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Some antibiotics are not suitable for people with certain medical problems, or women who are pregnant or breastfeeding.

Only ever take antibiotics prescribed for you – never "borrow" them from a friend or family member.

Some antibiotics do not mix well with other medicines, such as the contraceptive pill and alcohol.

Read the information leaflet that comes with your medicine carefully and discuss any concerns with your pharmacist or GP.

There are hundreds of different types of antibiotics, but most of them can be classified into 6 groups.

Penicillins (such as penicillin and amoxicillin) – widely used to treat a variety of infections, including skin infections, chest infections and urinary tract infections Cephalosporins (such as cephalexin) – used to treat a wide range of infections, but some are also effective for treating more serious infections, such as septicaemia and meningitis Aminoglycosides (such as gentamicin and tobramycin) – tend to only be used in hospital to treat very serious illnesses such as septicaemia, as they can cause serious side effects, including hearing loss and kidney damage; they're usually given by injection, but may be given as drops for some ear or eye infections Tetracyclines (such as tetracycline and doxycycline) – can be used to treat a wide range of infections, but are commonly used to treat acne and a skin condition called rosacea Macrolides (such as erythromycin and clarithromycin) – can be particularly useful for treating lung and chest infections, or as an alternative for people with a penicillin allergy, or to treat penicillin-resistant strains of bacteria Fluoroquinolones (such as ciprofloxacin and levofloxacin) – are broad-spectrum antibiotics that were once used to treat a wide range of infections, especially respiratory and urinary tract infections. These antibiotics are no longer used routinely because of the risk of serious side effects. We are looking for volunteers to give us their views on health research, including research into coronavirus (COVID-19). Page last reviewed: 23 May 2019 Next review due: 23 May 2022.

More than 30 million people in the United States wrongly believe they are allergic to penicillin -- resulting in millions of dollars in added health care costs, adverse side effects from the use of more powerful antibiotics and a risk in the rise of dangerous antibiotic resistant infections. This misconception and public health threat could be corrected, said Christopher M.

Bland, clinical associate professor at the University of Georgia College of Pharmacy, by asking those who say they are allergic to penicillin to answer a simple one-page questionnaire and, if necessary, take a penicillin allergy skin test, or PAST.

"In many instances we don't have to go past the questionnaire," Bland said.

"We're finding out that what most of these patients think is an allergic reaction is really only a side effect that may have happened once and might never happen again. Patients tell us that they became dizzy or nauseated after taking penicillin years ago or that their father was allergic to penicillin, so they thought they were allergic as well." Bland said penicillin often gets blamed when it may not be the culprit.

Even those who may have once been allergic to penicillin are no longer allergic today, he said. After five years, studies show that half of the individuals who had an allergic reaction -- like hives, wheezing, shortness of breath or anaphylaxis -- to penicillin were no longer allergic. At 10 years, that number jumps to 80 percent, he said. In research presented recently at IDWeek, the international infectious diseases meeting in Washington, D.C., Bland and colleagues demonstrated how many penicillin allergies were removed from patient records after patients were interviewed by UGA pharmacy students. "We are able to reduce the number of those who think they have penicillin allergy by 20 percent right away, just by talking to them through our questionnaire," said Bland.

"Our pharmacy students were able to debunk the allergy claim by many patients just by getting a detailed history." While the Infectious Diseases Society of America has recommended that penicillin allergy assessment be promoted as a way to erase this label on medical records for those who are not allergic, most of the studies that have included PAST as a way to accomplish this have been done at academic medical centers by trained allergists. Bland and Bruce Jones, an infectious diseases clinical pharmacy specialist at St. Joseph's/Candler Health System and adjunct UGA College of Pharmacy assistant professor in Savannah, said this isn't necessary and can be done in hospitals that do not have dedicated trained allergists on staff. They are working with more than 50 hospitals throughout the country, sharing best practices that will allow PAST to be performed and medical records updated. In a grant-funded study, Bland and Jones found that PAST done on patients who believed that they were allergic to penicillin -- the most effective antibiotic available with the least side effects -- demonstrated no real allergy.

These research findings were published in Open Forum Infectious Diseases. The duo worked with nurses at Candler Hospital and found that skin testing can be done safely in a community hospital setting.

When skin testing was performed at the hospital by trained nurses, 98 out of 100 patients in the study who had a penicillin allergy on their medical record were deemed not be allergic to the antibiotic. This allowed for an immediate change to a penicillin type antibiotic for most patients, which is often safer and cheaper, improves outcomes and reduces adverse effects, the goal of the federal antimicrobial stewardship program requiring hospitals to ensure that antibiotics are used only when necessary.

