this drug is safe to take during pregnancy. In animal studies, Viagra didn’t cause fetal harm when given to pregnant females. But animal studies don’t always predict what will happen in humans. If you have questions about the safety of Viagra use during pregnancy, talk with your doctor.

It’s not known if Viagra is safe to take during pregnancy.

(But keep in mind that the drug isn’t approved for use in women.) If you’re sexually active and you or your partner can become pregnant, talk with your doctor about whether you’ll need to use birth control while you’re taking Viagra. And it hasn’t been studied in women who are breastfeeding. Viagra may pass into breast milk, but it’s not known if this could affect a nursing child.

If you have questions about the safety of using Viagra while breastfeeding, talk with your doctor.

The following information is provided for clinicians and other healthcare professionals.

Viagra is approved to treat erectile dysfunction (ED) in males ages 18 years and older.

It should be taken between 30 minutes and 4 hours before planned sexual activity.

Viagra contains sildenafil citrate, an inhibitor of phosphodiesterase type 5 (PDE5).

Viagra enhances the action of cyclic GMP, which is released in the penis in response to sexual stimulation. Cyclic GMP dilates smooth muscle in the penile tissue.

It also increases blood to flow into the corpus cavernosum, causing an erection. Viagra blocks PDE5 from breaking down cyclic GMP, thereby improving the ability to achieve and maintain an erection in response to sexual stimulation.

Sildenafil has an average bioavailability of 41% (ranges from 25% to 63%) after oral administration of Viagra tablets. When taken on an empty stomach, the time to reach peak plasma concentration (Tmax) is approximately 30 to 120 minutes.

Taking Viagra with a high-fat meal delays Tmax by about 60 minutes. It also reduces the maximum plasma concentration (Cmax) by an average of 29%.

Sildenafil is primarily metabolized by hepatic CYP3A4, to a metabolite with similar activity to sildenafil. Sildenafil and its active metabolite have a terminal half-life of approximately 4 hours.

Approximately 80% of the dose is excreted in feces, and approximately 13% is excreted in urine.

Reduced clearance of sildenafil is seen in people ages 65 years and over, and in those with hepatic impairment or severe renal impairment. Viagra is contraindicated in people with a known allergy to sildenafil, or any of the inactive ingredients in Viagra. Viagra is also contraindicated for use in combination with: nitrate drugs in any form, such as: nitroglycerin (Nitromist, Nitro-Dur, Nitrolingual Pumpspray, Gonitro, others) isosorbide mononitrate (Monoket) guanylate cyclase stimulators, such as riociguat (Adempas) Storage.

Store Viagra at room temperature between 68 o F and 77°F (20 o C and 25°C).

Disclaimer: Medical News Today has made every effort to

make

However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Braz J Med Biol Res, September 2005, Volume 38(9) 1303-1311 (Review) Effect of sildenafil citrate on the cardiovascular system.

Cardiac Electrophysiology Unit, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Sildenafil citrate is a drug commonly used to manage erectile dysfunction.

It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1 H -pyrazolo[4,3- d ]pyrimidin-5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C 22 H 30 N 6 O 4 S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5.

In late March through mid-November 1998, the US Food and Drug Administration (FDA) published a report on 130 confirmed deaths among men (mean age, 64 years) who received prescriptions for sildenafil citrate, a period during which >6 million outpatient prescriptions (representing about 50 million tablets) were dispensed. The US FDA recently reported that significant cardiovascular events, including sudden cardiac death, have occurred in men with erectile dysfunction who were taking sildenafil citrate. These reports have raised concerns that sildenafil citrate may increase the risk of cardiovascular events, particularly fatal arrhythmias, in patients with cardiovascular disease. In the past few years, the cardiac electrophysiological effects of sildenafil citrate have been investigated extensively in both animal and clinical studies. According to extensive data available to date, sildenafil citrate has been shown to pose minimal cardiovascular risks to healthy people taking this drug. Some precautions are needed for patients with cardiovascular diseases.

However, the only absolute contraindication for sildenafil citrate is the concurrent use of nitrates.

This article is intended to review sildenafil citrate's cardiovascular effects, as well as current debates about its arrhythmogenic effects.

Key words: Sildenafil citrate, Erectile dysfunction, Sudden cardiac death, Cardiovascular disease, Phosphodiesterase inhibitor, Cardioprotection. Sildenafil citrate was the first oral drug approved for the treatment of erectile dysfunction (ED), which is frequently observed in men with cardiovascular disease (1). ED is defined as the inability to achieve and/or maintain an erection sufficient for satisfactory sexual activity (2).

The prevalence of moderate to complete ED has been reported to be >30% in men aged 40 to 70 years (3). Since the approval of sildenafil citrate, several reports of sudden death among patients treated with this drug have raised some concerns regarding its safety in patients with coronary artery disease (4). In the past few years, the cardiovascular effects of sildenafil citrate have been investigated extensively in both animal and clinical studies.

In this article we shall review these studies, as well as the current debate about sildenafil citrate's arrhythmogenic effects. ED is a common health concern among patients with cardiovascular disease.

According to the Massachusetts Male Aging Study, 34.8% of men aged 40 to 70 years have moderate to complete ED, and 15% of men aged 70 have complete ED (3).