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The primary efficacy endpoint was the change from baseline at Week 12 in 6MWD. The results indicate that there is no significant difference in mean change from baseline on 6MWD observed between sildenafil 20 mg plus bosentan and bosentan

alone

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Sildenafil tablets, 20 mg, are supplied as white to off-white, round shaped film-coated tablets with debossing ‘AN 351’ on one side and plain on the other side, containing sildenafil citrate, USP equivalent to the nominally indicated amount of sildenafil.

They are available as follows: Bottles of 90: NDC 68001-176-05. Recommended Storage for Sildenafil Tablets: Store at controlled room temperature 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F).

Drug Name : Sildenafil 20 MG (as sildenafil citrate) Oral Tablet Ingredient(s) : croscarmellose sodium, calcium phosphate, dibasic, anhydrous, hypromelloses, magnesium stearate, cellulose, microcrystalline, polyethylene glycols, polyvinyl alcohol, talc, titanium dioxide Imprint : AN;351 Dosage : 20 mg Color(s) : White Shape : Round Size (mm) : 7 Score : 1 NDC :68001-176.

Read this Patient Information before you start taking sildenafil citrate and each time you get a refill.

This information does not take the place of talking with your doctor about your medical condition or treatment. If teva 5343 pill cost you have any questions about sildenafil citrate, ask your doctor or pharmacist.

What is the most important information I should know about sildenafil citrate?

Never take sildenafil citrate with any nitrate medicines.

Your blood pressure could drop quickly to an unsafe level.

Nitrate medicines include: Medicines that treat chest pain (angina) Nitroglycerin in any form including tablets, patches, sprays, and ointments Isosorbide mononitrate or dinitrate Street drugs called “poppers” (amyl nitrate or nitrite) Ask your doctor or pharmacist if you are not sure if you are taking a nitrate medicine. Sildenafil citrate is a prescription medicine used in adults to treat pulmonary arterial hypertension (PAH).

With PAH, the blood pressure in your lungs is too high. Your heart has to work hard to pump blood into your lungs. Sildenafil citrate improves the ability to exercise and can slow down worsening changes in your physical condition. Sildenafil citrate is not for use in children Adding sildenafil citrate to another medication used to treat PAH, bosentan (Tracleer®), does not result in improvement in your ability to exercise. Sildenafil citrate contains the same medicine as Sildenafil citrate® (sildenafil), which is used to treat erectile dysfunction (impotence). Do not take sildenafil citrate with Sildenafil citrate or other PDE-5 inhibitors. Do not take sildenafil citrate if you: Take nitrate medicines. See “What is the most important information I should know about sildenafil citrate?” Are allergic to sildenafil or any other ingredient in sildenafil tablets.

See “What are the ingredients in sildenafil tablets?” at the end of this leaflet.

What should I tell my doctor before taking sildenafil citrate? Tell your doctor about all of your medical conditions, including if you Have heart problems such as angina (chest pain), heart failure, teva 5343 pill cost irregular heartbeats, or have had a heart attack Have a disease called pulmonary veno-occlusive disease (PVOD) Have high or low blood pressure or blood circulation problems Have an eye problem called retinitis pigmentosa Have or had loss of sight in one or both eyes Have any problem with the shape of your penis or Peyronie’s disease Have any blood cell problems such sickle cell anemia Have a stomach ulcer or any bleeding problems Are pregnant or planning to become pregnant. It is not known if sildenafil citrate could harm your unborn baby. It is not known if sildenafil citrate passes into your breast milk or if it could harm your baby. Tell your doctor about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products.

Sildenafil citrate and certain other medicines can cause side effects if you take them together. The doses of some of your medicines may need to be adjusted while you take sildenafil citrate. Especially tell your doctor if you take Nitrate medicines. See “What is the most important information I should know about sildenafil citrate?” Ritonavir (Norvir®) or other medicines used to treat HIV infection Ketoconazole (Nizoral®) Itraconazole (Sporanox) High blood pressure medicine Know the medicines you take.

Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

Take sildenafil citrate exactly as your doctor tells you. Sildenafil citrate may be prescribed to you as Sildenafil tablets Take sildenafil tablets 3 times a day about 4 to 6 hours apart.

Take sildenafil tablets at the same times every day. If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose, and take your next dose at the regular time.

Do not take more than one dose of sildenafil citrate at a time. Do not change your dose or stop taking sildenafil citrate on your own. If you take too much sildenafil citrate, call your doctor or go to the nearest hospital emergency room. What are the possible side effects of sildenafil citrate?

Low blood pressure may cause you to feel faint or dizzy. Tell your doctor if you get more short of breath after you start sildenafil citrate. More shortness of breath than usual may be due to your underlying medical condition.

Decreased eyesight or loss of sight in one or both eyes (NAION). If you notice a sudden decrease or loss of eyesight, talk to your doctor right away. If you notice a sudden decrease or loss of hearing, talk to your doctor right away.

It is not possible to determine whether these events are related directly to this class of oral medicines, including sildenafil citrate, or to other diseases or medicines, to other factors, or to a combination of factors.

