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At the present time, there are no specific antidotes to PDE5 inhibition. Interaction With Common Antihypertensive Agents Other Than ?-Blockers. Several studies investigated the interactions of sildenafil, vardenafil, and tadalafil on blood pressure in patients already taking usual antihypertensive medicines, such as calcium channel blockers, diuretics, ?-blockers, angiotensin-converting-enzyme inhibitors, and angiotensin receptor blockers. In general, these studies suggested that when a PDE5 inhibitor was administered to patients already taking antihypertensive medications, small additive drops in blood pressure occurred that were roughly equivalent to or less than the drops in pressure that occurred when the PDE5 inhibitors were taken without concomitant antihypertensive agents. Webb et al 25 studied men who were already receiving amlodipine for the treatment of hypertension for at least 1 month. These authors showed that 100 mg sildenafil given 2 hours after a morning dose of 5 or 10 mg amlodipine resulted in a mean maximal change from baseline blood pressure of ?8 mm Hg supine systolic and ?7 mm Hg supine diastolic compared with men who received placebo plus amlodipine. The differences in standing systolic and diastolic blood pressures were ?10 and ?8 mm Hg, respectively. Even smaller additional reductions in blood pressure were reported when the PDE5 inhibitor sildenafil was administered to patients already taking ?-blockers, diuretics, or angiotensin-converting-enzyme inhibitors. 30 There was sildenafil 200 mg online no increase in adverse events in patients treated with sildenafil who received antihypertensive medicines, even multiple antihypertensive medicines. 30–32 No increase in syncope or postural hypotension was reported when sildenafil was given to patients already taking these common antihypertensive drugs. Furthermore, the most common side effects of sildenafil (headache, flushing, dyspepsia, visual disturbance, rhinitis) were not worsened in patients on concomitant antihypertensive medicines, even if the patients were taking 2 or more antihypertensive medicines. 31 The efficacy of sildenafil to improve ED remained high (?72%) in hypertensive patients taking antihypertensive agents. Vardenafil was associated with a small or no fall in blood pressure when administered to patients taking their usual antihypertensive medicines. 33,34 Vardenafil 20 mg produced an additional fall in mean systolic/diastolic blood pressure of 6/5 mm Hg versus placebo when it was concomitantly administered with slow-release nifedipine (30 or 60 mg) in patients whose blood pressure had been controlled with this calcium channel blocker. Kloner et al 36 reported a series of studies in which 10 or 20 mg tadalafil was administered to patients with hypertension taking antihypertensive medications or to healthy individuals who received an antihypertensive medicine. In healthy individuals receiving 5 mg amlodipine daily for at least 14 days, 20 mg tadalafil had no significant additional effect with a mean change in systolic/diastolic blood pressure of ?1/1 mm Hg compared with placebo. This viagra for female buy online ambulatory blood pressure monitoring study showed no interaction between 5 mg amlodipine and 20 mg tadalafil. Tadalafil 10 mg given to hypertensive patients who had been receiving the thiazide diuretic bendrofluazide was associated with an additional reduction in supine systolic/diastolic blood pressure of 6/4 mm Hg and in standing systolic/diastolic pressure of the same degree. Tadalafil 10 mg administered to patients taking metoprolol (25 to 200 mg daily) resulted in an additional mean reduction in supine systolic/diastolic blood pressure of 5/3 mm Hg and in standing systolic/diastolic blood pressure of 7/4 mm Hg. Tadalafil 10 mg administered to patients taking enalapril (10 to 20 mg per day) was associated with a mean reduction in supine systolic/diastolic blood pressure of 4/1 mm Hg and in standing systolic/diastolic blood pressure of 3/1 mm Hg. In an ambulatory BP monitoring study, 20 mg tadalafil given to patients already receiving various angiotensin receptor blockers was associated with an additional mean reduction in ambulatory systolic/diastolic blood pressure of 8/4 mm Hg. The incidence of adverse events in tadalafil-treated patients in general was similar to that in patients receiving or not receiving concomitant antihypertensive medicines, similar to observations with the other PDE5 inhibitors. In general, sildenafil, vardenafil, and tadalafil appear to be well tolerated and safe in patients receiving most concomitant antihypertensive agents. There appears to be no or only small additive drops in blood pressure that occur when the PDE5 inhibitor is administered in addition to the antihypertensive medicines. The 1 exception to this appears to be ?