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Veins constrict to keep the blood inside the penis, forming the erection. Once the man ejaculates, the blood is released back into the body. Erectile dysfunction becomes more common as men get older.

It is also associated with some medical conditions, like heart disease and diabetes.

In fact, an estimated 50% of diabetic men have some degree of erectile dysfunction.

Smoking: It increases your risk of hardening of the arteries. It’s that blood flow that helps you get an erection; Being overweight: Carrying extra pounds increases your risk of blood vessel disease, a cause of erectile dysfunction; Inactive lifestyle: If you want to reduce your chance of getting erectile dysfunction, get off the couch.

Regular exercise can help to make sure that when the time comes, you’re ready; Poorly managed diabetes: Diabetes can affect blood flow to your penis.

Maintain a healthy diet, get regular exercise, and take your medicine as prescribed; High cholesterol: It can damage the linings of blood vessels, including those in the penis. It can also affect the arteries leading to your genitals.

Eat right, exercise regularly, and take your meds; Alcohol: If you have more than two drinks a day, you could be hurting your ability to get an erection.

Alcohol restricts blood flow to the penis and can hinder the production of testosterone. Low testosterone can affect not only your performance but your desire, too; Illegal drug use: Marijuana, cocaine, and other recreational drugs can cause erectile dysfunction by damaging blood vessels. They can also restrict blood flow to the penis; Stress and anxiety: These are the leading causes of temporary erectile dysfunction. If your mind’s too occupied, it’s hard to relax enough to be “in the mood”.

The incidence of erectile dysfunction increases with increasing age.

Men aged 18-59 years have an incidence of erectile dysfunction of 10%. Other data looking at similar groups divided the age groups into 10-year sections and found that, by setting individuals aged 18-29 years as a reference group, individuals aged 50-59 years had a 3.5 times higher incidence of erectile dysfunction. Another survey found that males older than 70 years had a 61% incidence of erectile dysfunction.

These approaches may sildenafil next day delivery reduce both the man’s and his partner’s anxiety, enhance arousal, and offer pleasurable options, which may reduce sildenafil next day delivery the man’s stress; Oral medications.

Phosphodiesterase type 5 (PDE5) inhibitors help increase blood flow to the penis. These drugs are usually the first method patients try, but they should not be used by men who take nitrates; Penile injections.

This medication helps blood vessels dilate, allowing more blood for erection; Urethral suppositories.

These medications are inserted into the urethra at the tip of the penis; Vacuum erection devices. The man places his penis into a vacuum cylinder and pumps air out. He then places a constriction ring at the base of the penis, which keeps the erection; Penile implants.

Implants are surgically placed inside the penis and allow a man to get an erection when he wishes.

The current four oral erectile dysfunction drugs all belong to the same drug class; that is, phosphodiesterase type 5 inhibitors, or PDE-5. The drug options include sildenafil (Viagra), tadalafil (Cialis), avanafil (Stendra) and vardenafil (Levitra).

Research has shown that these PDE-5 inhibitors are similar when it comes to efficacy and safety, but there are some differences regarding timings to consume, the impact of diet on how well they are absorbed, how long they last, and some minor side effects.

These factors play a significant role in helping men decide which erectile dysfunction drug is best for their needs and lifestyle. Men also may take into consideration their and their partners’ preferences, such as how spontaneous they are when it comes to sexual activity, and cost. In 2011 a meta-analysis compared the use of three erectile dysfunction drugs–sildenafil, tadalafil, and vardenafil, among more than 7,

700

Although all three drugs were shown to be safe and effective, tadalafil offered men a 36-hour window of opportunity for getting an erection, while the other two provided a much shorter time period.

But if you want, you can

compare

Rare effects include irregular heartbeat and stroke.

Levitra (Vardenafil) Begins to work within 25 minutes, but it may take longer if you take it with a fatty meal; You can achieve successful erections for 4 to 5 hours after taking the pill; Starting dose for most men is 10mg a day, but men over 65 often start on the 5mg pill; Can be taken with or without food, although slightly less effective after a high-fat meal.

