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However, the significance of this link is still unclear.

Viagra is an oral medication used to treat erectile dysfunction (ED) in men.

An erection occurs when blood flow increases into the penis, making it expand and become firm.

Two long chambers inside the penis called the corpora cavernosa contain spongy tissue that collects blood flowing into the chambers, creating pressure that results in the expansion of the penis. Viagra, as a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), works to block certain naturally occurring enzymes in the body, causing blood vessels to relax and enhancing blood flow to the penis.

Viagra does not automatically cause an erection; rather, it assists a man with ED in obtaining and keeping an erection

when

sexually aroused or stimulated.

Sildenafil for Pulmonary Arterial Hypertension (PAH) The active ingredient in Viagra can treat other disorders. Revatio (sildenafil) is prescribed for adults with pulmonary arterial hypertension (PAH).

PAH is a progressive, life-threatening disorder that causes abnormally high blood pressure in the pulmonary artery, which is the blood vessel responsible for carrying blood from the heart to the lungs.

Revatio works to improve a patient’s ability to exercise and slow down the progression and worsening of the disease. Signs and symptoms of this serious health condition can include shortness of breath when active, fainting spells, dizziness, swelling of the

ankles

or legs, chest pain, and a rapid heart rate.

The National Institutes of Health (NIH) defines erectile dysfunction as “a condition in which a man is unable to get or keep an erection firm enough for sexual intercourse.” Signs of erectile dysfunction (ED), sometimes referred to as impotence, may include the ability to get an erection sometimes but not every time, the ability to get an erection that does not last long enough to engage in sexual intercourse, or the inability to get an erection at any time.

Physical causes for the condition can include nerve damage, artery damage, or damage to the smooth muscles and fibrous tissues in the penis. Certain diseases and health complications can also lead to ED, such as high blood pressure and diabetes. Psychological and emotional disorders, such as anxiety, depression and stress, as well as certain lifestyle choices, such as an unhealthy diet, lack of exercise, drinking in excess and smoking, can cause or exacerbate ED. ED can also be a potential side effect when taking certain medications, including those used to treat blood pressure, allergies, depression and ulcers.

Complications of the condition can result in an unfulfilled sex life, emotional problems, such as depression and anxiety, a loss of intimacy with a partner and/or a strained relationship, and the inability to get a partner pregnant. Viagra is taken by mouth as prescribed and as needed for erectile dysfunction (ED).

Viagra should not be taken more than once a day, or more than once every 24 hours. It is supplied as a blue, film-coated, rounded-diamond-shaped tablet. It comes in three different strengths, including 25, 50 and 100 milligrams.

The dose can be adjusted as needed for effectiveness and tolerability. Viagra may be taken anywhere from 30 minutes to four hours before engaging in sexual intercourse.

However, if Viagra is taken with a high-fat meal, it will take longer for its effects to work.

Sildenafil taken in the form of Revatio is a liquid administered orally with a syringe. The recommended dose of Revatio is five or 20 milligrams taken three times a day about four to six hours apart.

Revatio injections are also available for the continued treatment of patients with PAH who are prescribed the medication in an oral form but are temporarily unable to take oral medications. These can include an erection that will not go away (priapism), sudden vision loss in one or both eyes, and sudden hearing decrease or hearing loss.

Some

men

have also experienced heart attack, stroke, irregular heartbeats and even death after taking Viagra.

Most, but not all, of these men were

found

to have had heart problems prior to taking Viagra.

It is unknown if Viagra caused or exacerbated these problems.

Headache Flushing (feeling of warmth) Upset stomach Muscle pain Nausea Dizziness Abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision Stuffy or runny nose Back pain Rash.

Other side

effects

associated with the use of sildenafil may include diarrhea, heartburn, difficulty viagra pill price falling asleep or staying asleep, numbness, burning or tingling in the arms, hands, feet or legs, nosebleeds, and sensitivity to light.