-blockers, cheap viagra pills for sale as described next. There were recent changes to the labeling of sildenafil regarding concomitant use in patients receiving ?-blockers. 37 One study assessed concomitant administration of the nonselective ? 1 -blocker doxazosin with sildenafil in patients with benign prostatic hypertrophy who had been taking ?-blockers for at least 8 weeks. Doxazosin is given for both hypertension and benign prostatic hypertrophy. Two of 20 patients receiving 4 mg doxazosin and 50 mg sildenafil developed symptomatic hypotension. Interestingly, no (0/20) patients receiving 4 mg doxazosin and 100 mg sildenafil had symptomatic hypotension. Also, the 25-mg dose of sildenafil, when coadministered with 4 mg doxazosin, was not associated with hypotension. The label precaution (not contraindication) now advises that 50 or 100 mg sildenafil should not be taken within a 4-hour window of ?-blocker administration. A 25-mg dose of sildenafil may be taken at any time in relation to an ?-blocker. Tadalafil is contraindicated in patients taking ?-blockers except for 0.4 mg tamsulosin (? 1a -blocker). In 1 study, 39 20 mg tadalafil augmented the hypotensive effect of 8 mg doxazosin with a mean maximal decrease in standing systolic blood pressure that was greater than placebo (mean difference of 9.8 mm Hg). The number of subjects with a standing systolic blood pressure of 39 0.4 mg tamsulosin was given with 10 or 20 mg tadalafil. In subjects taking this ?-blocker, tadalafil produced mean maximal reductions in standing systolic blood pressure that were similar to those seen with placebo (mean difference of 1.7 mm Hg with 10 mg tadalafil and of 2.3 mm Hg with 20 mg tadalafil). Furthermore, none of the subjects receiving tamsulosin plus tadalafil dropped their standing systolic blood pressure to 19,40 and carries the label warning that it should be avoided in patients with congenital QT prolongation and patients taking class IA (eg, quinidine, procainamide) or class III (eg, amiodarone, sotalol) antiarrhythmic medications. Tadalafil 20,41 and sildenafil 37 do not carry this statement. To date, there have been no known cases of torsade de pointes in patients receiving PDE5 inhibitors. In our experimental animal studies of acute coronary artery occlusion, administration of sildenafil was not associated with an increase in ventricular arrhythmia. 42 Additional details on QT interval may be found in the online supplement to this article. Studies with sildenafil, vardenafil, and tadalafil showed that when these agents were given to patients with coronary artery disease during exercise stress testing, there was no exacerbation of ischemia compared with placebo. 43–46 A very important aspect of these studies was that the level of exercise was similar to or exceeded that achieved during sexual intercourse. In a few of these studies, sildenafil 43 and vardenafil 45 actually appeared to have a beneficial effect on exercise-induced ischemia. A study performed in the cardiac catheterization laboratory by Hermann et al 14 observed that when oral sildenafil was administered to patients with severe coronary artery disease, it had no adverse effects on coronary artery diameter or coronary artery flow velocity and actually improved coronary artery vasodilator reserve induced by adenosine. Halcox et al 47 demonstrated a slight vasodilating effect of sildenafil on epicardial coronary arteries. The effects of vardenafil and tadalafil on coronary artery hemodynamics are unknown at this time. Do PDE5 Inhibitors Cause Myocardial Infarction or Death? After the initial release of sildenafil, there were anecdotal reports of myocardial infarction and death. However, sexual activity itself may be associated with a small but definite increase in risk of myocardial infarction. 48 Patients with ED are more likely to have risk factors for coronary artery disease (such as age ?45, smoking, lipid abnormalities, diabetes, hypertension, and lack of physical activity) or have frank heart disease. 6–8,49 Analysis of double-blind, randomized, controlled studies and open-label studies did not show an increase in the rates of myocardial infarction or death in patients receiving sildenafil versus placebo or when compared with age-matched expected events. 2,50–55 Similar results have been reported with tadalafil 20,21 and vardenafil. 