Avoid anything containing grapefruit juice; it may make side effects worse; Most common side effects are a headache and facial flushing.

Less common side effects include blue-tinged vision, dizziness, indigestion, nasal congestion, and nausea. Cialis (Tadalafil) Begins to work within 30 to 45 minutes after ingestion, although there have been reports that it can be effective within 15 minutes; You can achieve successful erections for up to 36 hours after taking the pill; Comes in two forms.

The daily pill

stays

The “weekender” version of Cialis can start working in as little as 30 minutes for men who take the highest dose of the drug (20mgs); it stays effective in the body for up for 36 hours; The daily pill comes in both a 2.5mg and 5mg tablet; most men start with the lower dose. The use-as-needed, “weekender” pill comes in 5, 10 and 20mg strengths; recommended starting dose is 10mg; Can be taken with or without food.

Avoid heavy drinking (5 glasses of wine or sildenafil goodrx price five shots of whiskey); when combined with Cialis, it can lead to headaches, dizziness, an increase in heart rate, and a drop in blood pressure; Most common side effects are a headache and indigestion.

Less often men experience back pain, dizziness, facial flushing, muscle aches, and nasal congestion; Integrated analysis of data from phase III trials demonstrated that tadalafil, at doses from 5 mg to 20 mg versus placebo, significantly improved erectile function (EF) by all measures.

50%–65% of patients, regardless of erectile dysfunction severity at baseline, returned to

normal

Drinking more than that can increase the chances of side effects like rapid heart rate, low blood pressure, dizziness and headaches; Most common side effects are flushing, headache, nasal congestion, and runny nose.

Symptoms such as back pain, diarrhoea, dizziness, hypertension, influenza, muscle aches, and upper respiratory infections are less common.; The percentages of successful intercourse attempt after taking each dose were as follows: The 50 mg dose had a 47% success rate; The 100 mg dose had a 58% success rate; The 200 mg dose had a 59% success rate.

Sildenafil and vardenafil bind to cGMP, thereby blocking the PDE-5-mediated catalytic mechanism that dephosphorylates and breaks down cGMP.

In contrast, tadalafil is structurally distinct from sildenafil and vardenafil and may inhibit PDE-5 by a slightly different mechanism.

Selectivity for the different PDEs varies among these three agents.

Subtle pharmacokinetic differences in PDE-5 inhibitors may influence clinical use, yet efficacy is likely to be very similar among these drugs. The efficacy of PDE-5 inhibitors varies from 40% to 85% depending on the severity and aetiology of erectile dysfunction. The ideal therapy for erectile dysfunction should reverse or reduce the processes leading to corpus cavernosal smooth muscle dysfunction or lack of cavernous nerve activity. Erectile dysfunction is often due to the inability of the cavernous smooth muscle to relax.

Events that prevent relaxation include nerve damage, endothelial dysfunction, or alterations in receptors or signal transduction pathways in cavernous smooth muscle. In general, patients with erectile dysfunction respond well to pharmacologic therapies.

Only 10%–15% of men with erectile dysfunction fail to respond to currently available drugs.

Erectile dysfunction drugs produce an erection enough for intercourse in about 70% of men.

But the results vary quite a bit from one individual to another. A man with nerves or arteries damaged by prostate surgery, diabetes, or cardiovascular disease will have a different response to erectile dysfunction drugs. Before you take any of the other erectile dysfunction drugs, you should tell your healthcare provider about all medications and supplements you are taking, both prescription and over-the-counter.

This is especially critical if you are taking nitrates because the combination can cause a drastic and sudden drop in blood pressure.

You should also tell your doctor if you have ever had the following: Heart problems, such as heart attack, angina, heart failure, irregular heartbeat; Heart surgery within the last 6 months; Stroke; Low or high blood pressure; Peyronie’s disease; Priapism; Blood disease, such as multiple myeloma, leukaemia, sickle cell anaemia; Retinitis pigmentosa (a genetic eye disease); Bleeding problems; Stomach ulcers; Liver problems; Severe vision loss; Kidney problems; Any other medical conditions.

Each drug comes with the chance of drug interactions.