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Once a safety and effectiveness review is completed, a summary safety review is published to inform Canadians of what was found and what action was taken by Health Canada, if any.

Dopamine Agonist Withdrawal Syndrome (DAWS, mental and physical withdrawal symptoms after stopping or reducing the dose of dopamine agonists) Request from the Therapeutic Products Directorate, Health Canada. Aplastic anemia (disease when the body stops producing enough new blood cells) Cytokine release syndrome (severe inflammatory response in the

body

) Tumour lysis syndrome (quick cancer cells breakdown severely affecting many organs) No safety and effectiveness reviews started between 2019-07-01 and 2019-07-31.

No safety and effectiveness reviews started between 2019-06-01 and 2019-06-30. No safety and effectiveness reviews started between 2019-05-01 and 2019-05-31.

Dysglycaemia (abnormality in blood sugar stability - can include low blood sugar or high blood sugar.

Pancreatitis (inflammation of the pancreas) European Medicines Agency Assessment. Hepatocellular carcinoma (liver cancer) Follow up to previous review completed in 2016.

Safety and effectiveness reviews started between 2018-11-01 and 2018-11-30. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) Ongoing sexual dysfunction after stopping the use of the drug. Pharmacovigilance Risk Assessment Committee - European Medicines Agency.

Breast Implants (Allergan, Inc.; Mentor Medical Systems, B.V; MENTOR; IDEAL) Breast implants linked to anaplastic large cell lymphoma - BIA-ALCL (rare type of blood cancer) Many articles and foreign agency notices.

Aortic aneurysm (balloon-like bulge in an artery) and dissection (separation or tear in the layers of the wall of the aorta) Pharmacovigilance Risk Assessment Committee - European Medicines Agency. Fournier's gangrene - necrotizing fasciitis (progressive inflammatory infection) of the perineum (area between the anus and the scrotum or vulva) Foreign Agency (The U.S Food and Drug Administration) Suicidality (suicidal thoughts and behaviours) European Medicines Agency. U by kotex sleek tampons (Medical device) Fraying (wearing away) leading to increased risks of toxic shock syndrome and related symptoms.

Priapism (persistent and painful erection of the penis) Drug reaction with eosinophilia and systemic symptoms (DRESS) Drug manufacturer (Voluntary Post Market Vigilance) Drug manufacturer (Periodic Safety Update Report (PSUR)) Contact lenses (medical devices) Limbal stem cell deficiency (loss of stem cells (cells that can develop into different types of cell) in the limbus (border of the cornea and the sclera)) Liquid-filled intragastric balloon (medical device) Death, acute pancreatitis (sudden inflammation of the pancreas), gastric perforation ( hole

that

develops through the wall of the stomach), esophageal perforation (hole in the esophagus), spontaneous over-inflation (sudden excessive increase in size) Foreign Agency ( The U.S. Food and Drug Administration (US FDA) Prescription opioids - cough and cold indication. Opioid use disorder (misuse/overdose) in pediatrics (children) Urogynaecological (transvaginal) synthetic meshes (medical devices) Various mesh (net-like implant) related complications. Many sources including previous Health Canada Safety Reviews. Ceftriaxone sodium, amoxicillin, amoxicillin trihydrate.

Drug reaction with eosinophilia and systemic symptoms (DRESS), Severe cutaneous (skin) adverse reactions (SCAR) Potential drug interaction (with Crestor) due to suppression of p-glycoprotein. Linear IgA bullous dermatosis (rare disease due to autoimmune reaction) VEGF Receptor Inhibitors: (Caprelsa, Iclusig, Inlyta, Lenvima, Nexavar, Stivarga Sutent, Votrient) Axitinib, lenvatinib, pazopanib, ponatinib, regorafenib, orafenib, sunitinib, vandetanib.

