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This author on Google Scholar Find has been damaged from a radical prostatectomy or in men with diabetes mellitus drug; CON, control; LEV, levetiracetam; LTG, lamotrigine; OXC, oxcarbazepine.

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Some complementary therapies, such as acupuncture, have claimed to treat erectile dysfunction. There are lots of treatments that claim to be a "herbal Viagra".

A herbal Viagra has never been approved as a treatment for erectile dysfunction.

Women can use sildenafil for pulmonary hypertension. There's no good evidence that sildenafil works for women with sexual problems. There's no firm evidence to suggest that taking sildenafil will reduce fertility in either women or men.

But speak to a pharmacist or your doctor before taking it if you're trying to get pregnant. Sildenafil does not affect any type of contraception, including the contraceptive pill and emergency contraception. A beer or a couple of glasses of wine are not likely to stop or delay sildenafil working.

But drinking lots of alcohol can make it more difficult to get an erection.

To get the most benefit from sildenafil, do not drink heavily before taking it.

Taking poppers (amyl nitrite) with sildenafil can have a dangerous effect on your heart. It can also be potentially dangerous to take sildenafil with: stimulants like MDMA (ecstasy) or cocaine hallucinogens like LSD

novel

psychoactive substances (which used to be known as legal highs) like mephedrone.

Sildenafil has not been properly tested with recreational drugs.

Talk to your doctor if you think you might use any recreational drugs with sildenafil.

Do not drink grapefruit juice if you're taking

sildenafil

(Revatio) for pulmonary hypertension. You can eat and drink normally while taking sildenafil (Viagra) to get an erection. Erectile dysfunction can often be improved if you make changes to your lifestyle, such as: Related conditions.

Ejaculation problems Erectile dysfunction (impotence) Male sexual problems Priapism (painful erections) Pulmonary hypertension.

Relate (sex therapy): charity Sexual Advice Association: charity Sildenafil: forum Viagra: forum.

Page last reviewed: 22 January 2019 Next review due: 22 January 2022.

Posted on 16 May 2016 24 October 2019 by Dr Tony Steele - Dr Fox is a CQC , GPhC , & MHRA regulated service. Both Viagra and sildenafil are widely used to treat erectile dysfunction.

Viagra is a brand name for the sildenafil produced and sold by the company Pfizer.

Sildenafil is also sold as a generic drug, which is medically identical to Viagra.

Sildenafil citrate was created in 1989 by British scientists Albert Wood and Peter Dunn as a possible treatment for hypertension and angina; conditions associated with coronary heart disease.

Nicholas Terrett, now often referred to as the father of Viagra, was named in the British patent for the drug as a heart medication. And though Pfizer’s early trials of the drug in the 1990s did not prove its efficacy as a heart medication, patients who took part in the clinical trials

reported

increased erections after taking sildenafil. Separate studies provided more information on the biochemical process that causes erections, which helped scientists understand how sildenafil could enhance the effects of sexual stimulation and open up blood vessels in the sildenafil the generics pharmacy penis.

Sildenafil was then studied in men with erectile dysfunction, and in 1998 it was approved by the FDA specifically for treatment of ED.

When Pfizer lost its UK patent for the drug in June

2013

it made way for generic manufacturers to produce sildenafil, or ‘generic Viagra’. It costs a fraction of the price of Viagra, and has made the treatment more accessible to a wider range of patients. You can now choose to buy Viagra, Pfizer’s branded drug, or sildenafil, the generic version. Branded Viagra comes in small diamond-shaped blue pills – Pfizer has also patented this pill design and appearance.

Sildenafil is sold as white or blue tablets, with different characteristics depending on the brand. Some sildenafil overnight delivery have chalky finishes while others are smooth, and some are scored for easy division, while others are not. Both Viagra and the different brands of sildenafil can be purchased in 25mg, 50mg, and 100mg preparations, and there is no significant difference between them in terms of active ingredients. Sildenafil tablets can come in many shapes, colours, and sizes – see comparing brands of sildenafil.

As a generic medicine, sildenafil is produced by a number of manufacturers, and competition among them helps to regulate its price and keep it affordable for consumers.

Branded Viagra is only produced by Pfizer, whose name recognition and customer loyalty allow it to charge a higher price for its renowned ‘little blue pills’.

It is a requirement for the generic version to contain the same levels of the active ingredient in the body as its branded alternative, which is known as bioequivalence. Before generic drugs are licensed for sale the manufacturer must demonstrate bioequivalence to the licensing authorities (the European Medicines Agency). If you have a private prescription for Viagra, the branded drug must be dispensed; but you may ask for sildenafil at the time that the prescription is made. They are considered equally effective, however patients must follow proper protocol for optimum results.

Also note that if the condition does not respond to the initial dose of Viagra or generic sildenafil, a higher dose may be required (after several unsuccessful attempts). Packaging differences: Viagra 100mg tablets and Mylan sildenafil 100mg tablets.

Although Viagra is the most well-known medication for erectile dysfunction, a number of alternative treatments have become available in recent years. Though many people would like to know which treatment is better, there really is no straightforward answer to that question.

Both treatments can help men achieve satisfying erections and beat their erectile dysfunction, but both also have differing characteristics which will suit different men in different ways. You should bear in mind that the effectiveness of the treatment varies from one man to another, depending on the cause of the erectile dysfunction, its severity and the amount of sexual stimulation the patient receives.

Therefore until you try for yourself, you cannot be sure of the exact results you will achieve. They relax the smooth muscles in the blood vessels supplying the penis. This relaxation increases blood flow to aid an erection.

However Viagra and Cialis have different active ingredients.

In Viagra the PDE-5 inhibitor is sildenafil, while in Cialis it is tadalafil .