In addition to the public health benefit, Bland estimated that health care savings would be in the tens of millions of dollars annually if patients could be switched back to penicillin from more costly antibiotic treatments. The study at Candler Hospital found an average cost savings of $350 a patient, which includes the cost of the skin test.

"Our goal is that every penicillin allergy is questioned and reconciled, with most coming off medical records and allowing patients to get the best antibiotic for their particular infection, which is often a penicillin." Antibiotic resistance. Antibiotics are medicines used to prevent and treat bacterial infections.

Antibiotic resistance occurs when bacteria change in response to the use of these medicines.

Bacteria, not humans or animals, become antibiotic-resistant.

These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria. Antibiotic resistance leads to higher medical costs, prolonged hospital stays, and increased mortality. The world urgently needs to change the way it prescribes and uses antibiotics. Even if new medicines are developed, without behaviour change, antibiotic resistance will remain a major threat. Behaviour changes must also include actions to reduce the spread of infections through vaccination, hand washing, practising safer sex, and good food hygiene.

Antibiotic resistance is rising to dangerously high

levels

in all parts of the world.

New resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases.

A growing list of infections – such as pneumonia, tuberculosis, blood poisoning, gonorrhoea, and foodborne diseases – are becoming harder, and sometimes impossible, to treat as antibiotics become less effective. Where antibiotics can be bought for human or animal use without a prescription, the emergence and spread of resistance is made worse. Similarly, in countries without standard treatment guidelines, antibiotics are often over-prescribed by health workers and veterinarians and over-used by the public. Without urgent action, we are heading for a post-antibiotic era, in which common infections and minor injuries can once again kill.

Antibiotic resistance is accelerated by the misuse and overuse of antibiotics, as well as poor infection prevention and control.

Steps can be taken at all levels of society to reduce the impact and limit the spread of resistance.

To prevent and control the spread of antibiotic resistance, individuals can: Only use antibiotics when prescribed by a certified health professional.

Never demand antibiotics if your health worker says you don’t need them.

Always follow your health worker’s advice when using antibiotics. Prevent infections by regularly washing hands, preparing food hygienically, avoiding close contact with sick people, practising safer sex, and keeping vaccinations up to date.

Prepare food hygienically, following the WHO Five Keys to Safer Food (keep clean, separate raw and cooked, cook thoroughly, keep food at safe temperatures, use safe water and raw materials) and choose foods that have been produced without the use of antibiotics for growth promotion or disease prevention in healthy animals.

To prevent and control the spread of antibiotic resistance, policy makers can: Ensure a robust national action plan to tackle antibiotic resistance is in place. Improve surveillance of antibiotic-resistant infections.

Strengthen policies, programmes, and implementation of infection prevention and control measures.

Regulate and promote the appropriate use and disposal of quality medicines.

Make information available on the impact of antibiotic resistance. To prevent and control the spread of antibiotic resistance, health professionals can: Prevent infections by ensuring your hands, instruments, and amoxicillin 500mg no prescription environment are clean. Only prescribe and dispense antibiotics when they are needed, according to current guidelines. Report antibiotic-resistant infections to surveillance teams.

Talk to your patients about how to take antibiotics correctly, antibiotic resistance and the dangers of misuse.

Talk to your patients about preventing infections (for example, vaccination, hand washing, safer sex, and covering nose and mouth when sneezing). To prevent and control the spread of antibiotic resistance, the health industry can: Invest in research and development of new antibiotics, vaccines, diagnostics and other tools.

To prevent and control the spread of antibiotic resistance, the agriculture sector can: Only give antibiotics to animals under veterinary supervision. Not use antibiotics for growth promotion or to prevent diseases in healthy animals. Vaccinate animals to reduce the need for antibiotics and use alternatives to antibiotics when available. Promote and apply good practices at all steps of production and processing of foods from animal and plant sources. Improve biosecurity on farms and prevent infections through improved hygiene and animal welfare.

While there are some new antibiotics in development, none of them are expected to be effective against the most dangerous forms of antibiotic-resistant bacteria.

Given the ease and frequency with which people now travel, antibiotic resistance is a global problem, requiring efforts from all nations and many sectors. When infections can no longer be treated by first-line antibiotics, more expensive medicines must be used. A longer duration of illness and treatment, often in hospitals, increases health care costs as well as the economic burden on families and societies.



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