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The nodular lesions consist of newly formed blood vessels (neovascular proliferation) infiltrated by certain white blood cells that play an important role in fighting and destroying invading microorganisms (e.g., lymphocytes, macrophages).

Trench fever: Trench fever is caused by infection with B.

quintana most likely transmitted by the human body

louse

( Pediculus humanus ) and is commonly found in homeless, alcoholic, and poverty-stricken populations where poor sanitation and poor hygiene often occurs. Other diseases that have been identified to be caused by B.

quintana include bacillary angiomatosis (angioproliferative lesions), bacteremia, and endocarditis. Human endocarditis has now been associated with at least nine different Bartonella spp. berkhoffii has been isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia.

Dogs and wild canines (foxes, coyotes, wolves), which are the primary reservoir hosts, are the suspected reservoir hosts for this bacterium, and ticks are the suspected vectors, but this has not been scientifically proven.

Most infections in immunocompromised patients are caused by B. Unlike immunocompetent individuals who usually develop milder diseases such as cat scratch disease and trench fever, immunocompromised patients, including HIV/AIDS and posttransplant patients, are more likely to develop more severe, potentially life-threatening disease.

hensela e infection occurs in approximately 1 per 10,000 persons. Cat-scratch disease has been shown in some studies to occur more frequently in males than females with a ratio of 3:2.

However, other studies have shown equal rates between males and females.

One hypothesis to explain a greater incidence

among

males than females is the tendency toward rougher play with cats and consequently an increased risk of bites and scratches.

A database analysis in 2016 showed 33% of patients with CSD were 14 years of age or younger. Cases of CSD occur throughout the United States and worldwide, with

the

incidence greater in regions with higher temperatures and humidity, which supports heavy flea populations.

In the United States, the majority of cases occur between the months of July and January.

One study in 2016 concluded that incidence of CSD in the United States is higher in the South and lower in the West.

Carrion’s disease has, until recently, been restricted in its geographic distribution to the Andes Mountains regions of the South American countries of Colombia, Peru, and Ecuador at elevations of 1000-3000 meters because of the habitat of the sand fly Lutzomyia.

Cases elsewhere in the world are found in travelers, who presumably acquired their infections while visiting one of these countries. Oroya fever was first recognized in the nineteenth century as the cause of acute fever and highly fatal, hemolytic anemia in railroad workers in Peru.

Reports suggest that the chronic skin (cutaneous) stage was described earlier. The common bacterial cause of Oroya fever and verruga peruana was confirmed by a Peruvian medical student, Daniel Carrion, in 1885, when he succumbed to acute hemolytic anemia after injecting himself with blood from a verruga peruana skin lesion.

bacilliformis infection as manifested in Oroya fever and verruga peruana has since been named “Carrion’s Disease.” Trench fever was first described during World War I when it affected nearly

one

million soldiers.

quintana has caused geographically widespread disease, although little data exists regarding incidence among specific populations. Though the true incidence of contemporary (urban) trench fever is unknown, one study of patients in a downtown Seattle clinic for disadvantaged patients found 20% had antibodies to Bartonella spp., though most of these patients were asymptomatic. Certain features of the following disorders may be similar to those of bartonellosis: Adenitis (Bacterial, Fungal, Pyogenic, and Tuberculous) is an inflammatory disease characterized by lymphadenopathy.

Differential diagnosis may be accomplished through skin testing and/or microscopic examination of the involved lymph nodes.

Atypical

mycobacterial infections are caused by nontuberculous mycobacteria, but can be very difficult to distinguish from tuberculosis.

Lymphadenopathy is caused by nontuberculous mycobacteria, surgical removal and examination (biopsy) of involved tissue may be necessary for diagnosis. Brucellosis is an infection of livestock that can be transmitted to humans.

It is caused by different species of the bacteria Brucella.

Initial infection may result in an acute flu-like illness, or may evolve over months.

Untreated cases may take months to resolve, and some cases become chronic. Symptoms may include a gradual onset of fever, weakness, headache, joint pain, and/or night sweats.

Other symptoms may include lymphadenopathy, splenomegaly, and/or hepatomegaly. (For more information on this disorder, choose “Brucellosis” as your search term in the Rare Disease Database.) Lymphogranuloma venereum is a sexually transmitted infection characterized by a primary skin lesion at the site of infection. This lesion may be a raised bump (papule) that heals spontaneously or may go unnoticed. This is followed by lymphadenopathy on one or both sides of the body.

The site of the first infection or lesion will determine the region affected. Lymphomas are growths (tumors) of the lymphoid tissue. These tumors are divided into two types, Hodgkin’s and non-Hodgkin’s lymphoma. Symptoms will depend upon the type and location of the tumor. Symptoms may include lymphadenopathy, hoarseness, a high- pitched respiratory sound when inhaling (stridor), and/or difficulty in swallowing (dysphagia). Sarcoidosis is a rare disorder which affects many body systems.



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