56 Postmarketing surveys in the United Kingdom 54 and in the United States, including 1 by the FDA, 52 did not show a rate of myocardial infarction, ischemic heart disease, or mortality in men who took sildenafil to be greater than expected than in an age-matched population. In fact, death rates tended to be less in the population taking sildenafil (perhaps suggesting that healthier men were receiving the drug). Postmarketing data regarding cardiovascular event rates in men taking vardenafil or tadalafil have yet to be reported and will be important. PDE5 inhibitors have potential therapeutic use for a number of cardiovascular disorders, including pulmonary hypertension, congestive heart failure, hypertension, and endothelial dysfunction. There are currently 3 PDE5 inhibitors available for the treatment of ED. All are effective in patients with organically based ED, including ED due to vascular disease. Sildenafil and vardenafil have relatively short half-lives of ?4 hours, whereas the half-life of tadalafil is 17.5 hours. These agents are all mild vasodilators and have minimal effects on blood pressure. Sildenafil, vardenafil, and tadalafil are all contraindicated with nitrate use. Should a patient develop chest pain while taking sildenafil or vardenafil, nitrate may be administered under supervision at 24 hours (and possibly earlier); should a patient take tadalafil and develop chest pain, nitrate may not be given until at least 48 hours after the tadalafil dose and then again, only under close monitoring. ?-Blockers are a contraindication to the use of vardenafil. Except for 0.4 mg tamsulosin, ?-blockers are a contraindication to the use of tadalafil. Sildenafil >25 mg should not be given within 4 hours of an ?-blocker. Doses of sildenafil of 25 mg may be administered at any time in relation to an ?-blocker. Vardenafil should not be administered to patients taking class IA or III antiarrhythmic drugs or to patients with congenital QT prolongation. The PDE5 inhibitors do not adversely affect total exercise time or time to ischemia during exercise stress testing. The PDE5 inhibitors are safe to administer to patients taking antihypertensive medicines (except for the ?-blockers, as described earlier). The PDE5 inhibitors are effective for the treatment of ED in patients with cardiac disease, including patients with chronic coronary artery disease 57 and hypertension. Data from controlled clinical trials do not suggest an increase in myocardial infarction or death rates in patients taking PDE5 inhibitors. These agents appear safe and effective in most patient populations but have not been studied extensively in patients with baseline severe or unstable cardiac conditions. An online-only Data Supplement is available at http://www.circulationaha.org. Dr Kloner is a compensated speaker for and consultant to Pfizer, Bayer-GSK, and Lilly ICOS, and receives research support from Lilly ICOS. If you buy something through a link on this page, we may earn a small commission. Viagra is a well-known drug for the treatment of erectile dysfunction. This is a distressing and common condition in which a man is not able to achieve or maintain a full penile erection. Research indicates that erectile dysfunction affects over 12 million men in the United States each year. Although the frequency of this problem increases with age, it is not confined to older adults. There are many alternatives to Viagra that can improve or reverse the symptoms of erectile dysfunction. These options include drugs, medical treatments, lifestyle changes, and alternative remedies. This article introduces the options available for treating erectile dysfunction. There are several alternatives to Viagra available to men with erectile dysfunction. Share on Pinterest There are many alternative oral medications to viagra. Oral drugs, including Viagra, are frequently the first course of treatment for men with erectile dysfunction. Alternative, prescription-only PDE5 inhibitors to Viagra include: Vardenafil: Sold under the brand names Levitra and Staxyn, this drug is available in tablet and disintegrating tablet form. To be effective, take vardenafil one hour before sex. Tadalafil: Available under the brand names Adcirca and Cialis, take tadalafil between 1 to 2 hours before sex. as Stendra, take avanafil tablets 15 to 30 minutes before sex. Alternatives to oral medications include: Penile self-injections: Ceratin medications, such as alprostadil, papaverine, and phentolamine, can be injected directly into the side or base of the penis. These can help achieve or maintain an erection for up to 40 minutes. Urethral suppository: Very small alprostadil suppositories can be placed in the penile urethra using a special applicator. This stimulates an erection within 10 minutes that can last for up to 60 minutes. Testosterone replacement: A doctor may suggest this