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Bookends EasyBib EndNote (tagged) EndNote klinefelter's syndrome, congenital hypogonadotropic hypogonadism, and below don't happen very often, they could lead to serious problems if you do not seek medical attention.

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The less-catchy name might give you reason to pause, but hear us out. Like Viagra, Sildenafil has a high rate of success – whatever the underlying reasons behind your ED. In this article, we’ll try to give you the key info you need to choose between Viagra and Sildenafil.

What Are the Similarities Between Viagra and Sildenafil? Plainly speaking, Sildenafil and Viagra are the same medication and contain the same active ingredient. Sildenafil is the generic or unbranded version, and Viagra is the globally famous “little blue pill” brand. Though it may seem like Sildenafil is the newbie ED medication, there are no real solid reasons to prefer the more established Viagra product over Sildenafil. Sildenafil was invented back in the late 1980s by scientists working for American pharmaceutical company, Pfizer.

The medication was initially developed to treat heart problems like angina, but was patented by Pfizer in 1998 as Viagra

once

they’d realised its potential as a licensed ED medication. Pfizer’s patent for Viagra expired in 2012 for countries outside the US, and it expires completely in 2020.

This means that generic forms of the same medication, known simply sildenafil teva 100mg tablets as Sildenafil, can enter the market.

Both drugs have the same amount of active ingredient (Sildenafil Citrate) in each comparable dose. In medical terms, this is known as bioequivalence . Importantly for you, this means the way both drugs work, how long they take to work, how well they work and how long they work for, are the same. Despite its notoriety, Viagra is not “better” than Sildenafil or another branded product. They have the same effect on your ability to maintain an erection. Important note: The bioequivalence also means you need to steer clear of both Sildenafil and Viagra if you have been medically advised against taking either of them. Sildenafil and Viagra both work by inhibiting the PDE5 enzyme, which controls muscle contraction in the penis. The drug allows the blood vessels in the penis to relax and expand,

boosting

the blood sildenafil teva 100mg tablets flow to the area and making it easier to maintain a lasting erection.

It is beneficial to be sexually aroused for both medications to work effectively, so you’ll need to get in the mood, relax, and let the pill do its thing! MHRA approved and clinically proven to be highly effective by increasing blood flow into the penis. Viagra, Cialis, Levitra, and Stendra are oral medications used to treat erectile dysfunction (ED).

You may also know them by their generic names: sildenafil (Viagra) tadalafil (Cialis) vardenafil (Levitra) avanafil (Stendra) About 30 million American men occasionally have a problem with getting or keeping an erection, according to the Urology Care Foundation.

When ED becomes a problem, many men turn to these oral ED medications.

However, there are also some key differences, such as when you take them, how long they work, and what their side effects are.

Viagra, Cialis, Levitra, and Stendra are all in a class of drugs called PDE5 inhibitors.

These drugs work by blocking an enzyme called phosphodiesterase type 5.

They also boost a chemical in your body called nitric oxide. This action encourages the muscles in your penis to relax.

Relaxed muscles allow blood to flow freely so that when you’re aroused, you can get an erection.

It also helps you maintain the erection long enough to have sex. Here are the basic features of each of these drugs: Brand name Viagra Cialis Levitra Stendra What’s the generic name of this drug? sildenafil tadalafil vardenafil avanafil Is a generic version available?

oral tablet oral tablet oral tablet oral tablet What strengths does it come in? 25 mg, 50 mg, 100 mg 2.5 mg, 5 mg, 10 mg, 20 mg 5 mg, 10 mg, 20 mg 50 mg, 100 mg, 200 mg What’s the typical dosage?

50 mg 10 mg (when used as needed); 2.5 mg (when used daily) 10 mg; 5 mg (for men 65 years old and up) 100 mg When do I take it? 30-60 minutes before sex 30 minutes before sex 60 minutes before sex 15 minutes before sex (for 100 mg and 200 mg); 30 minutes before sex (for 50 mg) How long does it work? 4 hours up to 36 hours 4-5 hours 6 hours How do I store it? Around room temperature, between 68°F to 77°F (20°C to 25°C) At 25°C (77°F) At 25°C (77°F) Around room temperature, between 68°F to 77°F (20°C to 25°C) The drugs are available in a variety of doses, ranging from 2.5 milligrams (mg) to 200 mg. However, taking these drugs after eating a high-fat meal does slow the rate of absorption.

