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Patients were then reviewed three months after the last SRP visit and the clinical measurements were repeated. All clinical measurements and treatment were performed by one clinician (AS). The intra?class correlation (ICC) for the PPD was 0.896. Also, the reproducibility of the measurements between ?1 and +1 mm was 94%. The primary outcome variable was the change in CAL between baseline and 3 months. The secondary outcome variables included the changes in PPD, FMBS, FMPS and the number of shallow, moderate and deep sites. Four different analyses were carried out: all sites analysis; molar only analysis; breakdown analysis of baseline PPDs categories; analysis of the number of sites with different PPD categories. Within each treatment group, the significance of differences over time (baseline – three months) for the mean PPD, mean CAL, the FMBS and the FMPS was sought using paired t ?test. The difference between the treatment groups at three months was assessed using the Tukey multiple comparisons of means test. Molar plaque score (MPS) and molar bleeding score (MBS) were calculated instead of FMPS and FMBS. Sites were subset according to the baseline PPD into three categories: shallow (1–3 mm), moderate (4–6 mm) and deep (>6 mm). For each category, changes in PPD and CAL from baseline to three months within the treatment groups were determined (paired t ?test). A comparison was also carried out between the treatment groups at three months for each category (using Tukey multiple comparisons of means test). Analysis of the number of sites with different PPD categories. It is suggested that the efficacy endpoints in periodontal therapy should be evaluated in terms of the number of sites with persistent pocketing (>4 mm) rather than changes in mean PPD and CAL. 17 Therefore, the mean number of sites with PPD 1–3 mm, 4–6 mm and >6 mm were also calculated in each treatment group at baseline and at three months. Paired t ?test was performed to show amoxicillin 1000 mg price whether a significant change in the number of shallow, moderate and deep sites has occurred for each treatment group. The mean number of shallow, moderate and deep sites at three months was also compared between the treatment groups using the ANOVA test. Finally, the magnitude of change in the mean number of sites for each PPD categories (number of sites at baseline minus number of sites at review) was compared between the treatment groups. The rationale of this analysis is outlined in the Discussion section. This comparison was performed using the Tukey's post hoc comparison test. For all of the above analysis, a difference was considered significant if the level of statistical significance was p. Subject retention, medication compliance and adverse effects. Figure 1 represents the flowchart of the study design. Thirty?seven patients entered the study at baseline and completed the initial phase of treatment. They were randomly allocated into three groups: SRP group (n = 12); A+M group (n = 13); and Az group (n = 12). All patients completed the checklist to confirm compliance of the medication regimen. At review, five subjects were eliminated due to lack of compliance with the regimen. One out of the four did not complete the amoxicillin 650 mg course of medication due to developing gastro?intestinal disturbance, nausea and vomiting. The other four did not comply for other reasons not related to adverse effects of the medication. Hence, the sample size was reduced to 32 patients, all of which had completed the described regimen: SRP group (n = 10); A+M group (n = 11); and Az group (n = 11). Dropped out patients were not included in the comparative statistical analysis. In the A+M group, two patients reported stomach upset and nausea, one patient experienced diarrhoea during the intake of the drugs and two patients had both stomach upset together with diarrhoea. In other words, 5 out of the 11 patients experienced at least one adverse effect amoxicillin walmart over the counter of A+M. In the Az group, 4 out of the 11 patients reported an adverse effect. Two stated having stomach upset, one experienced diarrhoea and one experienced an increased frequency of urination.
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