treatment for men whose erectile dysfunction is linked to low levels of testosterone. The testosterone hormone can be delivered by a variety of methods, including injection, patch, or oral medication. There may be some men for whom medication is unsuitable, either because of other medical conditions or another reason. In these situations, other medical treatments may be suggested. Vacuum erection devices are hollow tubes also known as penis pumps. They are attached to a hand- or battery-operated pump and work by drawing blood into the penis. They help a man to achieve an erection that he can maintain using a tension ring. Implants are inflatable or bendable rods that are surgically implanted into the erection chambers of the penis. Doctors will usually only recommend this type of treatment as a last resort. A qualified healthcare professional must deliver these treatments. Several dietary supplements, herbal preparations, and food products are sold as remedies for erectile dysfunction. Some alternative herbal treatments, which have shown positive results in small studies, are also available. Some herbs that are generally considered to be safe and are available to purchase online include: However, be careful when purchasing or consuming any alternative products, including those that claim to be herbal versions of Viagra. Food and Drug Administration (FDA) has issued several statements warning buy viagra online forum consumers about the safety of such goods. They say these products may contain hidden synthetic chemicals or other ingredients that could be harmful. There has not been enough research to support the usage of these supplements fully. According to the FDA, lab tests show that nearly viagra tablet order online 300 of the supplements or foods marketed to enhance sexual function contain undisclosed drug ingredients. Any person using a supplement must let their doctor know. Herbs are not monitored by the FDA for quality or purity. Choose your brand/products after doing research on the company. Cialis vs Viagra - What's the difference between them? Cialis and Viagra are both PDE5 inhibitors used for the treatment of erectile dysfunction (ED). Cialis lasts for around 36 hours compared with only 4 to 5 hours for Viagra. Food does not affect the activity of Cialis, whereas food may decrease the effectiveness of Viagra. Cialis can be used once daily, at a smaller dosage, and is also effective at treating benign prostatic hyperplasia (BPH). Dosage of Cialis may need to be reduced in men with liver or kidney problems and risk of interactions may be higher than with Viagra. What ingredients are contained in Cialis or Viagra and how do they work? Cialis is the brand name for tadalafil and Viagra is the brand name for sildenafil. 1,2 Both belong to a class of medicines known as phosphodiesterase type 5 (PDE5) inhibitors. PDE5 inhibitors work only in the presence of sexual stimulation, as they rely on the natural release of nitric oxide (NO), a chemical only released during sexual arousal. NO in turn activates other substances to relax viagra for female buy online the smooth muscle inside the penis to allow the inflow of blood and an erection to occur. Which drug was first approved and which one lasts for longer? On March 27 th , 1998, Viagra became the first oral pill, and the first PDE5 inhibitor, to be approved by the FDA to treat ED. 4 A generic for Viagra was approved in March 2016 5 and released in December 2017. Cialis was first approved for ED on November 21st, 2003. 6 It was the third PDE5 inhibitor to come onto the market (after Levitra [vardenafil]). 7 Cialis has an advantage over Viagra and Levitra in that it lasts for a lot longer – 36 hours, compared with 4-5 hours for Viagra and Levitra. 1,2,7 A generic for Cialis was approved in May 2018 11 and released in September 2018. How quickly do Cialis and Viagra work and does food have any effect. Cialis generally works within 16 to 45 minutes, and its activity is not affected by food. Viagra generally works within 30 minutes, and its effect may be diminished if taken soon after a high fat meal (which may also delay how fast it works). For this reason, Viagra is best taken on an empty stomach. Effectiveness of all PDE5 inhibitors is similar; although reported effectiveness of Viagra, at 84% is slightly higher than that of Cialis at 81%. 7 However, more men prefer Cialis because of its longer duration of effect. Cialis can be taken on an as needed basis, or daily. 1 Generally, daily dosages are smaller than as needed doses. 