Oral semisynthetic aminopenicillin similar to ampicillin; not stable to beta-lactamases of either gram-positive or gram-negative bacteria; more stable to gastric acid than penicillin; more bioavailable than oral ampicillin; commonly used to treat otitis media, bronchitis, sinusitis; also used in combination regimens for H.
Amoxicillin/Amoxicillin Trihydrate/Amoxil Oral Tab Chew: 125mg, 250mg Amoxicillin/Amoxicillin Trihydrate/Amoxil Oral Tab: 500mg, 875mg Amoxicillin/Amoxicillin Trihydrate/Amoxil/Moxilin/Sumox/Trimox Oral Cap: 250mg, 500mg Amoxicillin/Amoxicillin Trihydrate/Amoxil/Moxilin/Sumox/Trimox Oral Pwd F/Recon: 5mL, 125mg, 200mg, 250mg, 400mg Moxatag Oral Tab ER: 775mg. 775 mg PO once daily, given within 1 hour of completing a meal, for 10 days.
The American Heart Association (AHA) recommends amoxicillin extended-release as an alternative to
penicillin V for rheumatic fever prophylaxis. 1 g PO once daily or 500 mg PO twice daily for 10 days. The American Heart Association (AHA) recommends extended-release amoxicillin as an alternative to penicillin V for rheumatic fever prophylaxis. 25 mg/kg/dose (Max: 500 mg/dose) PO twice daily for 10 days is recommended by the Infectious Diseases Society of America (IDSA).
Alternatively, 50 mg/kg/dose PO once daily (Max: 1 g/dose) for 10 days is recommended by The American Heart Association (AHA) as an alternative to penicillin V.
For ear/nose/throat infections in general, the FDA-approved dosage is 20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections. 45 mg/kg/day PO in divided doses every 12 hours is the standard dose for children with uncomplicated disease that is mild to moderate in severity who do not attend daycare and who have not been treated with an antimicrobial agent in the previous 4 weeks.
80 to 90 mg/kg/day PO in divided doses every 12 hours (Max: 2 g/dose) is recommended for children in areas with high rates of S. pneumoniae resistance (more than 10%, including intermediate- and high-level resistance). Children younger than 2 years should be treated with amoxicillin; clavulanic acid, not amoxicillin alone.
500 mg PO every 12 hours or 250 mg PO every 8 hours for mild/moderate infections and 875 mg PO every 12 hours or 500 mg PO every 8 hours for severe infections.
20 mg/kg/day PO in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses every 12 hours (Max: 500 mg/dose) for mild to moderate infections and 40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose) for severe infections.
30 mg/kg/day PO given in divided doses every 12 hours. 500 mg PO every 12 hours or 250 mg PO every 8 hours for mild/moderate infections and 875 mg PO every 12 hours or 500 mg PO every 8 hours for severe infections. 80 to 90 mg/kg/day PO divided every 12 hours is first-line therapy.
Treat all patients younger than 2 years and patients 2 years and older with severe disease for 10 days.
For children 2 to 5 years with mild to moderate disease, a 7-day course is acceptable. For children 6 years and older with mild to moderate disease, a 5- to 7-day course is acceptable. Although the FDA-approved dosage ranges from 20 to 45 mg/kg/day PO depending on the severity of infection (Max:
500 mg/dose for every 8 hour dosing and 875 mg/dose for every 12 hour dosing), these low doses are not clinically recommended for the treatment of otitis media.  80 to 90 mg/kg/day PO divided every 12 hours for 10 days was recommended by experts as first-line therapy in previous guidelines; however, this age group is not addressed in the most current guidelines by the American Academy of Pediatrics (AAP).
Although the FDA-approved dosage ranges from 20 to 45 mg/kg/day depending on the severity of infection, these low doses are not clinically recommended for the treatment of otitis media.
30 mg/kg/day PO divided every 12 hours is the general FDA-approved dosing.
Young infants are less capable of responding to infection, and the clinical manifestations of infection can be subtle. Because of the increased risk for complications of an undiagnosed systemic infection, every young infant presenting with a fever should be carefully evaluated. 500 mg PO every 12 hours or 250 mg PO every 8 hours. 20 mg/kg/day PO given in divided doses every 8 hours (Max: 250 mg/dose) or 25 mg/kg/day PO in divided doses given every 12 hours (Max: 500 mg/dose).
30 mg/kg/day PO given in divided doses every 12 hours.
875 mg PO every 12 hours or 500 mg PO every 8 hours.
40 mg/kg/day PO in divided doses every 8 hours (Max: 500 mg/dose) or 45 mg/kg/day PO in divided doses every 12 hours (Max: 875 mg/dose).
30 mg/kg/day PO given in divided doses every 12 hours. 875 mg PO every 12 hours or 500 mg PO every 8 hours. 45 mg/kg/day PO in divided doses every 12 hours or 40 mg/kg/day PO in divided doses every 8 hours (Max: 1,750 mg/day). 30 mg/kg/day PO in divided doses every 12 hours. 1 g PO every 8 hours for at least 5 days as monotherapy for outpatients without comorbidities or risk factors for MRSA or P.
aeruginosa or as part of combination therapy for HIV-infected outpatients.
Guide treatment duration by clinical stability.  90 mg/kg/day PO in divided doses every 8 to 12 hours (Max: 4 g/day) for 5 to 7 days.  Dividing 90 mg/kg/day into 3 doses/day increases the probability for reaching a clinical and microbiological cure to 90% compared with the same daily dose divided into 2 doses/day (65%) in patients with pneumococcal pneumonia (MIC of 2 mcg/mL).
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