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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

Fast acting, effective distinct types of brain dysfunction the researchers found and afford a doctor and relied on an unqualified “grandmother” who lived up the street who had convinced everyone (including herself) that she was.

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(Primene, Prosol, Clinimix, Olimel, Travasol, Smofkabiven, Aminosyn) Increased mortality in pre-term infants (premature babies who are born before 37 completed weeks of gestation) when solution is not shielded (protected) from light. Renal (kidney) injury, including acute renal failure.

(Januvia, Janumet, Onglyza, Komboglyze, Trajenta, Jentadueto, Nesina, Kazano, Oseni) Sitagliptin, saxagliptin, linagliptin, alogliptin, (metformin combination) Serious arthralgia (joint pain) Gadolinium containing products.

(Magnevist, Gadovist, Omniscan, Multihance, Optimark, Prohance, Primovist) Gadoversetamide, gadobutrol, gadopentetate, gadobenate, dadodiamide, gadoteridol, gadoxetate. Build-up of the Gadolinium containing products in the brain. Hematological disorders (disorders mainly affecting the blood) in neonates (newborns) Gastrointestinal perforation (hole that develops through the wall of the stomach,

small

intestine, large intestine, gallbladder or rectum. No safety reviews were started between 2015-11-01 and 2015-11-30. Safety reviews started between 2015-10-01 and 2015-10-31 Brand Name or Product Class / Medical Device(s) Medicinal Ingredient(s) Potential Safety Issue Forxiga, Invokana, Jardiance (SGLT2 class inhibitors) Dapagliiflozin, canagliflozin, empagliflozin Increased risk of bone fractures, due to loss of bone mineral density Avonex, Betaseron, Extavia, Plegridy, Rebif (Beta-interferons) Interferon beta Risk of pulmonary arterial hypertension (type of high blood pressure

that

affects

the arteries in the lungs and the right side of the heart).

Safety reviews started between 2015-07-01 and 2015-09-30 Brand Name or Product Class / Medical Device(s) Medicinal Ingredient(s) Potential Safety Issue.

Atypical Antipsychotic: Abilify, Clozaril, Invega, Latuda, Risperdal, Seroquel, Zeldox, Zyprexa.

Aripiprazole, clozapine, paliperidone, lurasidone, risperidone, quetiapine, ziprasidone, olanzapine.

Urinary amoxicillin good for sinus infection retention (temporary difficulty urinating and incomplete bladder emptying) Neisseria meningitidis group B.

Safety

of vaccination with Bexsero in older patients.

Digoxin, Apo-Digoxin, Lanoxin, PMD-digoxin, Toloxin. Increased mortality (death) Dimetane Expectorant DC, Tussionex, PMS-hydrocodone, Novahistine, Dalmacol, Hycodan, Novahistex DH, Ratio-calmydone, Tramacet, Zytram, Tridural, Ralivia, Ultram, Durela, and generic formulations of tramadol.

Life-threatening respiratory depression (very slow breathing requiring emergency care) in children.

Ovarian cancer in menopausal women (a type of cancer detected in the ovaries) Rivastigmine hydrogen tartrate.

Increased mortality (death) Progressive multifocal leukoencephalopathy (a serious brain infection) Malignancies (tumors which are cancerous and can cause serious illness or death), neoplasms (new and abnormal growth of tissues) Hepatitis A inactivated.

Immune

thrombocytopenic

purpura (ITP) (a disorder that can lead to easy or excessive bruising and bleeding) Raynaud's phenomenon (disorder that causes some areas of the body to feel numb and cold as a result of a limited blood circulation) Drug-drug

interaction

with methotextrate.

Use of Soliris in patients that are receiving meningococcal B vaccine at the same time. Capillary leak syndrome (disorder that can lead to a leak of fluid from the blood vessels into the body's tissues) Amoxicillin for clinically unsuspected pneumonia in primary care: subgroup analysis.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: b.d.l.broekhuizen@umcutrecht.nl.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site.

Find this author on Google Scholar Find this author on PubMed Search for this author on this site.

Antibiotic treatment is recommended

for

pneumonia [1, 2].

However, some studies have suggested that the milder spectrum of pneumonia in primary care does not have important adverse consequences if missed and, therefore, managed without antibiotics [3–5]. Better insight in the effects of antibiotics for pneumonia in primary care could improve patient information and management. Antibiotic treatment is recommended for pneumonia [1, 2].

However, some studies have suggested that the milder spectrum of pneumonia in primary care does not have important adverse consequences if missed and, therefore, managed without antibiotics [3–5]. Better insight in the effects of antibiotics for pneumonia in primary care could improve patient information and management. The aim of our study was to assess whether antibiotic treatment influenced outcome in patients presenting with acute lower respiratory tract infection (LRTI) with a radiologically proven, but clinically unsuspected, pneumonia compared to those without pneumonia.

This was a secondary analysis of a randomized, placebo controlled trial of amoxicillin for acute LRTI in 16 primary research networks in 12 European countries from October 2007 until April 2010.

More details on this GRACE-10 study (Genomics to combat Resistance against Antibiotics in Community-acquired LRTI in Europe, www.gracelrti.org) have been reported elsewhere [6].

Eligible patients were aged ?18 years who consulted their general practitioner (GP) for the first time with an acute cough (duration of ?28 days) as the main symptom. Exclusion criteria

were

clinically suspected pneumonia [7], based on focal chest signs (focal crepitations and bronchial breathing) and systemic features (high fever, vomiting and severe diarrhoea); pregnancy, allergy to penicillin, treatment with antibiotics in the previous month and immunodeficiency. The study was approved by ethics committees in all participating countries and all participants provided written informed consent.



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