Some men may react better to one active ingredient than the other.

However both sildenafil and tadalafil work via the same mechanism so you should never take the two drugs together. Nor should you take more than one Viagra or Cialis pill at any one time.

Both drugs require a sexual stimulus in order to take effect. Neither Viagra or Cialis will cause an erection on their own. Viagra was initially developed and tested in the UK to treat angina and was meant to relax the blood vessels that supply the heart.

While the results for treating angina were disappointing, many participants reported developing erections after taking Viagra.

Further research showed that

Viagra

relaxed the blood vessels supplying the erectile tissues.

The medication was launched in 1998 by Pfizer, and approved by the European Medicines Agency and US Food and Drug Administration, as the first oral drug to treat erectile dysfunction.

Following the launch of Viagra, Eli Lilly joined forces with the ICOS Corporation to develop a newer version of this erectile dysfunction treatment.

This treatment, Taladalafil, was approved for sale in 2002 in Europe, then in the US the following year.

You can take Cialis as little as 30 minutes before you plan to have sex; whereas Viagra must be taken at least one hour before sex.

If you have a large meal shortly before taking a pill, it will slow down the rate at which Viagra takes effect. In contrast, you can take Cialis before or after eating. With both treatments you should limit your alcohol intake to enjoy the greatest effects. It is not unusual for a man not to respond to erectile dysfunction treatment the first time he takes it. Indeed it is recommended you try taking the tablet on up to eight occasions.

Then if no results are forthcoming sildenafil overnight delivery discuss with your doctor about switching to a different dose or form of treatment.

The biggest difference between Viagra and Cialis is the amount of time their effects last.

Viagra remains effective for 4 to 6 hours, which offers ample opportunity to have sildenafil overnight delivery sex on multiple occasions if you wish. However Cialis typically allows you to achieve erections for up to 36 hours after taking a tablet. Although Cialis lasts for up to 36 hours, this does not mean you will have an erection throughout that time – it should only happen when you are sexually stimulated. Cialis has comfortably the longest effectiveness period of any erectile dysfunction drug on the market.

Side effects for either drug are rare but not unheard of.

As Cialis and Viagra are both PDE-5 inhibitors, they have similar side effects; although you may find that because Cialis is effective for longer, any side effects you experience may also last for longer. The most likely unwanted effects are light-headedness, headaches or flushing to the face. Nasal congestion, indigestion and visual changes are sometimes experienced as well. If you experience chest pain or a prolonged erection for more than four hours, you must seek urgent medical help.

Both Viagra and Cialis are prescription drugs so you must consult with a doctor before you sildenafil overnight delivery can take them.

Cost is another notable distinction between Viagra and Cialis.

The longer effectiveness of Cialis is reflected in its price.

While Cialis is slightly more expensive than Viagra, many men will consider the vastly greater duration period of Cialis to represent good value for money.

Equally, plenty of men will prefer the cheaper price and renowned brand name offered by Viagra.

But ultimately it depends entirely on the individual. Sildenafil and Tadalafil are the most well-known of all the ED medications.

They are both in a class of medications called ‘phosphodiesterase type 5 (PDE5) inhibitors’ and work in a very similar way.

These medicines work in the presence of sexual stimulation.

Once aroused, a natural chemical is released, which the PDE5 inhibitors rely on to work with. Once this natural chemical is released, a chain reaction begins, relaxing the smooth muscle inside the penis.

There is then an increase in blood flow into the penis allowing the penis to can become erect. What’s the difference between Sildenafil and Tadalafil? Sildenafil has been around since 1998, which means a lot is known about the positive effects and also the side effects. It works within an hour of taking the medication and for its full effect, should be taken on an empty stomach. The effects of Sildenafil generally last for four to five hours.

Viagra was developed by the pharmaceutical company Pfizer and they were the only company that could legally manufacture it until 2013. In 2013, their patent expired which meant that other companies could produce their own erectile dysfunction medications containing the active ingredient sildenafil. When you see the medication ‘Sildenafil’, you can be assured that it contains exactly the same active ingredient as Viagra.

However, as it is a generic version rather than the brand, it is considerably cheaper. The more common side

effects

of Sildenafil can include headache, nausea, stuffy nose, flushing and indigestion.

There are also some rarer side effects; you should always read the accompanying leaflet that comes with any medicine before taking it.

Sildenafil is taken on an as needed basis, usually at a dose of 50mg. These may be increased to 100mg if the standard dose is ineffective, or lowered to 25mg if mild side-effects are experienced. The dosing may be different depending on your medical history, so your doctor should discuss an appropriate starting dose with you. In 2003, a company named Eli Lilly introduced Cialis as an alternative ED medication.

The company had the patent on Tadalafil until November 2017.

Similarly to Viagra, now that the patent has expired, other companies are permitted to make their own version of Tadalafil, the active ingredient in Cialis.

Again, as it is a generic version of the brand, Cialis, the medication is considerably cheaper.

Tadalafil has two formulations – one that can be taken 'as required', and one that can be taken daily. The 'as required' Tadalafil (generic Cialis) has an advantage over Sildenafil in that it lasts a lot longer – up to 36 hours (compared with 4-5 hours for Sildenafil). Some men prefer this as it allows for more spontaneity.

Tadalafil also works faster than Sildenafil – it generally works within 30 minutes, though for some men it can take up to an hour. The action of Tadalafil is not affected by food, and this is another reason why some men may prefer it.

The standard 'as required' Tadalafil dose is 10mg, which may be increased to a maximum of 20mg if the medication is ineffective.

This dose also depends on your medical history, so your doctor will discuss

the

appropriate starting dose with you.

The daily version of Tadalafil known by its brand name Cialis Daily, is recommended for those who have sex more than twice a week.



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