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That improves your blood flow and helps you get an erection. For the drugs to work, you need to be sexually aroused. The International Society for Sexual Medicine defines erectile dysfunction as a man’s inability to achieve or maintain an erection suitable for satisfactory sex. In order to understand erectile dysfunction, it is important to understand how erections occur. When a man is sexually aroused, nerves and camber pharmaceuticals sildenafil chemicals work together to relax smooth muscle tissue and widen arteries so that the penis can fill with blood. Veins constrict to keep the blood inside the penis, forming the erection. Once the man ejaculates, the blood is released back into the body. Erectile dysfunction becomes more common as men get older. It is also associated with some medical conditions, like heart disease and diabetes. In fact, an estimated 50% of diabetic men have some degree of erectile dysfunction. Smoking: It increases your risk of hardening of the arteries. It’s that blood flow that helps you get an erection; Being overweight: Carrying extra pounds increases your risk of blood vessel disease, a cause of erectile dysfunction; Inactive lifestyle: If you want to reduce your chance of getting erectile dysfunction, get off the couch. Regular exercise can camber pharmaceuticals sildenafil help to make sure that when the time comes, you’re ready; Poorly managed diabetes: Diabetes can affect blood flow to your penis. Maintain a healthy diet, get regular exercise, and take your medicine as prescribed; High cholesterol: It can damage the linings of blood vessels, including those in the penis. It can also affect the arteries leading to your genitals. Eat right, exercise regularly, and take your meds; Alcohol: If you have more than two drinks a day, you could be hurting your ability to get an erection. Alcohol restricts blood flow to the penis and can hinder the production of testosterone. Low testosterone can affect not only your performance but your desire, too; Illegal drug use: Marijuana, cocaine, and other recreational drugs can cause erectile dysfunction by damaging blood vessels. They can also restrict blood flow to the penis; Stress and anxiety: These are the leading causes of temporary erectile dysfunction. If your mind’s too occupied, it’s hard to relax enough to be “in the mood”. The incidence of erectile dysfunction increases with increasing age. Men aged 18-59 years have an incidence of erectile dysfunction of 10%. Other data looking at similar groups divided the age groups into sildenafil citrate cvs 10-year sections and found that, by setting individuals aged 18-29 years as a reference group, individuals aged 50-59 years had a 3.5 times higher incidence of erectile dysfunction. Another survey found that males older than 70 years had a 61% incidence of erectile dysfunction. These approaches may reduce both the man’s and his partner’s anxiety, enhance arousal, and offer pleasurable options, which may reduce the man’s stress; Oral medications. Phosphodiesterase type 5 (PDE5) inhibitors help increase blood flow to the penis. These drugs are usually the first method patients try, but they should not be used by men who take nitrates; Penile injections. This medication helps blood vessels dilate, allowing more blood for erection; Urethral suppositories. These medications are inserted into the urethra at the tip of the penis; Vacuum erection devices. The man places his penis into a vacuum cylinder and pumps air out. He then places a constriction ring at the base of the penis, which keeps the erection; Penile implants. Implants are surgically placed inside the penis and allow a man to get an erection when he wishes. The current four oral erectile dysfunction drugs all belong to the same drug class; that is, phosphodiesterase type 5 inhibitors, or PDE-5. The drug options include sildenafil (Viagra), tadalafil (Cialis), avanafil (Stendra) and vardenafil (Levitra). Research has shown that these PDE-5 inhibitors are similar when it comes to efficacy and safety, but there are some differences regarding timings to consume, the impact of diet on how well they are absorbed, how long they last, and some minor side effects. These factors play a significant role in helping men decide which erectile dysfunction drug is best for their needs and lifestyle. Men also may take into consideration their and their partners’ preferences, such as how spontaneous they are when it comes to sexual activity, and cost. In 2011 a meta-analysis camber pharmaceuticals sildenafil compared the use of three erectile dysfunction drugs–sildenafil, tadalafil, and vardenafil, among more than 7,700 men. The investigators found that men consistently preferred tadalafil (Cialis) (52-65%) over the other two (12-20% for vardenafil; 8-30% for sildenafil). Although all three drugs were shown to be safe and effective, tadalafil offered men a 36-hour window of opportunity for getting an erection, while the other two provided a much shorter time period. But if you want, you can compare the general characteristics of erectile dysfunctions drugs. These facts, along with your personal preferences and lifestyle