Most of them stay in your bloodstream for about four to five hours. Cialis is sildenafil teva 100mg tablets the exception, as it remains in your bloodstream for up to 36 hours. The length of time a drug stays in your system may be important if you’re taking other medications.

You shouldn’t take any of these drugs more than once in a 24-hour period.

Viagra, Cialis, Levitra, and Stendra are usually stocked at most pharmacies.

In general, most health insurance companies won’t cover their costs. However, if you have certain medical conditions, your health plan may pay for the drug with prior authorization.

The exact price you pay for any drug will depend on your insurance plan and your pharmacy.

Generic versions of Viagra, Cialis, Levitra can cost half as much as their brand-name counterparts, if not less.

The side effects of these medications are mostly similar. Below are the drugs’ most common side effects, according to their manufacturers: Side effect Viagra Cialis Levitra Stendra Stuffy or runny nose x x x x Headache x x x x Dizziness x x Upset stomach x x x Nausea x Indigestion x x Vision changes x Rash x Flushing x x x x Back pain x x x x Pain in the limbs x Muscle aches x x Sore throat x. Tell your doctor if you have any side effects that linger and don’t go away on their own. If you have an erection that lasts longer than four hours, call your doctor right away.

This condition, known as priapism, is a risk associated with all of these ED drugs. Unlike Viagra and the other PDE5 inhibitors, Cialis is also approved to treat enlarged prostate.

Both Viagra and Cialis can be taken 30 minutes before sexual activity.

However, Cialis lasts much longer and is noteworthy for the amount of time it remains in your body.

You may feel the effects of the drug up to 36 hours after you take it.

The fact that it comes in a low-dose (2.5 mg) version also means that Cialis can be taken every day. A daily dose will ensure that the drug’s always in your system. This side effect isn’t associated with any other oral ED drugs. Viagra can take 30 to 60 minutes to work in the body, while Levitra takes 60 minutes.

Levitra does have fewer common side effects than Viagra, and it isn’t associated with a rash or muscle aches.

While vision changes are considered a common side effect of Viagra, changes to color perception are only a rare side effect of Levitra. Stendra is the newest drug on the market, and no generic version is available for sale yet.

The 100-mg and 200-mg doses can be taken as shortly as 15 minutes before sexual activity. As a second-generation medication, Stendra also seems to have milder side effects than Viagra and the other PDE5 inhibitors that came before it.

Side effects commonly caused by Viagra — but not Stendra — include dizziness, vision changes, nausea, and muscle aches. The only common side effect caused by Stendra but not Viagra is a sore throat.

Each drug comes with the risk of drug interactions.

Since PDE5 inhibitors work on the body in similar ways, Viagra, Cialis, Levitra, and Stendra lead to similar interactions.

All four of these drugs interact with: nitrates, such as isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) certain blood pressure drugs, such as calcium channel blockers alpha blockers, which can treat high blood pressure or an enlarged prostate certain pulmonary hypertension drugs, such as riociguat (Adempas) protease inhibitors, a class of HIV drugs antifungal drugs, such as ketoconazole and itraconazole (Onmel, Sporanox) antibacterial drugs, such as clarithromycin (Biaxin) Drinking excessive amounts of alcohol while on any PDE5 inhibitor should be avoided, and you shouldn’t combine different ED drugs.

Cialis may also be less effective if used alongside antiseizure medications such as carbamazepine (Tegretol) and phenobarbital. For specifics on which medications are safe for you to use, it’s best to consult your doctor or pharmacist.

In some cases, using these medications may mean you need to completely avoid PDE5 inhibitors. In other cases, adjusting your dosage of the medication can reduce the possibility of drug interactions while using PDE5 inhibitors. If you have ED, talk to your doctor about Viagra, Cialis, Levitra, and Stendra. Tell your doctor if you take other over-the-counter or prescription drugs or supplements. Be sure to mention all other health conditions you have. When used correctly, each of these

drugs

has been shown to help men with ED. If you have questions or concerns, talk with your doctor. All of them lead to good results, but it may take a little time and patience to get it right.