Heart attack, stroke, irregular heartbeats, and death.

Most of these happened in men who already had heart problems. Tell your doctor right away if you have an erection that lasts more than 4 hours.

The most common side effects with sildenafil citrate include: Nosebleed, headache, upset stomach, getting red or hot in the face (flushing), trouble sleeping, as well as fever, erection increased, respiratory infection, nausea, vomiting, bronchitis, pharyngitis, runny nose, and pneumonia in children.

Tell your doctor if you have any side effect that bothers you or doesn’t go away. These are not all the possible side effects of sildenafil citrate.

For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects.

You may report side effects to FDA at 1-800-FDA-1088.

Store sildenafil tablets at controlled room temperature, between 68°F to 77°F (20°C to 25°C). Keep sildenafil citrate and all medicines away from children.

Medicines are sometimes prescribed for purposes that are not in the patient leaflet.

Do not use sildenafil citrate for a condition for which it was not prescribed.

Do not give sildenafil citrate to other people, even if they have the same symptoms you have. This patient leaflet summarizes the most important information about sildenafil citrate. If you would like more information about sildenafil citrate, talk with your doctor. You can ask your doctor or pharmacist for information about sildenafil citrate that is written for health professionals.

For more information go to www.amneal.com or call 1-877-835-5472. Inactive ingredients : croscarmellose sodium, dibasic calcium phosphate anhydrous, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, talc and titanium dioxide. For current full prescribing information, please visit www.amneal.com This Patient Information has been approved by the U.S.

Food and Drug Administration Manufactured by: Amneal Pharmaceuticals Co. Ahmedabad, INDIA 382220 For BluePoint Laboratories Rev. Levitra Vs Viagra:

Finding

The Best ED Treatment For You. Andy is a co-founder, the superintendent pharmacist and director at The Independent Pharmacy. Each medication helps treat erectile dysfunction (ED) issues by increasing the blood flow to the penis and are proven to help men achieve harder, longer-lasting erections for sexual activity.

The main difference between Levitra and Viagra is the active ingredient that the two medications contain.

Viagra’s active ingredient is Sildenafil, and Levitra’s is Vardenafil.

Here’s what you need to know about the difference between Sildenafil and Vardenafil: Vardenafil (Levitra) helps men: Achieve an erection within 30 minutes Provides an erection for up to 5 hours. Sildenafil (Viagra) helps men: Achieve an erection within 30-60 minutes Provides an erection for up to 4 hours.

As you can see, there is very little to choose between Levitra and Viagra in terms of effectiveness. Levitra, on average, works a little quicker and provides an erection that lasts a little longer. It’s also important to note that both only work when you are sexually aroused, meaning you need to engage in foreplay to experience the best results. To learn more about Vardenafil, read our dedicated guide for a comprehensive overview page: What is Levitra?. One of the main differences between Levitra and Viagra is the effectiveness of the two medications when ingested with food.

Food delays the absorption of all medication in the system.

If you eat a large or fatty meal before taking Viagra, the effects are likely to be significantly reduced.

Levitra, on the other hand, is typically less affected by food. The one main exception is grapefruit, which has been proven to teva 5343 pill cost significantly reduce the effect of the medication.

An alternative to both Levitra and Viagra is Cialis, which does not contain either Vardenafil or Sildenafil.

Instead, it contains a different active ingredient called Tadalafil.

By increasing blood flow to the penis, it works in a similar way to both Levitra and Viagra.

However, Cialis helps men: Achieve an erection within 30 minutes Maintain an erection for up to 36 hours. The main difference is that Cialis stays in your system for much longer than both Levitra and Viagra, therefore helping men to achieve an erection for longer. Levitra dosages and Cialis dosages available are very similar: 5mg, 5mg, 10mg, and 20mg.

Viagra, by comparison, is available in larger three doses: 25mg, 50mg, and 100mg. To see what actual users thought about Cialis as a treatment for ED read our Cialis reviews. As the name suggests, Cialis Daily is designed to be taken every day.

The medication is for men who like to have spontaneous sex more than three times a week. When taking Cialis Daily, you don’t need to take a pill 30 minutes or an hour before sex. Instead, you keep your body topped up with the medication on a permanent basis, meaning you should be able to achieve an erection whenever you want to engage in sexual activity and without the need to plan ahead. Compared to Levitra, Cialis Daily is only available in smaller packets of 2.5mg and 5mg tablets.

Below cialis cost 20mg you will find a table comparing Levitra, Viagra, and Cialis by price, dosages, how long it takes to work, and more.

Sildenafil (Viagra®) Classification: Phosphodiesterase Inhibitor. About: Sildenafil (Viagra®) Sildenafil is a medication that is taken before sexual activity and allows men with erectile dysfunction (ED) to achieve and maintain an erection. ED or impotence is a condition in which a man is unable to achieve or maintain an erection long enough for sexual intercourse. This can be a result of medical conditions such as high blood pressure, diabetes, prostate problems, and heart disease, or a side effect of the medications typically taken for these conditions. Personal lifestyle factors such as stress, alcohol and/or tobacco use can also play a contributing role. During surgery or radiation to the pelvic area (including prostate, bladder, and rectal procedures), damage can occur to the nerves that supply the penis.

