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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

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Especially tell your doctor if you take: birth control pills probenecid (Benemid) warfarin (Coumadin, Jantoven) other antibiotics such as chloramphenicol, erythromycin, clarithromycin, azithromycin, doxycylcine, minocycline, tetracycline, or "sulfa drugs" This is not a complete list of amoxicillin drug interactions.

Ask your doctor or pharmacist for more information.

Serious side effects have been reported with amoxicillin including the following: Hypersensitivity (allergic) reactions.

Tell your doctor if you are allergic to amoxicillin, penicillin, cephalosporins, or any other medication.

Do not take amoxicillin if you have a penicillin allergy. Serious allergic reactions, including anaphylaxis (life-threatening), have occurred in patients taking penicillin antibiotics. Signs of an

allergic

reaction include: rash hives itching swelling of the face, lips, mouth, or throat difficulty breathing Diarrhea . Diarrhea is a common problem caused by antibiotics. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as 2 or more months after the last dose.

If diarrhea is severe, lasts more than 2 or 3 days, and is accompanied by fever, contact your doctor, as this may be a sign of an infection of the bowels. Amoxicillin chewable tablets contain phenylalanine. Caution is advised for those who have phenylketonuria. Do not take amoxicillin if you: have mononucleosis.

A high percentage of patients with mononucleosis who receive ampicillin develop a skin rash. have a history of allergic reaction to any type of penicillin antibiotic, including amoxicillin.

In some cases, this may be harmful and your doctor may advise you to avoid certain foods.

In the case of amoxicillin there are no specific foods that you must exclude from your diet when receiving amoxicillin. Before taking amoxicillin, tell your doctor about all of your medical conditions.

Especially tell your doctor if you: are allergic to penicillin or any other medications develop watery and bloody stools (with or without stomach cramps and fever) 2 or more months after having taken the last dose of the antibiotic.

This is not typical, and your doctor should be notified.

have a history of diarrhea caused by taking antibiotics have phenylketonuria have kidney disease have asthma have hay fever are pregnant or breastfeeding. Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy.

Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

There are no well-done studies that have been done in humans with amoxicillin.

But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication. Tell your doctor if you are breastfeeding or plan to breastfeed. Amoxicillin has been detected in

human

breast milk.

Because of the possibility for adverse reactions in nursing infants from amoxicillin, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Amoxicillin comes as a capsule, tablet, and oral suspension forms. This medication is taken up to 3 times daily, with or without food.

Thoroughly crush or chew and swallow the chewable tablets.

Do not chew, divide, or break regular amoxicillin tablets and capsules.

If you miss a dose, take the missed dose as soon as you remember.

If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time.

Do not take two doses of amoxicillin at the same time.

Take Amoxicillin exactly as prescribed by your doctor.

Follow the directions on your prescription label carefully. The Amoxicillin dose your doctor recommends will be based on the following: the condition being treated other

medical

conditions you have other medications you are taking how you respond to this medication your weight your height your age your gender. Neonates and Infants aged 12 weeks or younger (? 3 months): the recommended upper dose of amoxicillin is 30 mg/kg/day divided and given twice daily.

Adult Dosing (or children 40kg/88 lbs or greater): Ear/Nose/Throat infection, mild or moderate: 500 mg twice daily or 250 mg three times daily Ear/Nose/Throat, severe infection: 875 mg twice daily or 500 mg three times daily Lower respiratory tract (airway) infection, mild or moderate or severe: 875 mg twice daily or 500 mg three times daily Skin/Skin Structure infection, mild or moderate: 500 mg twice daily or 250 mg three times Skin/Skin Structure infection, severe: 875 mg twice daily or 500 mg three times daily Genitourinary tract infection, mild or moderate: 500 mg twice daily or 250 mg three times daily Genitourinary tract infection, severe: 875 mg twice daily or 500 mg three times daily Gonorrhea Acute, uncomplicated ano-genital and urethral infections in males and females: 3 grams as single oral dose.