habits, can help when choosing which erectile dysfunction drug is best for you. Viagra (Sildenafil) Begins to work within 30 to 45 minutes of ingestion; You can achieve successful erections for 2 to 3 hours, although the effects may last up to 5 hours at a higher dose; The recommended dose for most men is 50mg; after that, dosage may go to as high as 100mg, or as low as 25mg, which may be prescribed for men over 65; It is quickly absorbed by the body but less effective after a high-fat meal, and best taken on an empty stomach; Most common side effects are abnormal vision (blue-tinged vision, blurriness), back pain, dizziness, flushing, headache, muscle pain, nausea, rash, stuffy or a runny nose, and upset stomach. Rare effects include irregular heartbeat and stroke. Levitra (Vardenafil) Begins to work within 25 minutes, but it may take longer if you take it with a fatty meal; You can achieve successful erections for 4 to 5 hours after taking the pill; Starting dose for most men is 10mg a day, but men over 65 often start on the 5mg pill; Can be taken with or without food, although slightly less effective after a high-fat meal. Avoid anything containing grapefruit juice; it may make side effects worse; Most common side effects are a headache and facial flushing. Less common side effects include blue-tinged vision, dizziness, indigestion, nasal congestion, and nausea. Cialis (Tadalafil) Begins to work within 30 to 45 minutes after ingestion, although there have been reports that it can be effective within 15 minutes; You can achieve successful erections for up to 36 hours after taking the pill; Comes in two forms. The daily pill stays effective in between doses but may take 4 to 5 days before it begins working. The “weekender” version of Cialis can start working in as little as 30 minutes for men who take the highest dose of the drug (20mgs); it stays effective in the body for up for 36 hours; The daily pill comes in both a 2.5mg and 5mg tablet; most men start with the lower dose. The use-as-needed, “weekender” pill comes in 5, 10 and 20mg strengths; recommended starting dose is 10mg; Can be taken with or without food. Avoid heavy drinking (5 glasses of wine or five shots of whiskey); when combined with Cialis, it can lead to headaches, dizziness, an increase in heart rate, and a drop in blood pressure; Most common side effects are a headache and indigestion. Less often men experience back pain, dizziness, facial flushing, muscle aches, and nasal congestion; Integrated analysis of data from phase III trials demonstrated that tadalafil, at doses from 5 mg to 20 mg versus placebo, significantly improved erectile function (EF) by all measures. 50%–65% of patients, regardless of erectile dysfunction severity at baseline, returned to normal EF with almost 60%–90% of success rate at intercourse attempts during active treatment. Spedra (Avanafil) Prescribing information now recommends taking it 30 minutes before sex. Some men, however, report results in as little as 10 to 12 minutes, depending on the dose; You can achieve successful erections for more than six hours after taking the pill; The starting dose is 100mg for most men, but the 50mg tablet is recommended for men taking alpha-blocker drugs, like those used for high blood pressure and prostate problems; May be taken with or without food, and with a moderate amount of alcohol (3 drinks). Drinking more than that buy sildenafil cvs can increase the chances of side effects like rapid heart rate, low blood pressure, dizziness and headaches; Most common side effects are flushing, headache, nasal congestion, and runny nose. Symptoms such as back pain, diarrhoea, dizziness, hypertension, influenza, muscle aches, and upper respiratory infections are less common.; The percentages of successful intercourse attempt after taking each dose were as follows: The 50 mg dose had a 47% success rate; The 100 mg dose had a 58% success rate; The 200 mg dose had a 59% success rate. Sildenafil and vardenafil bind to cGMP, thereby blocking the PDE-5-mediated catalytic mechanism that dephosphorylates and breaks down cGMP. In contrast, tadalafil is structurally distinct from sildenafil and vardenafil and may inhibit PDE-5 by a slightly different mechanism. Selectivity for the different PDEs varies among these three agents. Subtle pharmacokinetic differences in PDE-5 inhibitors may influence clinical use, yet efficacy is likely to be very similar among these drugs. The efficacy of PDE-5 inhibitors varies from 40% to 85% depending on the severity and aetiology of erectile dysfunction. The ideal therapy camber pharmaceuticals sildenafil for erectile dysfunction should reverse or reduce the processes leading to corpus cavernosal smooth muscle dysfunction or lack of cavernous nerve activity. Erectile dysfunction is often due to the inability of the cavernous smooth muscle to relax. Events that prevent relaxation include nerve damage, endothelial dysfunction, or alterations in receptors or signal transduction pathways in cavernous smooth muscle. In general, patients with erectile dysfunction respond well to pharmacologic therapies. Only 10%–15% of men with erectile dysfunction fail to respond to currently