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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

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For acute infections, 50—100 mg/kg/day PO in 3 to 4 divided doses for 14 days.

For chronic carriers, 100 mg/kg/day PO in 3 to 4 divided doses plus probenecid (1 g/day PO for adults or 23 mg/kg/day PO for children) for 6 weeks. 1,000 mg PO twice daily in combination with clarithromycin (500 mg PO twice daily) and lansoprazole (30 mg PO twice daily) for 10 to 14 days is recommended. Clarithromycin-containing regimens are associated with a high eradication rate and less side effects than regimens that include metronidazole.

1,000 mg PO twice daily with clarithromycin (500 mg PO twice daily) and omeprazole (20 mg twice daily) for 10 to 14 days.

For patients with an active ulcer, an additional 14 days of omeprazole (20 mg once daily) is recommended for ulcer healing. According to ACG, any standard dose PPI may be substituted for omeprazole in this regimen.

More effective triple drug regimens are available and recommended.

The original FDA-approved dual regimen consists of amoxicillin 1,000 mg PO and lansoprazole (30 mg PO), each given three times daily antibiotics after tooth extraction amoxicillin for 14 days. Clinical trials 1000 mg amoxicillin for chlamydia showed eradication rates of about 70%, which is substantially lower than that achieved with triple-drug therapy regimens; triple-drug therapy was shown to be more effective than all possible dual therapy combinations.

1,000 mg PO twice daily with metronidazole (500 mg PO twice daily) and omeprazole (20 mg twice daily) for 10 to 14 days.

For patients with an active ulcer, an pms amoxicillin additional 14 days of omeprazole (20 mg once daily) is recommended for ulcer healing.

According to ACG, any standard dose PPI may be substituted for omeprazole in this regimen.

A prospective, open label study evaluated the effectiveness of levofloxacin-based dual (levofloxacin/rabeprazole) and triple (levofloxacin/amoxicillin/rabeprazole) therapy in eradicating H. Patients (n = 160) were randomized into 4 groups (3 dual and 1 triple therapy regimen).

The dual regimens consisted of levofloxacin 500 mg PO once daily with rabeprazole (20 mg PO once daily) for 5, 7, or 10 days.

The

triple regimen included amoxicillin 1,000 mg PO twice daily, levofloxacin (500 mg once daily), and rabeprazole (20 mg once daily) for 7 days. Triple therapy resulted in a significantly higher eradication rate (more than 90%) than dual therapy at any duration (70% or less).

25 mg/kg/dose PO twice daily (Max: 1 g/dose) with metronidazole (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 1 to 2 weeks.

25 mg/kg/dose PO twice daily (Max: 1 g/dose) with clarithromycin (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 1 to 2 weeks. 25 mg/kg/dose PO twice daily (Max: 1 g/dose) with a proton pump inhibitor (PPI; 1 to 2 mg/kg/day PO divided every 12 hours [Max: 20 mg/dose]) for 5 days, followed-up by a PPI plus clarithromycin (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) and metronidazole (10 mg/kg/dose PO twice daily [Max: 500 mg/dose]) for 5 days.

1 amoxil for tooth infection g PO every 8 hours as an alternative for penicillin-susceptible strains for patients who cannot take first-line agents (i.e., ciprofloxacin, doxycycline) or if first-line agents are unavailable.

Treat for 7 to 10 days for naturally acquired infection.

For a bioterrorism-related event, treat for a total duration of 60 days. Following initial treatment for severe anthrax infection, amoxicillin as a single agent may also be used as follow-up treatment.

75 mg/kg/day PO divided every 8 hours (Max: 1 g/dose) as an alternative for penicillin-susceptible strains. Treat for 7 to 10 days for naturally acquired infection. For a bioterrorism-related event, continue treatment for 60 days.

As oral follow-up combination therapy after initial IV therapy for severe anthrax (non-CNS infection), use amoxicillin in combination with a protein synthesis inhibitor (i.e., clindamycin, doxycycline, linezolid). Continue therapy to complete a treatment course of at least 14 days; additional prophylaxis to complete an antimicrobial course of up to 60 days may be required. 75 mg/kg/day PO divided every 8 hours as an alternative for penicillin-susceptible strains.

Treat for 7 to 10 days for naturally acquired infection. For a bioterrorism-related event, continue treatment for 60 days.

As oral follow-up combination therapy after initial IV therapy for severe anthrax (non-CNS infection), use amoxicillin in combination with a protein synthesis inhibitor (i.e., clindamycin, linezolid).

Continue therapy to complete a treatment course of at least 14 days; additional prophylaxis to complete an antimicrobial course of up to 60 days may be required. 50 mg/kg/day PO divided every 12 hours as an alternative for penicillin-susceptible strains. Treat for 7 to 10 days for naturally acquired infection.

For a bioterrorism-related event, continue treatment for 60 days. As oral follow-up combination therapy after initial IV therapy for severe anthrax (non-CNS infection), use amoxicillin in combination with a protein synthesis inhibitor (i.e., clindamycin, linezolid).



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