Dosing in Children (greater than 3 months old or less than 40 kg/88 lbs): Ear/Nose/Throat infection, mild or moderate: hours 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours Ear/Nose/Throat, severe infection: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours Lower respiratory tract (airway) infection, mild or moderate or severe: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours Skin/Skin Structure infection, mild or moderate: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours Skin/Skin Structure infection, severe: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours Genitourinary tract infection, mild or moderate: 25 mg/kg/day in divided doses every 12 hours or 20 mg/kg/day in divided doses every 8 hours Genitourinary tract infection, severe: 45 mg/kg/day in divided doses every 12 hours or 40 mg/kg/day in divided doses every 8 hours Gonorrhea Acute, uncomplicated ano-genital and urethral infections in males and females: Prepubertal children: 50 mg/kg amoxicillin, combined with 25 mg/kg probenecid as a single dose. SINCE PROBENECID IS CONTRAINDICATED IN CHILDREN UNDER 2 YEARS, DO NOT USE THIS REGIMEN IN THESE CASES. If you take too much amoxicillin, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. Abclox Abimox-DC ACL Aclowell-L Acmox Acmox TAB Acmox-DS Actimox Adcil Adclox-D Afymox-DT

Afymox-DX

Agmox Agmox-DX Agmox-LB Alclox-D Aldico Alexi-DX Allmox Allmox INJ Allmox SYR Alnaclox Alnaclox-KID Alnaclox-LB Alnaclox-LB KID Alnamox Amclosym Amclox-DL Amdiclox Amex-D Amimox Amimox-DX Amo-DX Amoclox-D Amolac 250 Amolac 500 Amosis Amosis-DCL Amosym Amotex Amotex-D Amox Amox-AR Amox-DT Amox-LB Amoxil Amoxinga Amoxinga SYR Amoxipen Amoxivan. P - Caution when used during pregnancy L - Caution when used during lactation. Amoxicillin abbreviated AMOX, is a moderate-spectrum, bacteriolytic, ?-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.

It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other ?-lactam antibiotics.

Amoxicillin is susceptible to degradation by ?-lactamase-producing bacteria, and so may be given with clavulanic acid to decrease its susceptibility. Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis. Absorption Rapidly and completely absorbed from the GI tract with peak plasma concentrations after 1-2 hours (oral).

Not inactivated by gastric acid and presence of food does not impair absorption.

Distribution Widely distributed, CSF (small concentrations except when the meninges are inflamed), bile (high concentrations); crosses the placenta and enters the breast milk (small amounts). Metabolism Converted to a limited extent to penicilloic acid.

Excretion Via the urine within 6 hours by glomerular filtration and tubular secretion (as penicilloic acid and 60% unchanged drug); via the faeces.

May be removed by haemodialysis; 1-1.5 hours (elimination half-life). Amoxicillin Adverse Reactions / Amoxicillin Side Effects. Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis. Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis. Monitor Periodically assess renal, hepatic, and hematopoietic function during prolonged therapy. Patients diagnosed with gonorrhea should have a serologic test for syphilis at the time of treatment and a follow-up serologic test after 3 months. In

the

treatment of UTI, frequent bacteriological and clinical appraisals are necessary.

Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis. Decreased effects with tetracyclines and chloramphenicol.

Potentially Fatal: Increase effects of oral anticoagulants. Oral Endocarditis Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours. Child: ?10 years: 125-250 mg every 8 hours; Oral Biliary tract infections Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours; Oral Gonorrhoea Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours: Oral Otitis media Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours Child: ?10 years: 125-250 mg every 8 hours; Oral Pneumonia Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years 125-250 mg every 8 hours; Oral Urinary tract infections Adult: 250-500 mg every 8 hr or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours; Oral Mouth infections Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours. Child: ?10 years: 125-250 mg every 8 hours; Oral Spleen disorders Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours. Child: ?10 years: 125-250 mg every 8 hours; Oral Actinomycosis Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours. Child: ?10 years: 125-250 mg every 8 hours; Oral Bronchitis Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours; Oral Typhoid and paratyphoid fever Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours; Oral Gastroenteritis Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours.

Child: ?10 years: 125-250 mg every 8 hours; Oral Lyme disease Adult: 250-500 mg every 8 hours or 500-875 mg every 12 hours. Child: ?10 years: 125-250 mg every 8 hours; Oral Uncomplicated gonorrhoea Adult: 3 g as a single dose with probenecid 1 g. Renal impairment: Patients on haemodialysis should receive 250-500 mg every 24 hours and an additional dose during and after each dialysis session.

CrCl (ml/min) Dosage Recommendation 10-30 250-500 mg every 12 hours.



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