Tablet amoxicillin

For acute infections, 50—100 mg/kg/day PO in 3 to 4 divided doses for 14 days. For chronic carriers, 100 mg/kg/day PO in 3 to 4 divided doses plus probenecid (1 g/day PO for adults or 23 mg/kg/day PO for children) for 6 weeks. 1,000 mg PO twice daily in combination with clarithromycin (500 mg PO twice daily) and lansoprazole (30 mg PO twice daily) for 10 to 14 days is recommended. Clarithromycin-containing regimens are associated with a high eradication rate and less side effects than regimens that include metronidazole.

1,000 mg PO twice daily with clarithromycin (500 mg PO twice daily) and omeprazole (20 mg twice daily) for 10 to 14 days.

For patients with an active ulcer, an additional 14 days of omeprazole (20 mg once daily) is recommended for ulcer healing. According to ACG, any standard dose PPI may be substituted for omeprazole in this regimen.

More effective triple drug regimens are available and recommended.

The original FDA-approved dual regimen consists of amoxicillin 1,000 mg PO and lansoprazole (30 mg PO), each given three times daily for 14 days. Clinical trials showed eradication rates of about 70%, which is substantially lower than that achieved with triple-drug therapy regimens; triple-drug therapy was shown to be more effective than all possible dual therapy combinations.

1,000 mg PO twice daily with metronidazole (500 mg PO twice daily) and omeprazole (20 mg twice daily) for 10 to 14 days. For patients with an active ulcer, an additional 14 days of omeprazole (20 mg once daily) is recommended for ulcer healing.

According to ACG, any standard dose PPI may be substituted for omeprazole in this regimen.

A prospective, open label study evaluated the effectiveness of levofloxacin-based dual (levofloxacin/rabeprazole) and triple (levofloxacin/amoxicillin/rabeprazole) therapy in eradicating H.

Patients (n = 160) were randomized into 4 groups (3 dual and 1 triple therapy regimen).

The dual regimens consisted of levofloxacin 500 mg PO once daily with rabeprazole (20 mg PO once daily) for 5, 7, or 10 days.

The triple regimen included amoxicillin 1,000 mg PO twice daily, levofloxacin (500 mg once daily), and rabeprazole (20 mg once daily) for 7 days.

Triple therapy resulted in a significantly higher eradication rate (more than 90%) than dual therapy at any duration (70% or less). 25 mg/kg/dose PO twice daily (Max: 1 g/dose) with metronidazole (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 1 to 2 weeks. 25 mg/kg/dose PO twice daily (Max: 1 g/dose) with clarithromycin (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 1 to 2 weeks. 25 mg/kg/dose PO twice daily (Max: 1 g/dose) with a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 5 days, followed-up by a PPI plus clarithromycin (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and metronidazole (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) for 5 days.

1 g PO every 8 hours as an alternative for penicillin-susceptible strains for patients who cannot take first-line agents (i.e., ciprofloxacin, doxycycline) or if first-line agents are unavailable. Treat for 7 to 10 days for naturally acquired infection.

For a bioterrorism-related event, treat for a total duration of 60 days. Following initial treatment for severe anthrax infection, amoxicillin as a single agent may also be used as follow-up treatment. 75 mg/kg/day PO divided every 8 hours (Max: 1 g/dose) as an alternative for penicillin-susceptible strains. Treat for 7 to 10 days for naturally acquired infection. For a bioterrorism-related event, continue treatment for 60 days.

As oral follow-up combination therapy after initial IV therapy for severe anthrax (non-CNS infection), use amoxicillin in combination with a protein synthesis inhibitor (i.e., clindamycin, doxycycline, linezolid). Continue therapy to complete a treatment course of at least 14 days; additional prophylaxis to complete an antimicrobial course of up to 60 days may be required. 75 mg/kg/day PO divided every 8 hours as an alternative for penicillin-susceptible strains.

Treat

for

For a bioterrorism-related event, continue treatment for 60 days. As oral follow-up combination therapy after initial IV therapy for severe anthrax (non-CNS infection), use amoxicillin in combination with a protein synthesis inhibitor (i.e., clindamycin, linezolid).

Continue therapy to complete a treatment course of at least 14 days; additional prophylaxis to complete an antimicrobial course of up to 60 days may be required. 50 mg/kg/day PO divided every 12 hours as an alternative for penicillin-susceptible strains. Treat for 7 to 10 days for naturally acquired infection. For a bioterrorism-related event, continue treatment for 60 days.

As

oral

75 mg/kg/day PO divided every 8 hours for 60 days after exposure for penicillin-susceptible strains.

50 mg/kg/day PO divided every 12 hours for 60 days after exposure for penicillin-susceptible strains. 250 mg PO every 8 hours in combination with oral erythromycin for 5 days, following 48 hours of IV therapy.

A 7-day course of therapy with broad-spectrum antibiotics is recommended for pregnant women with preterm PROM who are less than 34 0/7 weeks gestation. Administration of broad-spectrum antibiotics has been shown to prolong pregnancy, reduce maternal and neonatal infections, and reduce gestational age-dependent morbidity.

Women with preterm PROM who are candidates for group B streptococcal (GBS) intrapartum prophylaxis should receive GBS prophylaxis to prevent vertical transmission regardless of earlier treatments.[64408] †Indicates off-label use.