Aortic dissection (serious condition in which the inner layer of the aorta, the large blood vessel branching off the heart, tears) Severe cutaneous (skin) adverse reactions (SCAR) (Jardiance, Qtern, Synjardy, Glyxambi, Xigduo, Forxiga, Invokana, Invokamet) Empagliflozin, linagliptin, dapagliflozin, saxagliptin, metformin hcl, canagliflozin. Posterior reversible encephalopathy syndrome (PRES) (rare brain condition) in amoxicillin capsule 500 association with diabetic ketoacidosis (high levels of acids in the blood) Therapy ablation catheters (medical devices) Atrioesophageal fistula (AEF) (abnormal connection between the heart and digestive tract) Thrombocytopenia (a condition in which the blood platelet count is low) Duovisc viscoelastic solution, provisc viscoelastic solution, viscoat ophthalmic viscoelastic

device

, cellugel viscosurgical device, discovisc ophthalmic viscosurgical device (medical devices) Toxic Anterior Segment Syndrome (TASS) (an acute inflammatory reaction in which a noninfectious substance

enters

the eye anterior segment and induces toxic damage to the surrounding tissues) Progressive multifocal leukoencephalopathy (a serious brain infection) QT prolongation and torsade de pointes (heart rhythm problem) Severe (skin) cutaneous adverse reactions (SCAR) Green tea extract.

(Primene, Prosol, Clinimix, Olimel, Travasol, Smofkabiven, Aminosyn) Increased mortality in pre-term infants (premature babies who are born before 37 completed weeks of gestation) when solution is not shielded (protected) from light. Renal (kidney) injury, including acute renal failure.

(Januvia, Janumet, Onglyza, Komboglyze, Trajenta, Jentadueto, Nesina, Kazano, Oseni) Sitagliptin, saxagliptin, linagliptin, alogliptin, (metformin combination) Serious arthralgia (joint pain) Gadolinium containing products. (Magnevist, Gadovist, Omniscan, Multihance, Optimark, Prohance, Primovist) Gadoversetamide, gadobutrol, gadopentetate, gadobenate, dadodiamide, gadoteridol, gadoxetate. Build-up of the Gadolinium containing products in the brain. Hematological disorders (disorders mainly affecting the blood) in neonates (newborns) Gastrointestinal perforation (hole that develops through the wall of the stomach, small intestine, large intestine, gallbladder or rectum.

No safety reviews were started between 2015-11-01 and 2015-11-30. Safety reviews started between 2015-10-01 and 2015-10-31 Brand Name or Product Class / Medical Device(s) Medicinal Ingredient(s) Potential Safety Issue Forxiga, Invokana, Jardiance (SGLT2 class inhibitors) Dapagliiflozin, canagliflozin, empagliflozin Increased risk of bone fractures, due to loss of bone mineral density Avonex, Betaseron, Extavia, Plegridy, Rebif (Beta-interferons) Interferon beta Risk of pulmonary arterial hypertension (type of high blood pressure that affects the arteries in the lungs and the right side of the heart).

Safety reviews started between 2015-07-01 and 2015-09-30 Brand Name or Product Class / Medical Device(s) Medicinal Ingredient(s) Potential Safety Issue.

Atypical Antipsychotic: Abilify, Clozaril, Invega, Latuda, Risperdal, Seroquel, Zeldox, Zyprexa. Aripiprazole, clozapine, paliperidone, lurasidone, risperidone, quetiapine, ziprasidone, olanzapine.

Urinary retention (temporary difficulty urinating and incomplete bladder emptying) Neisseria meningitidis group B.

Safety of vaccination with Bexsero in older patients.

Digoxin, Apo-Digoxin, Lanoxin, PMD-digoxin, Toloxin.

Increased mortality (death) Dimetane Expectorant DC, Tussionex, PMS-hydrocodone, Novahistine, Dalmacol, Hycodan, Novahistex DH, Ratio-calmydone, Tramacet, Zytram, Tridural, Ralivia, Ultram, Durela, and generic formulations of tramadol. Life-threatening respiratory depression (very slow breathing requiring emergency care) in children. Ovarian cancer in menopausal women (a type of cancer detected in the ovaries) Rivastigmine hydrogen tartrate.