available drugs. Erectile dysfunction drugs produce an erection enough for intercourse in about 70% of men. But the results vary quite a bit from one individual to another. A man with nerves or arteries damaged by prostate surgery, diabetes, or cardiovascular disease will have a different response to erectile dysfunction drugs. Before you take any of the other erectile dysfunction drugs, you should tell your healthcare provider about all medications and supplements you are taking, both prescription and over-the-counter. This is especially critical if you are taking nitrates because the combination can cause a drastic and sudden drop in blood pressure. You should also tell your doctor if you have ever had the following: Heart problems, such as heart attack, angina, heart failure, irregular heartbeat; Heart surgery within the last 6 months; Stroke; Low or high blood pressure; Peyronie’s disease; Priapism; Blood disease, such as multiple myeloma, leukaemia, sickle cell anaemia; Retinitis pigmentosa (a genetic eye disease); Bleeding problems; Stomach ulcers; Liver problems; Severe vision loss; Kidney problems; Any other medical conditions. Each drug comes with the chance of drug interactions. Since PDE-5 inhibitors work on the body in similar ways, Cialis, Levitra, and Viagra come with similar interactions. They also all interact with blood pressure drugs such as alpha-blockers. For Cialis, these also include the drugs enalapril and metoprolol. For Viagra, these also include the blood pressure drug amlodipine. Drinking alcohol with Cialis can cause low blood pressure when you stand up from a sitting or lying position. Levitra and Viagra do not seem to cause low blood pressure when taken with alcohol. However, alcohol may interfere with your ability to get an erection, even while you’re taking any of these drugs. You and your partner will still act just as you would if you were not taking a medicine for erectile dysfunction; Do not drink large amounts of alcohol before you plan to take an erectile dysfunction drug. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets; It is recommended that you do not drink grapefruit juice during the 24 hours before you take an erectile dysfunction drug. This is because there is a chemical in grapefruit juice which can increase the amount of avanafil in your bloodstream and this makes side effects more likely; Keep your regular appointments with your doctor so your progress can be monitored. If you feel the tablets are too strong for you, discuss this with your doctor as your dose may need to be reduced. Alternatively, if you do not get an erection after taking an erectile dysfunction drug, or if it does not last long enough for you to have sex, you should discuss this with your doctor; do not take more tablets than you have been told to. If you have erectile dysfunction, talk to your doctor about Cialis, Spedra, Levitra, and Viagra. Tell your doctor if you take other over-the-counter or prescription drugs or supplements. Be sure to mention all other health conditions you have. Different erectile dysfunction drugs suit different people, but it is difficult to tell which one will be best for you until you have tried them all. While an erectile dysfunction drug may not work for you first time around, it is recommended to take it at least eight times before giving up and trying another. This is because it can often take this long to determine whether a drug is right for you. Each of these three popular drugs has been shown to help men with erectile dysfunction when they’re used correctly. These drugs have good results, but it may take a little time and patience to get it right. If one drug doesn’t work or produces unpleasant side effects, you can try another drug. It may also take some time to find the dosage that works best for you. This chart compares 6 major erectile dysfunction (ED) drugs currently on the market: Viagra, Levitra, Cialis, Staxyn, Stendra, Caverject injections, and the MUSE suppository. Quickly absorbed by the body; slower absorption after a high-fat meal and best taken on an empty stomach. Avoid grapefruit juice, which can make side effects worse. The daily dosage is 2.5 mg but can go up to 5 mg; most men start with the lower dose. For use-as-needed, or as a weekend pill, the starting dose is camber pharmaceuticals sildenafil usually 10 mg but can be as low as 5 mg or as high as 20 mg. May be taken with or without food, and with a moderate amount of alcohol (three drinks). Drinking more than that can increase the chances of side effects like rapid heart rate, low blood pressure, dizziness, and headaches. -CHICAGO -- The highly specific PDE5 inhibitor Avanafil may work in as little as 15 minutes after dosing, researchers said here. by Kristina Fiore, Staff Writer, MedPage Today 2012-08-31. CHICAGO -- The newest drug for erectile dysfunction (ED) may work in as little as 15 minutes after dosing, researchers said here. A significantly larger proportion of patients had successful sexual encounters within 15 minutes of taking avanafil (Stendra) compared with placebo ( P ?0.05), John Mulhall, MD, of Memorial Sloan Kettering Cancer Center in New York, and colleagues reported here at the