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Analogue of ampicillin, is a semisynthetic antibiotic with essentially the all patients who present agar (Biokar®) were prepared and sterilized according to the manufacturers’ instructions. Another drug and may not reflect the rates.

Precludes determination of optimal treatment time for the drugs decade before someone else turned penicillin into the miracle drug chew the chewable.

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The sample size was calculated with a 95% confidence level and statistical power of 80%. A SD of 1.0 mm with an expected difference of 1.0 mm probing depth reduction between treatments.

This resulted in a total of 14 patients per arm; however, considering an attrition of about 20%, it was established that least 21 subjects should be included in each treatment group.

Download figure Open in new tab Download powerpoint. Download figure Open in new tab Download powerpoint.

Download figure Open in new tab Download powerpoint.

Comparison between groups in final clinical assessments. Basal demographics characteristics and clinical parameters of study groups.

No loss of teeth between groups compared with baseline was reported. No serious adverse events occurred during the study. Complications due to diabetes have negative effects on different aspects of patients’ health: economics, quality of life, and self-esteem. Periodontitis is a common complication in patients with diabetes, not frequently mentioned.

Poor glycemic control associated with periodontitis can modify the connective tissues response and the progressive destruction of periodontal structures. Periodontal treatment may have a positive effect on hyperglycemia, independently of diabetic treatment.17–19.

Recent evidence has shown that the use of adjunct systemic antibiotics with SRP in amoxicillin 500 uses patients with diabetes is inconclusive.10–12 Santos et al , in a systematic review, evaluated the effect of different antibiotics on periodontal parameters in patients with diabetes. The results showed a positive significant effect with the use of SRP plus antibiotics, reducing the probing depth and bleeding in probing.20 Our results showed a similar reduction in both parameters with the use of clindamycin or amoxicillin-metronidazole.

In addition, these findings are in concordance to other randomized clinical trials that had used systemic antibiotics in similar populations.21–25.

Several authors refer to SRP plus amoxicillin-metronidazole as the most effective therapy for periodontitis in patients with diabetes when compared with several antibiotics.26–29 However, no studies compare AMX-MET with clindamycin. Clindamycin is a broad-spectrum antibiotic, active against aerobic and anaerobic bacteria including coverage against beta-lactamase producing pathogens.

It could be considered an option in the treatment of diabetic infections in different sites.30. Unlike other studies, the present trial shows that clinical benefit can be achieved with 7 days of antibiotic treatment vs the 14 days prescribed by other authors.31 According to a rational use of antibiotics, the duration of treatment should be the shortest possible and

most

acute oral infections are resolved in less than 7 days.32 Moreover, the use of short courses have some advantages: fewer adverse events, more adhesion, lower costs, and so on.32 There is a tendency to use higher doses for a shorter time, but the evidence about this practice is not conclusive.33 We consider a better option is to use standard doses for a shorter time as complement to periodontitis treatment. The intragroup significant differences between baseline and the final visit were observed in both groups.

The efficacy of amoxicillin and metronidazole in the treatment of periodontitis is established evidence.

However, the use of clindamycin is a new option in oral infections.

In addition, in the present study, no teeth were reported to have been lost in either group.

The principal limitation of the present study was the absence of a group with SRP plus placebo. This study design, using a placebo group, could help us to evaluate the efficacy of clindamycin versus SRP alone.

However, this study shows that clindamycin is a new option similar to AMX-MET for periodontitis treatment in patients with diabetes.

The administration during 7 days of clindamycin or amoxicillin/metronidazole showed the same efficacy for reducing probing depth, plaque index, and bleeding on probing in patients with periodontitis and type 2 diabetes.

We appreciate the comments and correction style of Paul Riordan of Write 2 Publish.

We also appreciate the comments and support of Raul Baptista Rosas amoxicillin for chest infection and Luis Cortes of Research Department of CUTonala. Comparison of adjunctive azithromycin and amoxicillin/metronidazole for patients with chronic periodontitis: preliminary randomized control trial.

Oral Health Centre of Western Australia, Nedlands, Western Australia, Australia.

Associate Professor and Head of Periodontology Department.

Oral Health Centre of Western Australia, Australia.

Princess Margaret Hospital, Subiaco, Western Australia, Australia. Centre for Applied Statistics, School of Mathematics and Statistics, The University of Western Australia, Western Australia, Australia. Oral Health Centre of Western Australia, Nedlands, Western Australia, Australia. Associate Professor and Head of Periodontology Department.

Oral Health Centre of Western Australia, Australia. Princess Margaret Hospital, Subiaco, Western Australia, Australia. Centre for Applied Statistics, School of Mathematics and Statistics, The University of Western Australia, Western Australia, Australia. There are insufficient guidelines for the use of adjunctive systemic antibiotics for patients with periodontal disease.

The aim of this study was to compare clinical outcomes for patients with moderate?advanced chronic periodontitis treated with: scaling and root planing (SRP), SRP with amoxicillin and metronidazole (A+M), SRP with Azithromycin (Az).

Thirty?seven non?smokers with generalized moderate to advanced chronic periodontitis were divided into three treatment groups: SRP, A+M and Az. Patients received the medications after the last SRP session and were reviewed three months later.

Changes in clinical parameters were compared between the groups.

Separate

analyses were executed for: ‘all sites’, ‘molar sites’, ‘sites with different PPD severities’ and ‘number of sites with shallow, moderate and deep PPD’.



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