If one drug doesn’t work or produces unpleasant side effects, you can try another drug. It may also take some trial and error to find the dosage that works best for you.

If you’re not sure that drug treatment is right for you, you can also give natural ED treatments a try. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China. Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China. Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China. Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, 330000 Jiangxi Province China.

Erectile dysfunction (ED) is a major care problem worldwide.

Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED. This systematic review and meta-analysis were conducted to directly compare tadalafil with sildenafil for the treatment of ED.

We designed a strategy for searching the PubMed, Embase, EBSCO, Web of Science and Cochrane library databases; the reference lists of the retrieved studies were also investigated.

A literature review was performed to identify all published randomized or non-randomized controlled trials that compared tadalafil with sildenafil for the treatment of ED and to assess the quality of the studies.

Two investigators independently and blindly screened the studies for inclusion. A total of 16 trials that compared tadalafil with sildenafil for the treatment of ED were included in the meta-analysis.

In the meta-analysis, tadalafil and sildenafil appeared to have similar efficacies and overall adverse event rates.

However, compared with sildenafil, tadalafil significantly improved psychological outcomes. Furthermore, the patients and their partners preferred tadalafil over sildenafil, and no significant difference was found in the adherence and persistence rates between tadalafil and sildenafil.

Additionally, the myalgia and back pain rates were higher and the flushing rate was lower with tadalafil than with sildenafil. Tadalafil shares a similar efficacy and safety with sildenafil and significantly improves patients’ sexual confidence.

Furthermore, patients and their partners prefer tadalafil to sildenafil.

Hence, tadalafil may be a better choice for ED treatment. Erectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient to permit satisfactory sexual intercourse. ED is one of the most common sexual dysfunctions, and an estimated 5–20% of men are affected by moderate to severe ED around the world [1].

The prevalence of ED is approximately 15.77% in southern India, 15.0–49.5% in China, 56.1% in Iran and 58.9% in south-western Nigeria [2–5].

The estimated global prevalence has been increasing, and approximately 322 million men worldwide could be affected by ED by the year 2025 [6]. Although ED is a benign disorder, it can affect physical and psychosocial health and may have a significant impact on the quality of life of patients and their partners. Currently, several treatment strategies are available for patients with ED, including non-invasive and invasive options.

Oral phosphodiesterase type 5 inhibitors (PDE5-Is) are the first-line therapy for ED [7].

PDE5-Is are similar to cyclic guanosine monophosphate (cGMP) in structure; thus, PED5-Is can bind to PDE5 competitively and inhibit cGMP hydrolysis, leading to a penile erection [8].

Four PDE5-Is (sildenafil, tadalafil, vardenafil and avanafil) are currently approved by the US FDA and have comparable efficacy and side effect profiles [9]. Sildenafil and tadalafil are the two most common phosphodiesterase inhibitors (PDEIs) around the world.

Sildenafil, the original PDEI, was introduced in 1998. Sildenafil has a quick onset of action of 30 min after the initial dose, a duration of action of 4–6 h and a maximum duration of 12 h [10].

Sildenafil is effective for the treatment of ED, although 20–50% of patients who respond to sildenafil discontinue its use [11].

Tadalafil is a selective, long-acting PDEI that was released in 2003.

Tadalafil has an onset of 20 min and should be taken 30 min prior to intercourse; additionally, this drug has the longest duration of action in its class and a maximum duration of 72 h. A total of 52% of patients can have successful intercourse within 30 min of taking tadalafil [12]. Recently, several systematic reviews and meta-analyses have comparatively analysed the role of PDEIs, including sildenafil and tadalafil, in the treatment of ED. However, because most of these review articles were indirect comparative analyses, the differences between sildenafil and tadalafil remain unclear [13–15]. Hence, this meta-analysis was conducted to directly compare sildenafil with tadalafil for the treatment of ED and to provide guidance for the clinical treatment of ED.



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