This can result in either temporary or permanent impotence.

Some surgeons perform "nerve-sparing" surgeries in an attempt to preserve erectile function. Even in these cases, however, the nerves will suffer some injury, and it can take 18-24 months teva 5343 pill cost or longer for erectile function to return. These men should be treated aggressively with oral or injectable medications for ED in order to speed recovery of the nerves and to prevent muscle wasting in the penis.

It should be taken around 60 minutes

before

sex, but can be taken as much as four hours or as few as 30 minutes before sex. Your doctor will determine the dose that is best for you. Some men require dose adjustments to find the dose that works best for them.

Men who take sildenafil will not have an erection without sexual stimulation.

This drug is not an aphrodisiac and does not affect libido or desire. Having multiple intercourse sessions with one dose has not been studied. You should not adjust your dose without talking to your provider first.

Men who take nitrates, such as nitroglycerin, Nitro-Bid, Isordil, or Deponit should not take sildenafil.

Men who take Cardura, Flomax, or Hytrin for urinary symptoms should not take sildenafil. This medication can affect how other medications work.

Be sure your provider and pharmacist know all the medication (prescription and over-the-counter) and supplements you take. Store your medication in the original, labeled container at room temperature and in a dry location (unless otherwise directed by your healthcare provider or pharmacist).

This medication should not be stored in a pillbox since it should only be taken prior to sexual activity.

Ask your care team where to return any unused medication for disposal.

Do not flush down the toilet or throw in the trash.

This medication may be covered under your prescription drug plan.

Patient

assistance may be available to qualifying individuals without prescription drug coverage through the pharmaceutical company that makes the medication. Your care team can help you find these resources, if they are available.

There are a few side effects experienced with sildenafil. Talk to your doctor, nurse or pharmacist if you have concerns about these side effects. Do not take a higher dose of sildenafil than your provider orders for you. Headache, facial flushing, stuffy or runny nose, and upset stomach can occur. Less frequent side effects include blurry vision, a bluish hue to the field of vision, difficulty telling the difference between the colors blue and green, a sensitivity to light, or a sudden loss of vision or hearing. If you experience any of the following while using sildenafil, you should seek immediate medical attention: An erection lasting more than 4 hours. Chest, arm or neck pain, or nausea during sexual activity. Sudden loss of vision in one or both teva 5343 pill cost eyes, loss of hearing, ringing in the ears or dizziness. Remember, sildenafil does not protect against sexually transmitted diseases, nor does it prevent pregnancy. Effective birth control is recommended during cancer treatment.

Even if you are not producing sperm, you could still be fertile and conceive.

Cardiovascular Effects of the 3 Phosphodiesterase-5 Inhibitors Approved for the Treatment of Erectile Dysfunction.

From the Heart Institute, Good Samaritan Hospital, and the Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles.

Within the last year, 2 new phosphodiesterase-5 (PDE5) inhibitors have been approved by the US Food and Drug Administration (FDA) for the treatment of erectile dysfunction (ED). Currently, sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis) are on the market.

These agents have been shown to be effective in a broad population of men with ED, including patients with vascular disease, coronary artery disease, hypertension, and diabetes. 1–5 Because the enzyme that they inhibit, PDE-5, is found in smooth muscle cells of the systemic arteries and veins throughout the body, these agents have mild vasodilator effects and thus, have the potential to impact the cardiovascular system. 6 This fact is especially important for the patient with ED, because risk factors for ED include many of the same risk factors that are associated with coronary artery disease: lipid abnormalities, hypertension, smoking, diabetes, and lack of physical exercise. 7,8 Because erection is a vascular event, endothelial dysfunction may inhibit it.

9 Endothelial dysfunction, an early component of atherosclerosis, is rarely confined to the arteries supplying blood to the penis but more likely occurs throughout the vascular bed. Kaiser et al 10 studied 30 men with ED and observed that brachial artery flow–mediated vasodilation and nitroglycerin-mediated vasodilation were reduced in these patients compared with men without ED. Thus, ED may be an early marker of vascular disease. 10 Patients with frank coronary artery disease, known to be associated with endothelial dysfunction, and frank atherosclerosis often have ED, as we recently observed in 1 study, in which three fourths of the men with chronic stable angina also reported some degree of ED.

11 Hence, the vasodilator effect of these PDE5 agents should be taken into consideration for the cardiac patient, both as a possible concern in some cases or a possible beneficial effect in others. The purpose of the present review is to describe the cardiovascular effects of the 3 available PDE5 inhibitors, the issue of nitrate interaction, differences and similarities in labeling regarding concomitant use of nitrates and ?-blockers, their effect on the QT interval, their safety in regard to cardiac events, and the concept that these agents may eventually play a role in therapies for various cardiac conditions, including pulmonary hypertension and congestive heart failure.



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