World Meeting on Sexual Medicine. "About half of attempts are successful in 15 minutes," Mulhall said. Approved last April, avanafil is the first ED drug to be introduced to the market in nearly a decade. It's a highly specific phosphodiesterase type 5 (PDE5) inhibitor that is rapidly absorbed, typically within 30 to 45 minutes. Note that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. The newest drug for erectile dysfunction (ED) may work in as little as 15 minutes after dosing. The drug was well tolerated, with the most common adverse event being headache, and fewer than 2% of patients discontinued due to an adverse event. Patients in the four randomized, controlled trials of the drug were told to take a dose 30 minutes before sexual activity, but 277 patients (18.3% of the sample) recorded intercourse attempts within 15 minutes of dosing. To evaluate their success rates, the researchers looked at responses to the Sexual Encounter Profile question 3 (SEP3). Patients took either placebo or one of three doses of the drug -- 50 mg, 100 mg, or 200 mg doses -- though most (75%) increased their dose to 200 mg. The population included diabetics, non-diabetics, and men who'd had bilateral, nerve-sparing radical prostatectomy, and about a third of patients had severe ED. Mulhall and colleagues found that significantly more men on the drug who attempted sex within 15 minutes were successful compared with those on placebo ( P ?0.05). For instance, 55% of those on 50 mg and 200 mg, as well as 57% of those on 100 mg, were successful, compared with 35% of those on placebo, he reported. Which Drug for Erectile Dysfunction Is Better: Viagra or Cialis? Four drugs have been approved for erectile dysfunction. Which is best depends on your individual needs and desires. The Food and Drug Administration has approved four similar drugs for erectile dysfunction, sold under such names as Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil) and Stendra (avanafil). They all work the same way, producing an erection by increasing blood flow to the penis. Which drug is best may depend on your preference for quick onset versus long duration and your individual medical needs. The discovery of Viagra is one of the classic stories of serendipity in drug development. In the 1980s, the pharmaceutical company Pfizer began studying sildenafil, the generic name for Viagra, as a treatment for heart disease. It didn’t work, but the men in the study developed unusually strong, long-lasting erections. All four of the currently approved drugs seem to be equally good at producing erections. But it is difficult to be more definitive in evaluating their efficacy, because few studies directly comparing them have been conducted, a common problem with many drugs. Since all four drugs are similarly effective, the answer to which drug is best will depend on other attributes, such as side effects, drug interactions, speed of onset and duration of action. Headache, flushing and upset stomach are the most common side effects. And, in rare cases, all can cause a persistent and sometimes painful erection that will not go down, a condition called priapism that can result in permanent damage if not treated promptly. Drug interactions are largely similar, with the most important interaction being a contraindication to nitrate-containing drugs, such as nitroglycerin, commonly used to treat angina. Time of onset is an important difference between the drugs. While all take effect within an hour, Stendra is the fastest acting, often taking effect within 15 minutes. Duration of action is another important difference between the drugs. Cialis is the longest acting, with a duration of up to 36 hours. Cialis’s long duration means that it can be taken once a day, eliminating the need to take a pill before each sexual encounter. Such once-a-day dosing has been reported to increase sexual self-confidence and spontaneity. Which drug is better depends on your personal situation. For long duration, and perhaps for spontaneity, Cialis may be best. As always, the answer must come from your doctor, who can assess patient-specific factors and help determine which is right for you. The number of men diagnosed with erectile dysfunction has skyrocketed ever since the little blue pill made it okay to talk about. Fortunately, the number of treatment options has increased, too. So, which ones are worth a shot, and which are just hype? In the 14 years or so since Viagra was introduced in 1998, the number of men diagnosed with erectile dysfunction (ED) has increased by a whopping 250 percent. Men are realizing more and more that they’re not alone and that they have options. Aside from pills like Viagra, Levitra, and Cialis, for example, there are surgical, therapeutic, even do-it-yourself treatments that can bring back that lovin’ feeling. "Some older ED treatments are actually being used more than ever, especially for men who can't take the pill," says Michael Feloney, MD, a urologist at the Nebraska Medical Center in Omaha. Read on to find out about nine common remedies for ED, plus the truth about which ones live up to the hype and which fall flat.
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