Viagra and Melanoma (Skin Cancer) In 2014, a study published in JAMA Internal Medicine found that men who used Viagra were 84 percent more likely to develop melanoma, the most dangerous form of skin cancer, over a period of 10 years. However, former executive editor of Harvard Men’s viagra pill price Health Watch, Daniel Pendick, said that this study merely showed a connection between men taking Viagra and the later diagnosis of melanoma, and not that Viagra is a definitive cause of the development of skin cancer.

Hensin Tsao of Massachusetts General Hospital, who is considered an expert in melanoma and skin cancer risk, shared his thoughts with Harvard Health Publications, stating that the study “warrants more careful replication” and that “several factors need to be considered.” However, the 2014 JAMA publication also describes a biological response to sildenafil (the active ingredient in Viagra) that acts to increase the invasiveness of melanoma cells. Accordingly, the study concluded that this may be associated with a heightened risk of the development of melanoma in patients using sildenafil. While the study authors stated that the data from their study was “insufficient to alter clinical recommendations,” they also noted the

importance

of continued investigation. A few follow-up studies have been performed to look at the potential viagra pill price risk for melanoma a little more closely. Some of these studies found an increased risk of melanoma among patients who used Viagra (or other similar drugs), but other studies did not find a significant connection between Viagra use and melanoma, and none of these studies showed that Viagra is a true cause of melanoma. FDA Safety Communication: Revatio (sildenafil) In 2012, the U.S.

Food and Drug Administration (FDA) advised that Revatio (sildenafil) should not be prescribed to children ages 1 through 17 for pulmonary arterial hypertension (PAH), or high blood pressure in the blood vessels leading to the lungs.

This recommendation came after a long-term pediatric clinical trial that showed that children taking a high dose of Revatio had a higher risk of death than children taking low doses, and that the lower doses of Revatio were not effective in improving exercise ability in children. The FDA found that most of the deaths that occurred in children taking Revatio were caused by pulmonary hypertension, a broader health condition including PAH, and heart failure.

These are among the most common causes of death in children with PAH. Revatio was never approved by the federal agency for use in children, and following the new information from the clinical trial, off-label use (or use

not

indicated or approved by the

FDA

) of the drug in pediatric patients was discouraged.

These findings were therefore required by the FDA to be added to a new drug label for Revatio.

In 2014, the FDA issued an update and clarification of its earlier recommendation.

The FDA stated that the purpose of its prior communication was simply to raise awareness as to the higher risk of death in pediatric patients, but the recommendation “was not intended to suggest that Revatio should never be used in children.” The FDA concluded that it was up to health care professionals to consider whether the benefits of treatment are likely to outweigh the potential risks to their patients. The federal agency confirmed that while the evidence behind its initial recommendation had not changed, the 2014 update was more of a clarification as to the “strength of the warning” included on the Revatio drug label.

Certain drug interactions can occur when taking Viagra along with other medications.

These interactions can act to either lessen or increase the effects of Viagra, and can cause unexpected side effects. Cimetidine (brand name Tagamet), classified as a nonspecific CYP inhibitor used to inhibit stomach acid production, has been shown to increase the concentration of sildenafil in patients’ blood. CYP3A4 inhibitors, when taken in conjunction with Viagra, have also been shown to increase viagra pill price blood concentration levels of sildenafil. The HIV drug ritonavir, when taken with Viagra, resulted in a four-fold increase in the amount of sildenafil present in patients’ blood in clinical studies.

This necessitated a recommended dosing adjustment in patients taking Viagra while also being treated with ritonavir.

Patients taking both medications should not take

Viagra

more often than every 48 hours. Take 50 mg of Viagra one hour before you are ready to engage in sexual activity. Viagra works best 30 minutes to four hours after taking the pill. If you do not achieve an erection with sexual stimulation, you can increase the dosage of your medication the next time sexual activity is planned. After surgery, most men require doses of 100 mg, or more, of Viagra.