1,750 mg/day PO for most labeled indications; however, doses up to 3 g/day PO have been used off-label. 1,750 mg/day PO for most labeled indications; however, doses up to 3 g/day PO have been used off-label. 1,750 mg/day PO is FDA-approved maximum; however, doses up to 4 g/day PO have been used off-label.

45 mg/kg/day PO is FDA-approved maximum; however, doses up to 100 mg/kg/day PO (Max: 4 g/day) have been used off-label.

4 to 11 months: 45 mg/kg/day PO is FDA-approved maximum; however, doses up to 90 mg/kg/day PO have been used off-label.

1 to 3 months: 30 mg/kg/day PO is FDA-approved maximum; however, doses up to 75 mg/kg/day PO have been used off-label. 30 mg/kg/day PO is FDA-approved maximum; however, doses up to 75 mg/kg/day PO have been used off-label. No dosage adjustment needed; amoxicillin is not appreciably metabolized in the liver and does not undergo biliary secretion. The following dosing recommendations pertain to adults. No specific dosage adjustments for pediatric patients with renal impairment are available at this time; however, dosage intervals should be adjusted.

CrCl 10—30 mL/min: 250—500 mg PO every 12 hours, depending on the severity of the infection. Do not use the 875 mg-tablet strength or the extended-release tablet for dosing.

CrCl 3 months of age because of incompletely developed renal function. Safety and effectiveness of Moxatag extended-release tablets has not been established in neonates, infants, or children. Sounds like 'amox-i-cil-lin' Overview Clinicians Clinicians Dose calculator. Easy-to-read medicine information about amoxicillin – what is it, how to take it safely and possible side effects. Amoxicillin is an antibiotic used to treat different infections caused by bacteria, such as chest infections, dental infections and infections of the throat, ear and sinus. It works by killing or stopping the growth of bacteria (bugs) and gets rid of the infection.

Amoxicillin is sometimes used to get rid of Helicobacter pylori, an infection often found in people with stomach ulcers.

It is not effective against infections caused by viruses. Amoxicillin belongs to a group of antibiotics called penicillins. In New Zealand amoxicillin is available as capsules amoxicillin 500 mg use and liquid and can be given as an injection in the hospital.

The dose of amoxicillin will be different for different people depending on the type of infection and your age.

Adults : the usual dose in adults is 250 or 500 milligrams 3 times a day.

Children : the dose for children will depend on their body weight. Your doctor will advise you how

long

Always take your amoxicillin exactly as your doctor has told you. The pharmacy label on your medicine will tell you how much to take, how often to take it and any special instructions.

Capsules : swallow the capsules with a glass of water or milk.

Measure the right amount using an oral syringe or medicine spoon. Do not use a kitchen spoon as it will not give you the right amount. Read more: Tips on how to give medicines to babies and children. Try to space the doses evenly throughout the day, such as the first thing in the morning, early afternoon and at bedtime. Ideally these times should be at least 4 hours apart. If

you

Do not stop taking it, even if you feel your infection has cleared up.

Have ever had an allergic reaction to a medicine, especially a penicillin antibiotic?

Do you have problems with the way your kidneys work? This includes any medicines you are taking that you can buy without a prescription, as well as herbal and complementary medicines. If so, it’s important that you tell your doctor or pharmacist before you start amoxicillin. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Like all medicines, amoxicillin can cause side effects, although not everyone gets them. Often side effects improve as your body gets used to the new medicine. Amoxicillin may interact with some medicines and herbal supplements, so check with your doctor or pharmacist before starting a moxicillin. If you are taking the contraceptive pill, its effectiveness can be reduced if you have a bout of being sick (vomiting) or diarrhoea that lasts for more than 24 hours.

If this happens, ask your doctor or pharmacist for advice about contraception over the following few days.

The following links have more information on amoxicillin.

New Zealand Formulary Patient Information: References. Amoxicillin New Zealand Formulary Antibiotics – choices for common infections BPAC, NZ, 2017. The Maori Pharmacists’ Association have a free phone line to help answer any questions whanau may have about their medicines. Update: Wockhardt UK Ltd - Amoxicillin Sodium 1g, 250mg and 500mg Powder for Solution for Injection. Based on MHRA’s review of available data, the Commission on Human Medicines’ Paediatric Medicine Expert Advisory Group (PMEAG) has advised that Wockhardt UK’s Amoxicillin Sodium Powder for Solution for Injection can be used with caution in neonates and infants.

Update (August 2020) The advice relating to the drug alerts EL (14)A/09 and EL(15)A/11 has been updated.

Please see details below; for reference the original alert details are still listed below. In 2014, a Class 4 Drug Alert asked healthcare professionals not to use Wockhardt UK’s Amoxicillin Sodium Powder for Solution for Injection (all strengths and all batches) in neonates and infants (below 1 year old) following reports of extravasation and injections site reactions; batches of the 500mg product were subsequently recalled. Although no root cause has been confirmed for these events, an investigation identified contributing factors, which are currently considered to be resolved.

Based on MHRA’s review of available data, the Commission on Human Medicines’ Paediatric Medicine Expert Advisory Group (PMEAG) has advised that Wockhardt UK’s Amoxicillin Sodium Powder for Solution for Injection can be used with caution in neonates and infants.

Healthcare professionals are asked to exercise caution when using these products and monitor the cannula site before, during and after administration; administration should be stopped immediately if extravasation or injection site reactions are suspected and local guidelines followed.