31.08.2014
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Clinical response rates among clinically evaluable patients requiring mechanical ventilation at study entry in astudy of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Clinical response rates among clinically evaluable patients requiring mechanical ventilation at study entry in astudy of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Thirty patients required vasopressor therapy during the study because of the severity of their illness. For this group of patients, clinical success was demonstrated in 68.8% of patients treated with levofloxacin (11 of 16 patients) and in 50% of patients treated with the comparator (7 of 14 patients) ( table 7). Clinical response rates among clinically evaluable patients requiring vasopressor therapy in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Clinical response rates among clinically amoxicillin 500mg no prescription evaluable patients requiring vasopressor therapy in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. A secondary efficacy variable was microbiological eradication. Among patients evaluable for microbiological efficacy, the overall post therapy eradication rates for pathogens were 87.7% (64 of 73 patients) and 81.8% (81 of 99 patients) for the levofloxacin and comparator arms, respectively (95% CI, ?17.3 to 5.5). Rates of eradication of infection were 84.9% (45 of 53 patients) for the levofloxacin group and 75.0% (48 of 64 patients) for the comparator group (95% CI, ?25.2 to 5.4)( table 8). Microbiological eradication rates for microbiologically evaluable patients in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Microbiological eradication rates for microbiologically evaluable patients in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Culture results demonstrated a broad range of organisms in addition to those not typically associated with CAP. This range of organisms included some gram-negative organisms more typically associated with nosocomial pneumonia ( table 9). For patients with the aforementioned organisms more typically associated with nosocomial pneumonia, microbiological eradication occurred in 81.8% of patients in the levofloxacinarm (9 of 11 patients) and in 80% of patients in the comparator arm (12 of 15 patients) ( table 10). Range of suspected pathogens isolated from patients in the intent-to-treat population in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Range of suspected pathogens isolated from patients in the intent-to-treat population in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Eradication of pathogens more typically associated with nosocomial pneumonia from the microbiologically evaluable population in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. Eradication of pathogens more typically associated with nosocomial pneumonia from the microbiologically evaluable population in a study of the safety and efficacy of levofloxacin for the treatment of community-acquired pneumonia. All 269 patients who were enrolled in the study were evaluable for safety. Both the levofloxacin and the comparator treatment regimens were safe and well tolerated. The types of treatment-emergent adverse events reported in the present study were consistent with the known safety profiles of these agents. Overall, in the population evaluable for safety, 74.2% of patients in the levofloxacin treatment group (98 of 132 patients) and 70.1% of patients in the comparator treatment group (96 of 137 patients) reported ?1 treatment-emergent adverse event during the study. Gastrointestinal disorders were the most common complaints in both treatment groups; 37.1% of levofloxacin-treated patients (49 of 132 patients) and 43.1% of comparator-treated patients (59 of 137 patients) reported gastrointestinal disorders. Application-site disorders were more common among patients treated with the comparator, occurring in 8% of comparator-treated patients (11 of 137 patients), compared with 0.8% of patients treated with levofloxacin (1 of 132 patients). Twenty-four patients died during the study or within 30 days of receipt of the last dose of study medication (11.4% of patients in the levofloxacin-treatment group [15 of 132 patients] and 6.6% of patients amoxicillin pregnancy uti in the comparator-treatment group [9 of 137 patients]). None of the deaths was considered to be related to study therapy. The average APACHE II score for patients in the levofloxacin group who died was 20.0; for patients in the comparator group who died, the average score was 18.5. There was no statistically significant difference between mortality rates in the 2 groups ( P = .20, by Fisher exact test). The patient population included in this study was seriously ill. All patients were hospitalized for treatment and either required mechanical ventilation or had serious vital-sign abnormalities and/or altered mental status. The average APACHE II score at study entry was ?16 for both groups.
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