Within eight to 12 hours, Viagra is almost completely eliminated from the body. Take 10 mg of Levitra 30 minutes to one hour before you are ready to engage in sexual activity.

Levitra works best 30 minutes to four hours after taking the pill. If you do not achieve an erection, you may need to increase the dosage. Take 10 mg of Cialis at least two hours before you are ready to engage in sexual activity. Cialis can be taken on a full stomach following meals and the effect of medication may last up to 36 hours. If you do not achieve an erection on 10 mg, higher dosages can be taken, though you must consult your doctor regarding higher doses. The most common side effects of oral medications for erectile dysfunction include headache, facial flushing and upset stomach.

A small number of patients taking Viagra or Levitra may complain of a "blue cast" to their vision, sensitivity to light or blurred vision. However, back pain and joint aches can occur with Cialis.

Although Viagra, Levitra and Cialis have been shown to be effective in many men with erectile dysfunction, they are not effective in patients who have a prostatectomy, unless a nerve-sparing approach was used. These medications must not be used with medications containing nitrate,

such

as nitroglycerin, Nitrostat, Nitro-Bid, Nitro-Dur, Isordil and Ismo, or Deponit. UCSF Health medical specialists have reviewed this information.

It is for educational purposes only

and

is not intended to replace the advice of your doctor or other health care provider.

We encourage you to discuss any questions or concerns you may have with your provider. Roach: Viagra and Cialis usually

safe

for those with heart disease.

Roach: I am an 80-year-old man who still has psychological drive, but who has lost the physical ability for an erection.

I have had multiple bypass surgeries, so I am fearful of medicines like Viagra or Cialis, but I wonder about pills like viagra at cvs the safety of testosterone. Dear F.E.D: Although older men often have decreasing ability for an erection, finding out

the

underlying cause is important before trying medications.

In men with a known

history

of blockages in the artery — whether in the heart (leading to a stent or bypass), brain (leading to stroke or TIA) or elsewhere in the body (claudication, painful calf muscles with walking is a common symptom) — it is worth considering whether the arteries that supply the penis with blood flow might also be blocked.

In men without known blockages, erectile dysfunction is a clue that there might be arterial disease and should always be considered.

Treatment with sildenafil (Viagra) or similar drugs is usually safe in people with heart disease; however, these drugs may not be used by men who take nitroglycerine or related drugs.

It’s usually not enough to cause problems, but your heart doctor can tell you whether it is safe for you.

Testosterone is used only in men with signs and symptoms of low testosterone and at least two documented low blood levels, ideally with tests taken at 8 a.m.

Roach: What’s the difference between smoking tobacco, marijuana or clove to our body?

Dear I.F.: Just because a substance is a plant or plant-derived does not mean it is safe.

Tobacco contains nicotine, a habit-forming and moderately toxic chemical.

It causes dramatic increase in the risk of heart disease and cancer, and smoking kills approximately 500,000 people per year in the U.S. Cannabis contains, among other

substances

, the psychoactive chemical THC, which causes a euphoria (”high”) in most people.

This can cause poor judgment, especially at higher doses, and it increases driving risk. There is good evidence that cannabis, when used by teenagers, causes an increased risk for schizophrenia.

However, the number of deaths due to cannabis is very low.

Proponents say it’s zero, but there are certainly case reports of deaths linked to cannabis use. But that number is extremely small compared with tobacco. Clove cigarettes are usually made with tobacco as well, so they have

the

same risk as regular tobacco cigarettes. Smoking any substance can cause damage to the lungs, potentially leading to chronic lung disease. These are less likely in cannabis smokers, as they tend to smoke much less than tobacco smokers. Cannabis extracts may also be ingested, rather than smoked, negating that viagra pill price risk.

Many states are in the process of legalizing cannabis for medical and recreational use. In the U.S., federal law continues to view cannabis and its extracts as illegal substances, although the U.S. government has generally not been enforcing the law in recent years.



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