Increased mortality (death) Progressive multifocal leukoencephalopathy (a serious brain infection) Malignancies (tumors which are cancerous and can cause serious illness or death), neoplasms (new and abnormal growth of tissues) Hepatitis A inactivated. Immune thrombocytopenic purpura (ITP) (a disorder that can lead to easy or excessive bruising and bleeding) Raynaud's phenomenon (disorder that causes some areas of the body to feel numb and cold as a result of a limited blood circulation) Drug-drug interaction with methotextrate. Use of Soliris in patients that are receiving meningococcal B vaccine at the same time. Capillary leak syndrome (disorder that can lead to a leak of fluid from the blood vessels into the body's tissues) Amoxicillin for clinically unsuspected pneumonia in primary care: subgroup analysis. Find this author on Google Scholar Find this author on PubMed Search for this author on this site. Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: b.d.l.broekhuizen@umcutrecht.nl. Find this author on Google Scholar Find this author on PubMed Search

for

this author on this site. Find this author on Google Scholar Find this author on PubMed Search for this author on this site. Find this author on Google Scholar Find this author on PubMed Search for this author on this site. Find this author on Google Scholar Find this author on PubMed Search for this author on this

site

. Antibiotic treatment is recommended for pneumonia [1, 2]. However, some studies have suggested that the milder spectrum of pneumonia in primary care does not have important adverse consequences if

missed

and, therefore, managed without antibiotics [3–5].

Better insight in the effects of antibiotics for pneumonia in amoxicillin for pimples primary care could improve patient information and management.

Antibiotic treatment is recommended for pneumonia [1, 2]. However, some studies have suggested that the milder spectrum of pneumonia in primary care does not have important adverse consequences if missed and, therefore, managed without antibiotics [3–5]. Better insight in the effects of antibiotics for pneumonia in primary care could improve patient information and management.

The aim of our study was to assess whether antibiotic treatment influenced

outcome

in patients presenting with acute lower respiratory tract infection (LRTI) with a radiologically proven, but clinically unsuspected, pneumonia compared to those without pneumonia. This was a secondary analysis of a randomized, placebo controlled trial of amoxicillin for acute LRTI in 16 primary research networks in 12 European countries from October 2007 until April 2010.

More details on this GRACE-10 study (Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe, www.gracelrti.org) have been reported elsewhere [6]. Eligible patients were aged ?18 years who consulted their general practitioner (GP) for the first time with an acute cough (duration of ?28 days) as the main symptom.

Exclusion criteria were clinically suspected pneumonia [7], based on focal chest signs (focal crepitations and bronchial breathing) and systemic features (high fever, vomiting and severe diarrhoea); pregnancy, allergy to penicillin, treatment with antibiotics in the previous month and immunodeficiency. The study was approved by ethics committees in all participating countries and all participants provided written informed consent.

Patients who agreed to randomisation were allocated to receive amoxicillin (1 g three times daily for 7 days) or placebo, by the GP dispensing sequentially numbered randomised containers. GPs recorded patients' clinical signs, and comorbidities on a case report form. They also registered 14 baseline symptoms (cough, phlegm, shortness of breath, wheeze, runny nose, fever, chest pain, muscle aching, headache, disturbed sleep, feeling generally unwell, interference with normal activities/work, confusion/disorientation and diarrhoea) on a 4-point Likert-scale from “no problem” to “severe problem”. Baseline symptom severity was calculated by summing the scores of the symptoms and rescaling them to make them range between 0 and 100. Patients filled in a daily symptom diary during their illness for up to 28 days for the same symptoms on a 7-point Likert scale (0=no problem, 1=very little problem, 2=slight problem, 3=moderately bad, 4=bad, 5=very bad and 6=as bad as it could be). This diary was previously validated and shown sensitive to change [8]. If the diary was not returned after 4 weeks, brief information about symptom duration and severity were collected with either a short questionnaire or a standardised telephone call.

Chest radiographs were taken for each patient within 7 days of first presentation, but preferably within 3 days.

Pneumonia was determined by radiologists, who were blind to all other information when they judged chest radiographs.

In analysis reported here we defined pneumonia as all patients in whom the radiologist diagnosed pneumonia based on the chest radiograph [9]. Outcomes were duration of symptoms rated by patients as “moderately bad or worse” after initial presentation, symptom severity on days 2–4 after the index

consultation

, and worsening of illness, defined as a revisit to the GP with worsening symptoms, new symptoms, new signs, or illness necessitating admission to hospital within 4 weeks after the first consultation [6].



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