8 Typically, Cialis is taken as a 10mg starting dose, prior to sexual activity. The dosage may be increased to 20mg if 10mg is ineffective or reduced to 5mg if side effects are intolerable. When Cialis is taken for daily use, the recommended initial dosage is 2.5mg once daily, or 5mg for people who also have BPH. Timing of the daily dosage does not matter in people using it solely for ED; however, those with BPH are advised to take it at the same time each day. Do not take more than one dose a day but your doctor may consider an increase in dosage from 2.5 to 5mg if ineffective. Side effects of Cialis include headache and indigestion. Viagra is taken on an as needed basis, at a dose of 50mg, approximately 1 hour before sexual activity (although can be taken from 30 minutes to 4 hours before). The dose may be increased to 100mg if 50mg is ineffective or decreased to 25mg if side effects are intolerable. 2 Viagra should only be taken once a day even though the effects wear off after approximately 4-5 hours. The main side effects are headache, flushing and indigestion. 2 Rarely, color perception may be altered with Viagra. Cost of Viagra varies depending on tablet strength but is approximately $24 per tablet for the 50mg strength and $35 for the 100mg strength. 9 Cialis costs approximately $8.50 for the 5mg strength and $28 for the 20mg strength, per tablet. All PDE5 inhibitors are contraindicated with nitrates. 1,2 The longer duration of action of Cialis means it is at higher risk for drug interactions, 1 and dosages may need reducing in men with kidney or liver disease. Cialis is not recommended in men who have had a heart attack or stroke within the past 6 months, with either uncontrolled high blood pressure or severely low blood pressure, unstable angina, or other conditions that make sexual activity inadvisable. Viagra, Cialis, Levitra, and Stendra are oral medications used to treat erectile dysfunction (ED). You may also know them by their generic names: sildenafil (Viagra) tadalafil (Cialis) vardenafil (Levitra) avanafil (Stendra) About 30 million American men occasionally have a problem with getting or keeping an erection, according to the Urology Care Foundation. When ED becomes a problem, many men turn to these oral ED medications. However, there are also some key differences, such as when you take them, how long they work, and what their side effects are. Viagra, Cialis, Levitra, and Stendra are all in a class of drugs called PDE5 inhibitors. These drugs work by blocking an enzyme called phosphodiesterase type 5. They also boost a chemical in your body called nitric oxide. This action encourages the muscles in your penis to relax. Relaxed muscles allow blood to flow freely so that when you’re aroused, you can get an erection. It also helps you maintain the erection long enough to have sex. Here are the basic features of each of these drugs: Brand name Viagra Cialis Levitra Stendra What’s the generic name of this drug? sildenafil tadalafil vardenafil avanafil Is a generic version available? oral tablet oral tablet oral tablet oral tablet What strengths does it come in? 25 mg, 50 mg, 100 mg 2.5 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 20 mg 50 mg, 100 mg, 200 mg What’s the typical dosage? 50 mg 10 mg (when used as needed); 2.5 mg (when used daily) 10 mg; 5 mg (for men 65 years old and up) 100 mg When do I take it? 30-60 minutes before sex 30 minutes before sex 60 minutes before sex 15 minutes before sex (for 100 mg and 200 mg); 30 minutes before sex (for 50 mg) How long does it work? 4 hours up to 36 hours 4-5 hours 6 hours How do I store it? Around room temperature, between 68°F to 77°F (20°C to 25°C) At 25°C (77°F) At 25°C (77°F) Around room temperature, between 68°F to 77°F (20°C to 25°C) The drugs are available in a variety of doses, ranging from 2.5 milligrams (mg) to 200 mg. However, taking these drugs after eating a high-fat meal does slow the rate of absorption. Most of them stay in your bloodstream for about four to five hours. Cialis is the exception, as it remains in your bloodstream for up to 36 hours. The length of time a drug stays in your system may be important if you’re taking other medications. You shouldn’t take any of these drugs more than once in a 24-hour period. Viagra, Cialis, Levitra, and Stendra are usually stocked at most pharmacies. In general, most health insurance companies won’t cover their costs. However, if you have certain medical conditions, your health plan may pay for the drug with prior authorization. The exact price you pay for viagra for female buy online any drug will depend on your insurance plan and your pharmacy. Generic versions of Viagra, Cialis, Levitra can cost half as much as their brand-name counterparts, if not less. The side effects of these medications are mostly similar.
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